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Biomedical subjects

Gabriele Moser

Publications and source records attributed to Gabriele Moser.

7 recordsLinked to original sources

[Functional gastrointestinal disorders].

The functional gastrointestinal disorders (FGID) are the most frequent clinical conditions seen in practice. The FGID are associated with significant work absenteeism, impaired quality of life and increased medical costs. Most patients also suffer from psychosocial problems. Therefore it is important to define the patient's complaints in terms of a biopsychosocial disorder rather than just a medical illness. Physicians must acknowledge the relevance of the psychosocial aspects to prepare the patient for a referral to a specialist (in psychosomatic medicine or a psychotherapist) and to get the patient interested in the psychological factors involved as well as further explore their cause. Most of the research on psychotherapy in FGID to date has focused on the irritable bowel syndrome, and different methods of treatments have been studied (e. g., cognitive-behavioral therapy, dynamic psychotherapy, hypnotherapy, and relaxation). Randomised controlled studies have shown that psychotherapy is superior to conventional medical therapy. Hypnotherapy seems to be very successful. Predictors of a positive response to psychological treatment generally are: (1) awareness that stress exacerbates their bowel symptoms, (2) mild anxiety or depression, (3) the predominant bowel symptom is abdominal pain or diarrhea and not constipation, (4) the abdominal pain waxes and wanes in response to eating, defecation, or stress rather than being constant pain, and (5) the symptoms are of relatively short duration. Psychotherapy is initially relatively expensive because it requires multiple, long sessions. However, its benefits persist or even increase over time, and in the long run, there may be a reduction in clinic visits and health care costs which offsets the initial cost of psychological treatment.

Cognitive Behavioral Therapy↗

SAR amplitude probability density function estimation based on a generalized Gaussian model.

In the context of remotely sensed data analysis, an important problem is the development of accurate models for the statistics of the pixel intensities. Focusing on synthetic aperture radar (SAR) data, this modeling process turns out to be a crucial task, for instance, for classification or for denoising purposes. In this paper, an innovative parametric estimation methodology for SAR amplitude data is proposed that adopts a generalized Gaussian (GG) model for the complex SAR backscattered signal. A closed-form expression for the corresponding amplitude probability density function (PDF) is derived and a specific parameter estimation algorithm is developed in order to deal with the proposed model. Specifically, the recently proposed "method-of-log-cumulants" (MoLC) is applied, which stems from the adoption of the Mellin transform (instead of the usual Fourier transform) in the computation of characteristic functions and from the corresponding generalization of the concepts of moment and cumulant. For the developed GG-based amplitude model, the resulting MoLC estimates turn out to be numerically feasible and are also analytically proved to be consistent. The proposed parametric approach was validated by using several real ERS-1, XSAR, E-SAR, and NASA/JPL airborne SAR images, and the experimental results prove that the method models the amplitude PDF better than several previously proposed parametric models for backscattering phenomena.

Algorithms↗

[Psychosomatic aspects of bowel diseases].

Functional gastrointestinal disorders (FGID) and inflammatory bowel diseases (IBD) are the most frequently studied bowel disorders in the context of a bio psycho-social model. FGID are associated with significant work absenteeism, impaired quality of life, and increased medical costs. Many patients also suffer from psychosocial problems. Most of the research in FGID to date has focused on the irritable bowel syndrome. Randomised controlled studies have shown that psychotherapy is superior to conventional medical therapy. The gut-focussed hypnotherapy seems to be very successful. For IBD it is increasingly recognized that the psycho-neuro-endocrine network can modulate inflammation and pain perception and that psychosocial factors are related to exacerbation of and coping with IBD. The psychosocial consequences of the illness become more significant with increasing severity of the disease. Therefore integrated psychosomatic care should be provided, the patient's psychosocial status and the demand for additional psychological care should be assessed and offered, if indicated.

Adaptation, Psychological↗

["A model of joint research"? Cancer research and the funding policies of the German Research Foundation and the Reich Research Council in National Socialist Germany].

In 1936 the German Research Foundation (Deutsche Forschungsgemeinschaft) started planning a programme for tumour research. After discussions between representatives of the German Research Foundation, the Reich Health Office and the Ministry of Science and Education about the extent of the scheme, in December 1936 the first scientists received their grants. The scheme was mainly drawn up by the Munich pathologist Max Borst, who was supported by the German Research Foundation's employee Sergius Breuer. Scientific research on cancer was divided into four sections: (1) etiology, (2) diagnosis, (3) treatment, and (4) constitution, disposition, heredity, and statistics. Well-known German scientists were invited to contribute to the scheme. When the Reich Research Council (Reichsforschungsrat) took over power in decision-making on research funding in 1937, cancer research was not seriously affected. Only in 1943, when further restructuring of the Reich Research Council took place, the situation changed through Kurt Blome's becoming the plenipotentiary for cancer research. Blome's position in cancer research was linked with the task of supporting scientific research on biological and chemical warfare. In general, however, the characteristics of the cancer research scheme remained astonishingly constant up to the end of World War II.

Biomedical Research↗

Assessing the demand for psychological care in chronic diseases: development and validation of a questionnaire based on the example of inflammatory bowel disease.

BACKGROUND: This study was designed to develop and validate the ADAPT (Assessment of the Demand for Additional Psychological Treatment), a questionnaire assessing the demand for disease-oriented counseling (DOC), integrated psychosomatic care (IPC), and psychotherapy (PT) in chronically ill patients on the example of inflammatory bowel diseases (IBDs). METHODS: After its development, the ADAPT was distributed to 39 IBD patients along with the Hospital Anxiety and Depression scale (HAD), the Rating Form of IBD Patient Concerns (RFIPC), and a questionnaire on social support (SOZU-K22). For construct validity, 19 hypotheses were made on how DOC, IPC, and PT should correlate with HAD, RFIPC, SOZU-K22, and disease-related variables. To analyze interindividual responsiveness, patients were classified according to their bio-psycho-social state, and DOC, IPC, and PT scores were compared between these classes. The test-retest method with a 4-week time lapse was used to analyze reliability and intraindividual responsiveness. DOC, IPC, and PT scores between baseline and follow-up were compared separately for patients classified as "stable" or "changed" according to changes in HAD and disease activity. RESULTS: Observed correlations were largely in agreement with the 19 hypotheses. DOC, IPC, and PT achieved significantly different scores between different patients. After 4 weeks, DOC, IPC, and PT revealed stable scores in patients with "stable" HAD and revealed significantly different scores in patients with "changed" HAD. Changed disease activity was not associated with significant changes of the ADAPT. CONCLUSIONS: The ADAPT is the first questionnaire to assess subjective demand for additional psychological care in chronically ill patients. The first application of the ADAPT to 39 IBD patients suggests its validity, reliability, and responsiveness.

Adult↗

Impact of depressive mood on relapse in patients with inflammatory bowel disease: a prospective 18-month follow-up study.

OBJECTIVE: There is evidence of an interaction between psychological factors and activity of inflammatory bowel disease (IBD). We examined the influence of depressive mood and associated anxiety on the course of IBD over a period of 18 months in a cohort of patients after an episode of active disease. METHODS: In this prospective, longitudinal, observational study, 60 patients (37 women and 23 men) with clinically inactive IBD (Crohn disease, n = 47, 78%; ulcerative colitis, n = 13, 22%) were enrolled after a flare of disease. Psychological status, health-related quality of life (HRQOL), and disease activity were evaluated at baseline and then every 3 months for a period of 18 months by means of clinical and biological parameters, the Beck Depression Inventory (BDI), the Spielberger State-Trait Anxiety Inventory, the Inflammatory Bowel Disease Questionnaire, the Perceived Stress Questionnaire, and the Rating Form of Inflammatory Bowel Disease Patients Concerns. RESULTS: At baseline, depression (BDI > or = 13 points) was found in 17 of 60 (28%) patients. Thirty-two patients (59%) experienced at least one relapse during the 18 months of follow-up. Regression analysis showed a significant correlation between BDI scores at baseline and the total number of relapses after 12 (p <.01) and 18 months (p <.01) of follow-up. Furthermore, depression scores at baseline correlated with the time until the first recurrence of the disease (p <.05). Anxiety and low HRQOL were also related with more frequent relapses during follow-up (p <.05 and p <.01, respectively). CONCLUSIONS: Psychological factors such as a depressive mood associated with anxiety and impaired HRQOL may exert a negative influence on the course of IBD. Therefore, assessment and management of psychological distress should be included in clinical treatment of patients with IBD.

Adult↗