Biomedical subjects

G van Herk

Publications and source records attributed to G van Herk.

2 recordsLinked to original sources

PubMed1978

Nephroptosis and kidney function.

We have investigated the influence of renal mobility on both renal blood flow and glomerular filtration, in order to evaluate its role as a potential intermediate cause of hypertension. In 25 untreated patients we compared between recumbent and upright position the relative change in the following five parameters: effective renal plasma flow (ERPF), glomerular filtration rate (GFR), renal mobility, peripheral plasma renin activity (PRA) and blood pressure. We found a positive correlation between the degree of renal mobility and an observed decrease in ERPF. On the other hand, no relation was found between the former and an observed decrease in GFR. The PRA appeared to rise following the decrease of the ERPF. These observations suggest that renal mobility adds to the orthostatic reduction in renal blood flow.

Adult↗

PubMed1978

Unilateral kidney blood flow measurement using the 81Rb/81mKr ratio.

A new method has been developed for the continuous quantification of kidney blood flow, utilizing the unique physical and biological properties of the radioactive tracer couple: rubidium-81/krypton-81m. After intravenous injection, 81Rb concentrates primarily in the kidneys, where it continuously generates the radioactive inert gas 81mKr. This ultrashort-lived isotope is continuously washed out from the tissue at a rate proportional to the blood flow. The radiation emitted from within the kidney is externally detected and analyzed to yield the 81Rb/81mKr ratio. 21 animal experiments have confirmed that this ratio is at any time an accurate measure of the kidney perfusion. The 81Rb/81mKr ratio method has proved to provide a non-invasive way to selectively quantify the blood flow in each kidney, to monitor perfusion changes and to image the distribution of blood flow in a functional scintigram.

Animals↗