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Biomedical subjects

G Zehetbauer

Publications and source records attributed to G Zehetbauer.

At least 19 recordsLinked to original sources
PubMed1983

The effect of timolol on the concentrations of albumin and IgG in the aqueous humor of the human eye.

We investigated albumin and IgG concentrations in the aqueous humor of 41 patients before intracapsular cataract extraction (primary samples) and at the end of surgery (secondary samples). Albumin and IgG concentrations were determined in all samples by means of a quantitative fluoroimmunoassay. A short-term topical application of timolol in 24 eyes was associated with a significant increase in both proteins in the primary aqueous humor samples compared with 17 control samples (P less than .005). The ratios of albumin to IgG--even when corrected for serum levels--were not significantly different in the two groups. Timolol did not affect the change in these ratios in the secondary aqueous humor samples. Thus, we concluded that these findings were not caused by a breakdown of the blood-aqueous barrier, but rather resulted from reduced aqueous humor flow and undisturbed protein filtration.

Aged↗
PubMed1980

The effect of acetyl-salicylic-acid pretreatment on re-formed aqueous humor. A study of intracapsular lens extraction in the human eye.

Aqueous humor (a.h.) was sampled in 67 patients operated on for cataract by intracapsular lens extraction at the start and finish of surgery. Twenty eight of these patients received pretreatment with acetyl-salicylic acid (ASA), to a total of 2.5 g, beginning 18 hours prior to surgery. A serum sample was drawn immediately following the operation from 55 patients. Using radial immunodiffusion, albumin and IgG were measured in primary and secondary a.h. and in serum. The group pretreated with ASA showed a significantly smaller relative increase of IgG (P < 0.05). The increase of the proteins, however, showed no dependence on their serum-level and the only side-effect of the treatment was an unexplained rise in serum-albumin. The possible clinical application of patients with a high risk of postoperative complications is briefly summarized.

Aqueous Humor↗
PubMed1980

[Problems arising from the use of cosmetics on the lid margin (author's transl)].

Report on clinical and histopathological changes of the conjunctiva after long-term use of cosmetics containing carbon black (mascara, eyeliner) on the lid margin. Penetration of tiny pigmented particles into the stroma of the conjunctiva initially causes a follicular reaction which is evidently toxic, and later, results in a chronic follicular-papillary reaction.

Cosmetics↗
PubMed1979

Immediate changes in protein-concentration in aqueous humor induced by intracapsular lens extraction in human eyes.

In 71 patients that underwent intracapsular extraction of the cataract it was possible to collect aqueous humor (a.h.) in sufficient quantities at the beginning and at the end of the operation. Using radial immunodiffusion albumin, IgG and alpha-1-antitrypsin were measured in the samples. In secondary a.h. huge variations in the concentrations were apparent. The primary permeability of the blood-aqueous barrier and the time between sampling had no influence on the relative increase of the proteins. No statistically significant difference was found between normotensives and hypertensives and patients with or without myopia of higher degree (over 6 diopters). The relative increase of proteins according to their difference in molecular weight followed the same pattern as described for anterior uveitis. In patients for whom an enzymatic zonulolysis with trypsin was used for the extraction, the relative increase of IgG was significantly smaller than in those that did not receive this treatment (P less than 0.005). The possible sources contributing to the formation of secondary a.h. are discussed.

Aged↗
PubMed1978

The blood-aqueous barrier and its permeability for proteins of different molecular weight.

In aqueous humors and sera from 44 patients with cataracts, albumin, IgG, and alpha-1-antitrypsin were measured using radial immunodiffusion. The mean concentrations of the three proteins were significantly smaller than values found in aqueous humors taken post mortem, but corresponded well to values found in cerebrospinal fluid. No statistically significant difference was found between men and women, normotensives and hypertensives, and patients with or without myopia of high degree (greater than 6 diopters). A slight increase in protein concentrations in older patients and a relative decrease of alpha-1-antitrypsin is described. The aqueous humor-serum quotients of the different proteins showed a higher correlation than did the concentration of the proteins in aqueous humors.

Aged↗
PubMed1978

[The influence of gravity on the distribution of fat embolism in the eye (author's transl)].

In human fat embolism we often find different grades of changes in both eyes of a patient. This was experimentally verified in rabbits. The anesthetized animals were held in lateral position so that one eye was continuously higher than the other. Labelled fat was injected intravenously, and then the activity in each eye was measured by a scintillation-counter. By this method a significantly higher rate of fat embolism was found in the upper eye.

Animals↗
PubMed1977

[Depressor effect and primary resistance of the cornea against Pseudomonas pyocyanea (author's transl)].

As Ps. pyocyanea seems to replace previously dominant germs as the main cause of corneal infections, the influence of Chloromycetin and actinomycin D on the primary resistance of the cornea and the so-called depressor effect of corneal superinfection with Ps. pyocyanea was tested. The experimental results showed that primary resistance of the mouse cornea against Ps. pyocyanea could be reduced by local application of Chloromycetin drops, but not by actinomycin D. Likewise, the depressor effect of corneal superinfection by Ps. pyocyanea could be significantly reduced by Chloromycetin, whereas actinomycin D had no influence.

Animals↗
PubMed1977

[Immunity after newcastle disease in man (author's transl)].

5 patients, in whom Newcastle disease was diagnosed on the basis of a positive haemagglutination inhibition test (HIT) following contact with affected chickens in 1970 were re-examined recently. The ophthalmological findings were negative at follow-up in all cases. The HIT was still positive (1 : 8) in one patient only; no antibodies were detected in the other four patients.

Animals↗
PubMed1977

[Ophthalmologic follow-up examination in galactosemia (author's transl)].

In 1966, Thalhammer foundet "The Austrian Newborn Screening Program." Since 1969, we have examined 18 infants with galactosemia at 6 month to 8 year intervals. Even dense lens opacities often disappear with the correct dietary adjustment; progression of the cataract indicates failure to adhere to the prescribed diet.

Cataract↗
PubMed1976

[The influence of vitamin A deficiency on the electrooculogram (author's transl)].

Hypovitaminosis A caused by a malabsorption syndrome had led to nearly selective disturbance of rod function in a 30 years old female. No rod dark-adaptation could be recorded. The b-wave in the ERG was lacking and the EOG was flat. The cone function appeared to be unimpaired. This could be documented by normal cone-ERG, colour vision, visual acuity and central visual fields. Following treatment with vitamin A the subjective dark-adaptation, the b-wave in ERG and the EOG recovered. The results show that cones contribute barely to the oscillations of EOG.

Adult↗