Biomedical subjects

Géza Hegedüs

Publications and source records attributed to Géza Hegedüs.

3 recordsLinked to original sources

PubMed2004

[Viral co-infections in hepatitis C: HBV, HBV-C/HGV and TTV studies].

BACKGROUND/AIMS: The prevalence of co-infections with hepatitis B virus (HBV) and novel hepatitis viruses GBV-C (Hepatitis G virus, HGV) and TT virus (TTV) in chronic hepatitis C (HCV) infection has been studied. In patients with chronic hepatitis C and in asymptomatic healthy HCV carriers, the influence of these agents on the course of HCV infection was assessed. METHODS: a total of 110 HCV-positive individuals, among them 77 patients with chronic hepatitis C--50 of them treated with interferon (IFN)--and 33 HCV carriers with normal alanine aminotransferase have been investigated. HBV-DNA, HGV RNA and TTV DNA were detected by PCR, to determine HBsAg and anti-HBc ELISA technic has been used. RESULTS: In the healthy population, the prevalence of anti-HCV was 0.3%, HBsAg 0.09%, anti-HBc 2.5%, HGV RNA 8.0% and TTV DNA 18.5%, respectively. In chronic hepatitis C HBsAg (accompanied with HBV-DNA) occurred in 1.29%, anti-HBc 25.97%, HGV RNA in 9.09% and TTV DNA in 40.25% of cases. In IFN-treated patients with sustained remission, the frequency of TTV was 20% vs. 45.7% found in non-responders. Among asymptomatic HCV-carriers, the prevalence of anti-HBc was 27.27%, HGV RNA 9.09% and TTV DNA 75.7% respectively. CONCLUSIONS: Neither previous HBV infection, nor HGV RNA and TTV DNA had apparent effect on the course of chronic HCV infection. TTV was detected with the lowest frequency in persons with sustained remission due to IFN, suggesting antiviral effect of IFN on TTV.

Adolescent↗

PubMed2004

[Endoscopic placement of self-expanding metal stent for malignant colorectal obstruction].

AIM: 15-20% of the patients with colorectal carcinoma is admitted to hospital with symptoms of colonic obstruction. If urgent, subtotal colectomy can not be done, Hartmann operation is performed, that means diverting colostomy and resection followed by a later re-anastomosis. In this article the authors report on the placement of a self-expandable stent for decompression of a malignant colorectal obstruction, which allows elective one stage resection of the tumour affected segment. PATIENTS AND METHODS: A 63-year-old male patient was admitted with clinical and radiological symptoms of ileus. A total obstruction was found by irrigoscopy at the rectosigmoid transition. An atraumatic guide wire, and a balloon catheter were introduced through the stenotic segment and dilated to 15-mm in diameter. Following that the stenosis was bridged with a SX Ella type, 25-mm diameter, nitiol stent. RESULTS: After the placement of the metal stent the obstruction ceased. Stabilisation of the condition of the patient, proper pre-operative decompression, definition of the tumour stage, appropriate preparation of the patient for the operation became possible. After elective, primary resection the patient recovered without complications. DISCUSSION: There are two main indications for the application of metal stents in colorectal obstructions. One of them is temporary, preoperative decompression in malignant colorectal obstruction. The other one is the palliative treatment of inoperable, malignant large bowel obstructions. In the latter case more complications have to be considered. CONCLUSIONS: Metal stent therapy is an effective and non-invasive, alternative method for preoperative or palliative treatment of malignant colorectal obstructions.

Colonoscopy↗

PubMed2002

Decrease in CD3-negative-CD8dim(+) and Vdelta2/Vgamma9 TcR+ peripheral blood lymphocyte counts, low perforin expression and the impairment of natural killer cell activity is associated with chronic hepatitis C virus infection.

BACKGROUND/AIMS: As chronic hepatitis C virus (HCV) infection is associated with impaired natural killer (NK) cell cytotoxicity, we examined the phenotypes and perforin expression of peripheral blood lymphocytes, as well as the effect of interferon-alpha2b (IFN-alpha2b) therapy. METHODS: Thirty-three patients had chronic hepatitis C, and of them 12 had been on IFN-alpha2b treatment. Eleven individuals had been treated earlier with IFN-alpha2b and completely cured, and eight were HCV carriers with persistently normal serum alanine aminotransferase. Three-colour flow cytometry was used to measure the percentage of CD3(+/-)CD8+, CD3+CD4+, gammadeltaTcR+, Vdelta2 TcR+, Vgamma9 TcR+, Vdelta1 TcR+, CD3-CD16+, CD3-CD56+, CD19+ and perforin-positive cells. NK cell activity was assessed by single cell cytotoxic and flow cytometric assay. RESULTS: Patients with chronic hepatitis C showed an impaired NK cytotoxicity, decreased percentage of CD3-negative-CD8dim-positive (NK subtype) and Vgamma9/Vdelta2 TcR+ as well as perforin-positive T lymphocytes, compared to controls and to those who were cured from HCV infection. IFN-alpha2b increased NK cell cytotoxicity and the percentage of perforin-positive lymphocytes. CONCLUSIONS: Our findings suggest that in chronic HCV infection a decreased percentage of CD3(-)CD8+, Vgamma9/Vdelta2 TcR+ and perforin-positive T cells and simultaneous decreased peripheral NK activity may contribute to the impaired cellular immune response and the chronicity of the disease.

Adult↗