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Biomedical subjects

Gang Zhong

Publications and source records attributed to Gang Zhong.

8 recordsLinked to original sources
PubMed2006

[Experimental study on the proliferation and function of osteoblast cell induced by pBLAST49-mVEGF gene transfection].

OBJECTIVE: To assess the effects of extra VEGF gene expression on the proliferation of osteoblast cell. METHODS: The extra VEGF gene was induced into osteoblast cell. Then the expression of extra VEGF gene was detected, and its effects on the cell proliferation curve, cell cycle, on the synthesis of type I collagen and on the secretion of osteocalcium of osteoblast cell were investigated. RESULTS: At the first two days of culture, the cell number of pBLAST49-mVEGF gene transfer group was larger than that of the control group, yet no statistically significant difference was seen between the two groups (P > 0.05); however, significant difference was observed from the 3rd day of culture (P < 0.05). The (G2/M+S)% of the 1-5 generation osteoblast cell in pBLAST49-mVEGF gene transfer group was higher than that of the control group, there was significant difference between them (P < 0.05). The concentration of osteocalcium and expression of type I collagen of the 1-5 generation osteoblast cell in pBLAST49-mVEGF gene transfer group were significantly higher than those of the control group (P < 0.05). CONCLUSION: pBLAST49-mVEGF gene transfer can improve the proliferation and function of osteoblast cell.

Animals↗
PubMed2006

[Neurofibromatosis type 2].

OBJECTIVE: To recognise the predisposing factors, clinical manifestations, diagnosis and treatment of neurofibromatosis type 2 (NF2). METHOD: The clinical data of one NF2 case was reported and the literatures were also reviewed. RESULT: The patient was diagnosed at a much later stage than onset. Progressive hearing loss and tinnitus were the initial symptoms. MRI scan indicated space-occupying lesions in the bilateral cerebellopontine angles, bilateral cavernous sinuses and bilateral cervical parts of the patient. The patient was diagnosed as NF2 according to the National Institutes of Health (NIH) criteria, and received operation on the left acoustic tumor. The tumor was proved to be schwannomas by pathological test. The hearing loss and the facial nerve paralysis (House-Brackmann II) had appeared after operation. CONCLUSION: NF2 is an autosomal dominant, highly penetrant disease which is characterized by bilateral vestibular schwannomas. Early diagnosis and management for tumor is very important for survival and hearing preservation. The "golden standard" in terms of diagnostic precision is the magnetic resonance imaging (MRI) scan with gadolinium enhancement.

Adult↗
PubMed2006

[Ossifying fibroma of the temporal bone].

OBJECTIVE: To describe the clinical presentation of ossifying fibroma of the temporal bone, and to discuss its diagnosis and treatment. METHOD: A rare case of ossifying fibroma of the temporal bone was presented. The patient was a 8-year-old boy with a one year history of left ear discomfort, suppurative otorrhea and progressive hearing loss. Physical examination of the ear revealed a stenosis of left external auditory canal (EAC), and an obvious expansion at mastoid region. Audiometry showed no hearing of the left ear. A postauricular approach was used to expose the mass. Frozen section evaluation during operation was not definitive but suggested benign nature in histology. The tumor was fully resected. The EAC was sealed by sutured skin, and the extended mastoid cavity was obliterated with abdominal fat. RESULT: The final pathological report indicated the stromal cells were negative for S-100 protein and epithelia membrane antigen (EMA), supporting the diagnosis of ossifying fibroma. One-year follow-up showed the sealed EAC was satisfactory with complete interior and no tumor recurred. CONCLUSION: Ossifying fibroma of the temporal bone is a rare entity, which is a benign neoplasm but may show an aggressive behavior by compression and encroachment upon adjacent structures. Early and complete removal was advocated.

Bone Neoplasms↗
PubMed2005

[Twenty four cases of cholesterol granuloma of the paranasal sinuses].

OBJECTIVE: To investigate the etiology and pathogenesis of cholesterol granuloma of the paranasal sinuses and the treatment for the disease. METHODS: Twenty four cases of cholesterol granuloma of the paranasal sinuses treated in our hospital during the period from March 1996 to March 2003 were retrospectively analysed. All cases were verified by surgery and pathology. RESULTS: Of all cases, 10 cases were diagnosed as chronic sinusitis, 8 cases as nasal sinus cyst, and 5 cases as nasal polyp before operation, only 1 case was considered as cholesterol granuloma. The main symptoms were nasal obstruction (20/24), rhinorrhea (18/24), dysosmia (10/24), headache (7/24), pain around the eye (5/24), double vision (2/24), et al. Different surgical approaches were selected depending upon different pathological changes. Good results were obtained in 23 cases and postoperative follow-up for at least one year showed no recurrence. Only one case received revision nasal endoscopic surgery two years after Caldwell-Luc operation because of recurrence, and remained symptom-free for three years. CONCLUSIONS: The pathogenesis of cholesterol granuloma includes obstruction of ventilation and drainage and brooding in sinuses. Cholesterol granuloma of the paranasal sinuses seems to have a close relation with chronic sinusitis, especially sinus mucocele. The surgical approach depends upon the location, extension, and severity of the lesion. The principle of surgery is to eliminate the pathological focus and create an adequate drainage.

Adult↗
PubMed2005

[Vestibular evoked myogenic potentials in normal young people].

OBJECTIVE: To observe the positive rate and other variances of the vestibular evoked myogenic potentials (VEMP)in normal young people. METHOD: Fifty-two normal young people aged from 21-22 years old including 31 males and 21 females were investigated. Intense clicks were given to one test ear and EMG was recorded from ipsilateral side. RESULT: VEMPs were presented in both ears in 47 subjects, absent in either of the two ears in 5 subjects. Variances averaged from all 94 positive ears were as follows (mean +/- standard deviation): latencies for p1 (15.97 +/- 3.22) ms, latencies for n2 (24.41+/- 2.46) ms, interval time between p1 and n2 (8.41 +/- 2.06) ms, amplitude (33.27 +/- 14.37) microV, threshold (93.67 +/- 5.20) dB nHL. Inter-subject variances averaged from 47 normal subjects were as follows:latencies for p1 (0.97 +/- 1.31) ms, latencies for n2 (1.23 +/- 1.30) ms, interval time between p1 and n2 (0.95 +/- 1.21) ms, amplitude (10.04 +/- 11.88) microV, threshold (2.29 +/- 2.56) dB nHL. There were no significant difference between males and females. CONCLUSION: VEMP can be recorded in most normal subjects. VEMP may travel along the hypothesized response pathway from the vestibular sacculus to the inferior vestibular nerve, vestibular nucleus, and lateral vestibulospinal tract to the SCM muscle. VEMP recording could become an attractive method for testing otolithic receptors and vestibulospinal pathways.

Acoustic Stimulation↗
PubMed2003

[The study of the relationship between obstructive sleep apnea syndrome and positional nasal resistance].

OBJECTIVE: To study the nasal resistance in different position and its possible relationship to obstructive sleep apnea syndrome (OSAS). METHOD: The positional rhinomanometry and the detection of polysomnography were performed in 14 normal subjects, 20 snoring patients and 40 patients with OSAS. RESULT: The study reveals that: 1. the nasal resistance in seated position and in supine position of the patients with OSAS but without nasal diseases or snoring patients without nasal disease were higher than that of the normal group (P < 0.05). 2. The nasal resistance in seated position and in supine position of the patients with both OSAS and nasal disease were higher than that of the snoring patients with nasal disease (P < 0.05). 3. The nasal resistance in supine position was higher than the nasal resistance in seated position in all the groups (P < 0.05), even in the patients with OSAS (P < 0.01). 4. The AHI, waken intervals, snoring index of the patients both with OSAS and nasal disease were higher than those of the patients only with OSAS. CONCLUSION: Nasal resistance increased in the patients with snoring or OSAS and increased more in the supine position. Nasal resistance may be an important factor in the pathogenesis of OSAS.

Adult↗