Biomedical subjects

G Zardini

Publications and source records attributed to G Zardini.

4 recordsLinked to original sources

PubMed1998

Long-term selective IgG immuno-adsorption improves Rasmussen's encephalitis.

We report that long-term selective immunoglobulin G immunoadsorption by protein A (PAI) improved seizure frequency and neuropsychological deficits in a 16-year-old patient with severe treatment-resistant Rasmussen's encephalitis (RE). Clinical improvement correlated with reduction of antiglutamate receptor 3 antibodies. The efficacy of PAI in our patient supports the autoimmune hypothesis of RE and suggests its application to avoid, or at least delay, functional hemispherectomy in selected cases.

Adolescent↗

PubMed1995

Linguistic development in a patient with Landau-Kleffner syndrome: a nine-year follow-up.

A longitudinal linguistic analysis of aphasic disorder in a 15-year-old boy affected by Landau-Kleffner syndrome followed since the age of 6 is reported. The phonological, morphosyntactic and lexical levels of verbal deficits have been evaluated by means of collected samples of spontaneous language and a battery of linguistic tests. The clinical course has fluctuated with improvement and worsening of aphasia and epilepsy; at the end of the follow-up the boy was seizure-free and a medium-degree disturbance in language production and comprehension was present. The results of the linguistic evaluation suggest that the aphasic disturbance was related to a deficiency in phonological decoding which leads to phonological, morphosyntactic and lexical disturbances. A temporal relationship between the electroclinical picture and the aphasia has been observed: the persistent improvement in linguistic performances took place only after the disappearance of the seizures and of the EEG epileptic anomalies during sleep.

Adolescent↗

PubMed1986

Development of language comprehension in preschool children: a picture identification test in the assessment of the comprehension of grammatical structures.

A language comprehension test based on picture identification was administered to 180 normal children aged between 3 1/2 and 6 years. Of the 20 test items 11 correlated with age and with the development of linguistic abilities. The test is sufficiently discriminant in respect of comprehension of morphological-syntactic structures between the ages of 4 and 6 years.

Child↗

PubMedDate not supplied

Biological monitoring of fluctuating occupational exposures to styrene.

Nine workers occupationally exposed to styrene producing refrigerator lorries were analyzed. The styrene exposure was monitored 8 hours a day, for 5 days a week, for 1 week. We collected from workers a urine sample before and after each work shift. Moreover, alveolar air samples were obtained at the end of all work shifts. On Thursday afternoon and on Friday morning blood samples were taken from workers. The relationship between styrene exposure and biological data is reported and discussed. Alveolar, urinary and blood concentrations of styrene were comparable, suggesting similar kinetics. Biological styrene concentrations were significantly correlated with the mean daily environmental concentrations, but higher correlation coefficients were found with afternoon exposures. A narrow linear relationship between alveolar (Y) and urinary (X) styrene concentrations was found (Y = 0.359; r = 0.8579; n = 45; p less than 0.001). Urinary concentrations of mandelic acid (Y) confirmed a good relationship with the mean styrene exposure (X) (Y = 2.7 x +169; r = 0.4677 n = 45; p less than 0.01).

Air Pollutants, Occupational↗