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Biomedical subjects

G de Venecia

Publications and source records attributed to G de Venecia.

15 recordsLinked to original sources
PubMed1994

Macular heterotopia in proliferative diabetic retinopathy.

Macular heterotopia secondary to proliferative diabetic retinopathy has been previously reported in clinical cases. To our knowledge, we present the first clinicopathologic case of macular heterotopia in a young patient with proliferative diabetic retinopathy. The significant pathologic findings included dense fibrovascular tissue on the disc to correspond with nasal tractional retinal detachment, a superonasally displaced fovea, and an area of stripped and recoiled internal limiting membrane overlying a retinal fold. In addition, an area of reduplicated retinal pigment epithelium was noted corresponding to the clinically observed hyperpigmented area superior to the heterotopic fovea. Despite the pathologic changes, the patient maintained 20/40 visual acuity with the heterotopic fovea for several years. The findings are discussed in relation to previous clinical studies.

Adult↗
PubMed1984

The eye in accelerated hypertension. II. Localized serous detachments of the retina in patients.

Hypertensive choroidopathy was noted in seven patients with accelerated or malignant hypertension. The acute lesion consisted of white areas of retinal pigment epithelial necrosis with overlying serous detachments of the retina. The detachments varied in size. Fluorescein staining of the damaged pigment epithelium and leakage into the subretinal space were demonstrated in several of these patients. Medical control of the BP resulted in a rapid disappearance of the detachment with minimal permanent ophthalmoscopic changes. Reperfusion of the choriocapillaris was suggested by the fluorescein angiogram. Patients with poor control of BP demonstrated at old sites of serous detachments more extensive retinal pigment epithelial pigmentary changes. Some lesions show a central hyperpigmented core surrounded by pigment atrophy (chronic Elschnig's spots). We suspect that choroidal vascular changes predominate when acute elevation of BP is present, whereas a more gradual onset of hypertension results in retinal vascular changes.

Adult↗
PubMed1980

The eye in accelerated hypertension. I. Elschnig's spots in nonhuman primates.

The acute form of Elschnig's spots was produced in a rhesus monkey with experimentally induced accelerated hypertension. Clinically, Elschnig's spots appeared within 24 hours of hypertension as discrete, whitish, subretinal lesions located in the temporal posterior poles of both fundi. The lesions leaked fluorescein. Morphologically, they consisted of complete obstruction of terminal choroidal arterioles and choriocapillaris by fibrin thrombi, necrosis of the retinal pigment epithelium, and fibrinous exudation into Bruch's membrane and into the subpigment epithelial and subretinal spaces. Most of the neurosensory retina was spared from morphologic damage. The differential susceptibility between choroidal and retinal vessels is explained by differences in anatomy and in autonomic nervous control.

Animals↗
PubMed1980

Optic disk vasculitis.

A 44-year-old woman developed progressive loss of vision associated initially with a swollen optic disk, and later with optic atrophy and a diffuse retinal vasculopathy, which caused extensive retinal hemorrhagagic. Histopathologic examination showed hemorrhagagic infarction of the retina, as well as infarction of the anterior optic nerve. In the optic nerve, the central retinal vessels showed extensive phlebitis and occlusion of many small arterioles.

Adult↗
PubMed1979

Retinal wrinkling and macular heterotopia in diabetic retinopathy.

Retinal wrinkling of the posterior pole was studied in 40 eyes from 31 patients with diabetic retinopathy. Vitreoretinal traction was thought to produce the wrinkling in 32 of the eyes, in 13 of which macular heterotopia also developed, presumably from the same tractional forces. Epiretinal membrane formation was the apparent causal factor producing retinal wrinkling in six eyes and postphotocoagulation chorioretinal scarring in two eyes, in none of which macular heterotopia developed. Retinal wrinkling alone was associated with only mild or no visual acuity loss. Macular heterotopia was associated with more severe loss of visual acuity and with other visual symptoms. Displacement of retinal vessels was an important clue to the diagnosis of macular heterotopia.

Adult↗
PubMed1978

Meningeal carcinomatosis with blindness.

A 53-year-old man had bilateral blindness secondary to meningeal carcinomatosis from pulmonary adenocarcinoma. Histopathologic examination of the visual system showed extensive infiltration of the arachnoid of the proximal optic nerves and chiasm, with minimal invasion of the optic nerves themselves. The visual pathways within the cerebral cortex were not affected.

Adenocarcinoma↗
PubMed1978

Septic choroiditis with serous detachment of the retina in dogs.

The present study describes a model of multifocal septic choroiditis with serous retinal detachment after intracarotid injection of Staphylococcus aureus or Streptococcus faecalis. The fundus lesions occurred mainly in the tapetal area and, on ophthalmoscopic examination, were more extensive after S. aureus than after S. faecalis injection. On histopathologic examination there were microabscesses in the inner choroid and subretinal space, disrupting the outer retina but sparing the inner retina.

Animals↗
PubMed1977

Clinicopathologic correlations in diabetic retinopathy. II. Clinical and histologic appearances of retinal capillary microaneurysms.

One eye of a 21-year-old patient with proliferative diabetic retinopathy was available for clinicopathologic correlation. The fluorescent spots in a fluorescein angiogram were correlated with the changes in color fundus photographs and with the corresponding histologic findings in a trypsin digest preparation of the retina. A round, regular fluorescent spot was the most reliable diagnostic indicator of retinal capillary microaneurysms, although some microaneurysms appeared as irregular fluorescent spots, tiny fluorescent spots, or dark silhouettes with or without fluorescent halos. Very large fluorescent spots correlated with very large irregular pouches that may represent intraretinal neovascularization. Fluorescein angiography was considerably more sensitive than color fundus photography for the detection of retinal capillary microaneurysms.

Adult↗
PubMed1977

New neurological findings in trisomy 13.

The patient in this report had many of the classic neuropathologic stigmata of trisomy 13, including retinal dysplasia, arrhinencephaly, holoprosencephaly, single external nare and granular cell heterotopias in the cerebellum and microthalmia. In addition, several new findings apparently were present in this case. The neuropathologic entities were as follows: (1) herniation of the cochlear nuclei into the eighth cranial nerve bilaterally to the transition of central to peripheral myelin; (2) gray matter present in eleventh cranial nerve bilaterally; (3) arteriovenous malformations of letpomeningeal and intracerebral vessels; (4) arachnoid cyst at the cauda equina; and (5) retinal pigment epithelium within the optic nerve.

Accessory Nerve↗
PubMed1976

Ocular and cerebral involvement in familial lymphohistiocytosis.

A 5-month-old infant girl died of familial lymphohistiocytosis. The central nervous system showed widespread perivascular infiltration of the cerebral pia and arachnoid, the cerebral white matter and deep gray matter, the cerebellum, and brain stem by lymphocytes, benign appearing histiocytes, and macrophages with erythro-and lymphophagocytosis. The eyes had mild infiltration of the anterior uveal tract, moderate involvement of the inner retina, and marked infiltration of the optic nerves by identical cells.

Brain↗
PubMed1976

De novo lesions in presumed ocular histoplasmosis-like syndrome.

Two patients with multifocal choroiditis similar or identical to POHS are presented. Colour photographs and fluorescein angiography document the occurrence of de novo lesions in the originally involved eye. The cases also demonstrate the development of new choroidal lesions within the originally involved eye, the early evolution of the "basic choroidal lesion", and the need for fluorescein angiography for visualizing the underlying choroidal lesion.

Adult↗