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Biomedical subjects

G Zoccali

Publications and source records attributed to G Zoccali.

5 recordsLinked to original sources

Gorlin syndrome associated with basal cell carcinoma of the vulva: A case report.

Gorlin syndrome, also known as nevoid basal cell carcinoma syndrome (NBCCS), is a hereditary condition transmitted as an autosomal dominant trait with high penetrance and variable expressivity. The syndrome is characterized by numerous manifestations: basal cell carcinomas (BCCs) and odontogenic keratocysts (OKCs) are the leading ones. In this article a typical Gorlin syndrome case associated with basal cell carcinoma of the vulva is described.

Aged, 80 and over↗

Comparative evaluation of the haemodynamic effects of continuous negative external pressure (CNEP) and positive end-expiratory pressure (PEEP) in mechanically ventilated trauma patients.

OBJECTIVE: To compare the haemodynamic effects of identical values of continuous negative external pressure (CNEP) and positive end-expiratory pressure (PEEP) in a group of mechanically ventilated patients. SETTING: General ICU, Vicenza Hospital, Italy. PATIENTS: 15 consecutive patients, admitted after road accident trauma. METHODS: We compared the haemodynamic effects of ZEEP, 10 cmH2O of PEEP, and 10 cmH2O CNEP, applied in random order, in 15 head trauma patients under going controlled mechanical ventilation; 9 had associated thoracic trauma, while 6 did not have lung involvement. CNEP was obtained with a "poncho". RESULTS: We observed a significant increase in CI during CNEP, compared with both ZEEP and PEEP 10 cmH2O. Accordingly the oxygen delivery index significantly increased during CNEP, compared with PEEP 10 cmH2O. Conversely, Qs/Qt decreased with CNEP, if compared with PEEP, both in patients with and without lung damage. CONCLUSION: CNEP can significantly increase CI in mechanically ventilated patients in patients with and without associated lung damage.

Blood Gas Analysis↗

Achievements and new directions in continuous renal replacement therapies.

The evolution of renal replacement therapy has permitted the treatment of critically ill patients with acute renal failure. In intensive care settings, continuous renal replacement therapies have been shown to be better tolerated and clinically useful. Continuous hemofiltration is now performed with blood pumps and double-lumen venous catheters, thus avoiding the complications found in previous arteriovenous treatments. The use of countercurrent dialysate flow has overcome problems related to low treatment efficiency. High clearances can now be obtained during continuous hemodialysis or hemodiafiltration, and adequate blood purification can be achieved even in severely catabolic patients. New replacement solutions allow for a more effective correction of acidosis and electrolyte imbalances. Finally, newly designed machines permit continuous therapies while minimizing staff workload. Continuous therapies are today moving toward newer indications and applications. The ability to remove proinflammatory substances by filtration and/or adsorption has opened a series of potential indications. The concept that renal support and protection take place during hemofiltration suggests that very early use of this technique is desirable, even before the onset of oliguria or azotemia.

Acute Kidney Injury↗