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Biomedical subjects

Gary Butler

Publications and source records attributed to Gary Butler.

4 recordsLinked to original sources
PubMed2005

People with intellectual disabilities and their need for cancer information.

Many people with intellectual disabilities will be affected by cancer in their lifetime. There is a lack of available knowledge about people with intellectual disabilities' understanding and experience of cancer, and about their need for cancer information. The principal aim of the study was to explore the information needs of people with intellectual disabilities who are affected by cancer. This was a qualitative, hypothesis generating study. Nine people with intellectual disabilities who were affected by cancer were identified using a purposive sampling method; five of these participated in the study. Data collection included observation of the use of a pictorial cancer information book designed for people with intellectual disabilities, and semi-structured interviews. Data analysis revealed three themes: (1) "Nobody told me": the desperate need for cancer information; (2) "That reminds me": telling my own story; and (3) "I don't know much about cancer": the difficulties of the staff supporting people with intellectual disabilities to read the cancer information book. The people with intellectual disabilities in this study were not provided with information about cancer. They wanted this information, and appeared to be capable of comprehending it. Further development of accessible information materials around cancer and palliative care is needed.

Adult↗
PubMed2004

An absence of evidence linking perceived memory problems to the menopause.

BACKGROUND: Little is known about the prevalence of subjective or perceived memory difficulties in the general population. This is of particular interest in the field of menopause as self-reported memory difficulties make up a large proportion of complaints by women presenting at specialist menopause clinics. There is also a general assumption that memory problems increase with age. AIM: To investigate the prevalence of perceived memory difficulties in women to establish whether there are variations with menopausal status and age. DESIGN OF STUDY: Cross-sectional questionnaire study. SETTING: Sheffield, United Kingdom. METHOD: Standardised questionnaires assessing subjective memory, mood and menopausal symptoms were sent to a random sample of 400 women, aged 25-64 years, identified from a general practice list. Menopausal status and demographic details were also recorded. Two hundred and two women responded, giving a response rate of 50.5%. RESULTS: The prevalence of perceived memory difficulties was low, and did not differ on the basis of menopausal status or age. Anxiety and depressive symptoms were the main significant predictors of perceived memory difficulties. CONCLUSION: Perceived memory difficulties are not specific to particular stages of the life cycle or age, but are experienced to a greater degree by those with high levels of depressive or anxiety symptoms.

Adult↗
PubMed2002

C1qRp defines a new human stem cell population with hematopoietic and hepatic potential.

The characterization of two distinct classes of hematopoietic stem cells based on CD34 expression and the ability of human bone marrow (BM) cells to differentiate into nonhematopoietic cells introduced new levels of complexity within the stem cell compartment. Here we report the identification and purification of a rare human stem cell population with hematopoietic and hepatic potential based on the expression of a receptor for the complement molecule C1q (C1qR(p)). We show that C1qR(p) is a positive marker of all BM-repopulating stem cells because it is expressed on both CD34(-) and CD34(+) stem cells from umbilical cord blood and adult BM. In addition, we show that highly purified lineage-negative CD45(+)CD38(-)CD34(+or-)C1qR(p)(+) cells not only have BM-repopulating capacity but also can differentiate into human hepatocytes in vivo. The identification of human hepatocytes in mouse livers indicates that the NOD/SCID (nonobese diabetic/severe combined immunodeficient) mouse model can be a valuable tool to study the differentiation potential of adult human stem cells. These findings may have important scientific and clinical implications in the field of human stem cell biology and transplantation.

ADP-ribosyl Cyclase↗