Biomedical subjects

G Zapponi

Publications and source records attributed to G Zapponi.

12 recordsLinked to original sources

PubMed1988

Exposure to agricultural treatment residues: some simple statistical considerations based on monitoring data for ethoxyquin on apples.

The data examined here concern ethoxyquin levels, mainly measured in apple samples from the retail market. In this study about three hundred measurements, carried out on apples in Northern-Central Italy and recently published, are examined, with the purpose of defining the main characteristics of value statistical distribution and variability and to optimize sampling criteria. The analysis did not indicate the presence of significantly high levels or consequently significantly high risks; nevertheless, it pointed out some important aspects in data collection and evaluation. First, it appeared that the statistical distribution of data is typically nonsymmetrical, non-Gaussian, and characterized by a tail extending toward the high values. The logarithmic transformation of data appeared useful in order to obtain a Gaussian distribution. As a rule, the data variability appeared to be high. The frequency and distribution of values above the analytical threshold resulted in significant change, both in time and in space. The percentage of positive values (above the analytical threshold) appeared to vary up to a factor of 2-3, as analogously did their geometric mean.(ABSTRACT TRUNCATED AT 250 WORDS)

Environmental Monitoring↗

PubMed1986

The chemical risk management process in Italy. A case study: the Seveso accident.

This paper describes, by means of a unique case study, i.e. the ICMESA accident at Seveso, the process of chemical risk management in Italy under emergency conditions which involved more than 200,000 people and about 1800 ha of a densely populated area. The paper also deals with the aims, the results, and the organizational aspects of the medium- and long-term activities that were carried out to rehabilitate the affected ecological and social systems. Problems of co-ordination at different levels (national, regional, provincial and local), as well as of interaction of decision-makers with scientific and technical experts and local staff responsible for action, have also been addressed.

Accidents↗

PubMed1982

In vitro proliferation of lymphocytes from celiac children and their first-degree relatives in response to wheat gliadin-derived peptides.

Evidence is accumulating which indicates that immune reactions to gliadins are involved in the pathogenesis of celiac disease, as humoral- and cell-mediated immune responses to gliadins have been demonstrated in the jejunal mucosa and the peripheral blood of patients. An abnormal specific immunological response to gliadins is demonstrated not only in celiac children but also in their first-degree relatives. Seventy-eight percent of celiac patients, and 67, 87, and 100% of their fathers, siblings, and mothers, respectively, have a peripheral blood lymphocyte population reacting in vitro with a proliferation response to at least one of four peptide mixtures obtained from bread and durum wheat gliadins using a procedure simulating in vivo protein digestion. The specificity of this immunological hyperresponsiveness against wheat gliadins is shown by two sets of data: (a) Lymphocytes from celiac children and their relatives were much less sensitive to peptides from rice prolamin and not at all sensitive to peptides from wheat albumins. (b) Only 7% of 30 adult controls had a proliferative response of their peripheral lymphocytes to wheat gliadin peptides. It is not known at this time if healthy relatives of celiac patients mount an immune response against the intestine in vivo. However, it is possible that the presence of lymphocytes reactive to wheat gliadin peptides in apparently healthy relatives of celiac patients may explain why these relatives develop histologic evidence of celiac disease when their gluten intake is increased (Doherty M, Barry RF. Lancet 1981;1:517-20).

Albumins↗

PubMed1980