Biomedical subjects
Publications and source records attributed to GR Newkome.
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The modification of the extended 1 --> 3 anthraquinonoid monomer 1 by substitution of the central aliphatic moiety with a more rigid, aromatic moiety has allowed the syntheses of the new branched building block 6 possessing multiple, internal redox sites. This monomer was used to generate the first tier, dendritic macromolecules 8 and 9, which incorporate different internal redox centers within the infrastructure as well as the traditional peripheral multifunctionality. Using cyclic voltammetry experiments, the electrochemical response and electronic interactions between the two electroactive sites (the anthraquinonoid and nitroaromatic moieties) of these dendritic constructs were explored.
Rigid terpyridine-based building blocks allow easy access to large polymetallomacrocycles (see picture) through a self-assembly process. Such routes are envisioned to provide one-step methods to higher order motifs and facilitate the creation of precisely organized, metal-based networks for new energy storage devices.
In order to examine the permeation of small charged colloids into cavities of like charge, size-exclusion chromatography was carried out with carboxyl-terminated dendritic polymers on a porous glass stationary phase. Chromatographic partition coefficients KSEC were measured for solute diameters ranging from 2 to 8 nm, at neutral pH, and ionic strengths from 0.01 to 0.09 M, and were reported relative to those of noninteracting solutes of equal size (pullulan and Ficoll). The experimental results were compared to values calculated using the treatment of F. G. Smith III and W. M. Deen for charged spheres in cylindrical pores of like charge (J. Colloid Interface Sci. 78, 44 (1980); 91, 571 (1983)). The measured degrees of permeation were typically 20-100% larger than the calculated values, the discrepancies being greatest for the larger solutes at high ionic strength. It is shown that the tendency of the calculations to overestimate the repulsion are likely to arise from linearization of the Poisson-Boltzmann equation.