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Biomedical subjects

G van Vliet

Publications and source records attributed to G van Vliet.

9 recordsLinked to original sources
PubMed1991

Growth hormone treatment of Turner syndrome patients with insufficient growth hormone response to pharmacological stimulation tests.

Growth before and during treatment with biosynthetic human growth hormone (hGH) was studied in 13 patients with Turner syndrome (TS) and a growth hormone (GH) response of less than 10 micrograms/l to two standard provocative tests. During 1 year of treatment with hGH (0.15 IU/kg per day) height velocity (mean +/- SD) increased significantly (P less than 0.001) from 3.7 +/- 1.8 cm/year to 7.6 +/- 1.5 cm/year. The auxological data in these girls before and during treatment with hGH were similar to those observed in TS patients with a normal response of GH to pharmacological stimuli. It is concluded that in girls with Turner syndrome GH testing should only be performed when height velocity is below the Turner norm. In TS patients with residual growth potential a clinically significant growth acceleration can be obtained with a higher-than-replacement dose of hGH, i.e. 0.15 IU/kg per day, regardless of GH testing.

Adolescent↗
PubMed1990

Growth-promoting effect of growth hormone and low dose ethinyl estradiol in girls with Turner's syndrome.

Forty patients with Turner's syndrome, aged 5.0-16.6 yr, were randomly allocated to receive daily sc injections of recombinant human GH (hGH) at a dose of 1 IU/kg.week alone (group I) or in combination with 25 ng/kg.day ethinyl estradiol (E2; group II). The mean pretreatment height velocity was 3.8 cm/yr for both groups. During the first year of treatment height velocity increased significantly (P less than 0.001) in both groups, to 7.5 +/- 1.3 and 8.1 +/- 1.6 cm/yr, respectively. The difference between the two groups was not significant. The mean (+/- SD) height velocity expressed as the SD score for chronological age (Turner references) was 0.0 +/- 1.2 for group I and 0.2 +/- 1.4 for group II and increased significantly (P less than 0.001) during the first year of treatment to +4.3 +/- 1.1 in group I and +5.4 +/- 1.2 in group II. The difference between both groups was statistically significant (P less than 0.01). Height SD score for chronological age (Turner references) increased from -0.2 +/- 0.9 to +0.6 +/- 1.0 in group I and from -0.2 +/- 1.0 to +0.7 +/- 1.1 in group II. Mean bone age progressed similarly in both treatment groups (1.1 +/- 0.6 yr during 1 yr of treatment). However, bone age maturation accelerated more rapidly in younger patients. Twelve girls (three in group I and nine in group II) had minor breast development. No major adverse effects were reported. We conclude that daily sc therapy with hGH stimulates height velocity in Turner's syndrome. The beneficial effect on height velocity increment of E2 addition was small. Furthermore, even very low doses of E2 may induce breast development at an early age and accelerate bone maturation. For these reasons, the addition of E2 to hGH is not warranted in young patients with Turner's syndrome.

Adolescent↗
PubMed1983

[Lungworm disease in cattle, a persistent problem?].

From the results of a number of studies it is concluded that: (1) Cattle of a large proportion (approximately 80 per cent) of the dairy farms in the Netherlands were infected with L3 larvae of Dictyocaulus viviparus during the grazing season in 1981. (2) Experiments showed a significant negative cubic effect on the level of infection with L3 larvae of D. viviparus on the growth of calves. (3) Sporangia of Pilobolus kleinii harbouring L3 larvae were shot significantly further away than sporangia not harbouring L3 larvae.

Animals↗
PubMed1980

[The value of lungworm vaccination in calves (author's transl)].

Although the lungworm vaccine was found to be useful under field conditions, some questions remain, particularly epidemiological ones. Experiments with housed and grazing calves were carried out to elucidate a number of these problems. From these experiments in which vaccinated and unvaccinated calves were challenged, it was apparent: 1. that the immunity developed by vaccinated calves could resist a heavy challenge without clinical symptoms; 2. that vaccinated calves exposed to a heavy challenge could produce small numbers of lungworm larvae. It was shown that, despite the hard winter of 1978/1979, infectious lungworm larvae were present on the pasture in the spring of 1979.

Animals↗
PubMed1979

Mauriac syndrome: three cases with retinal angiofluorescein study.

Three children with features of the Mauriac syndrome have been studied. Ocular complications, mainly characterized by increased capillary permeability have been demonstrated by fluorescein angiography. A decreased proximal tubular beta 2-microglobulin reabsorption has been found in one patient, and in another one, there was a slowed sensory nerve condition velocity. A liver biopsy, performed in one patient, has shown numerous fat filled cells and intralysosomal lipofuscin storage. No hormonal disturbance, which could explain the growth reardation, has been found. Bad metabolic control of diabetes could be responsible for all the anomalies of Mauriac syndrome.

Adolescent↗