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G de Montis

Publications and source records attributed to G de Montis.

At least 37 records · Page 2Linked to original sources
PubMed1989

Serum thymic hormone thymulin activity is normal in children with asthma.

In asthma, it has been hypothesized that suppressor T-lymphocytes play a protective role and have been reported to be functionally abnormal. Thymic hormone thymulin plays a role in the differentiation of T-lymphocytes and plasmatic thymulin concentration and is related to the functional state of the thymus. To assess the participation of the thymus in the impairment of T-lymphocyte function, we measured plasma thymulin activity in children with allergic asthma (N = 40). The plasma thymulin activity was compared with plasma thymulin activity of children with nonallergic asthma (N = 6), children with atopic dermatitis (N = 9) or allergic rhinitis (N = 7), and in age-matched healthy control children (N = 18) (age range of children studied, 2 to 19 years). Thymulin activity was found within the normal range (1/16 to 1/64) in all control children and in all children with allergic asthma and allergic rhinitis, as well as in all children with intrinsic asthma and atopic dermatitis. Our findings are at variance with the low thymulin activity previously reported in allergic asthma, and we could not explain these discrepancies. (Both studies used the same bioassay, and the population studied did not appear to be different.) T-lymphocyte abnormalities in subjects with asthma must be assessed by other means than measurement of thymic function.

Adolescent↗
PubMed1989

[Prognosis in atopic dermatitis].

The author recalls the difficulties of epidemiological enquiries in these conditions: sometimes minimal clinical expression, evolution prolonged and/or recurrent, thus the diagnosis is not only medical but may directly originate from the relatives, it is often the case that atopic dermatitis is grouped together with constitutional eczema and confused by the public with eczema, an popular conception that covers many skin lesions. From the bibliography, the prognosis cannot dbe determined accurately. Passage to asthma, with or without persistence of the skin lesions is the greatest fear when the dermatitis is severe. It is often a question of serious asthma. These uncertainties probably arise from the fact that these affections are syndromes artificially collected under the name of atopy. Clarification will only come if the field of atopy is derived according to the functions of the various causal pathophysiological mechanisms.

Cohort Studies↗
PubMed1987

[RAST and acari in stored goods].

During a multicentre trial, responses of serum from 60 asthmatic children with allergy to the mite Dermatophagoides pteronyssinus (D1) were compared to D. farinae (D2) and 4 storage mites. The known cross reaction between D1 and D2 was confirmed but no such reaction was found between D1 and/or D2 and the storage mites. Because the important cross reactivity between storage mites, the choice of the allergen will depend on the historical and epidemiological data of the disease.

Acari↗
PubMed1986

[Genetic factors in asthma].

Asthma is universally accepted as a multifactorial disease. So the research of constitutional risk factors must consider multiple pathways. In non atopic asthma several rare genetic etiologies are known, others are suspected but not proved. From HAMBURGER atopic allergy is a phenotype with several mechanisms. Finally some data suggest that bronchial hyper-reactivity has a genetic part. The author reviews recent knowledge and describes his personal research. His findings reveal that HLA-B 12 is significantly linked with family history of presumed atopic respiratory disease. These data are discussed.

Adolescent↗
PubMed1982

Glycine receptors in the human substantia nigra as defined by [3H]strychnine binding.

Specific [3H]strychnine binding was used to identify the glycine receptor macromolecular complex in human spinal cord, substantia nigra, inferior olivary nucleus, and cerebral cortex. In material from control patients a high-affinity KD (3--8 nM) was observed in the spinal cord and the substantia nigra, both the pars compacta and the pars reticulata. This is very similar to the values observed in the rat and bovine spinal cord (8 and 3 nM, respectively) and rat substantia nigra (12 nM). In the human brain the distribution of [3H]strychnine binding (at 10 nM) was: spinal cord = substantia nigra, pars compacta greater than substantia nigra, pars reticulata = inferior olivary nucleus greater than cerebral cortex. The binding capacity (Bmax) of the rat brain (substantia nigra or spinal cord) was approximately 10-fold that of the human brain. [3H]Strychnine binding was significantly decreased in the substantia nigra from Parkinson's disease patients, both in the pars compacta (67% of control) and the pars reticulata (50% of control), but not in the inferior olivary nucleus. The results were reproduced in preliminary experiment in rats with unilateral 6-hydroxydopamine lesions of the medial forebrain bundle. In the substantia nigra from patients who died with Huntington's disease, [3H]strychnine binding tended to be high (150% of control, NS) in both the pars compacta and the reticulata. [3H]Strychnine binding was unaltered in the substantia nigra of patients with senile dementia. Together with previous neurophysiological and neuropharmacological findings, those results support the hypothesis of glycine receptors occurring on dopamine cell bodies and/or dendrites in the substantia nigra.

Adult↗
PubMed1981

The importance of the rhesus c factor in determining possible future allergic disease in children.

The author compares the occurrence of rhesus phenotypes CC, Cc and cc in a group of 437 children presenting a reaginic respiratory allergy in function of family antecedents. In children with no family histories of respiratory allergy there exists a significant increase in the frequency of the phenotype cc. The mechanism by which rhesus factors act in respiratory allergy is not known.

Adolescent↗