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Biomedical subjects

Gary Goldstein

Publications and source records attributed to Gary Goldstein.

6 recordsLinked to original sources

An evaluation of wear when enamel is opposed by various ceramic materials and gold.

STATEMENT OF PROBLEM: Ceramic restorations have been known to cause wear of opposing enamel. PURPOSE: The purpose of this study was to evaluate enamel wear caused by 3 ceramic substrates in the glazed and polished conditions. MATERIAL AND METHODS: Sixty ceramic discs (10 x 2 mm)-20 each of Finesse, All-Ceram, and IPS-Empress-were prepared and glazed. Each group of 20 was divided into 2 groups of 10. The surfaces of one group were ground and polished using a porcelain polishing kit (Dialite). The remaining 10 were left as glazed. Ten specimens of a type III gold alloy were cast into rectangular shapes of 10 x 12 x 2 mm and polished. Seventy human cusps were prepared from sound, caries-free, extracted teeth and abraded against the substrates in a wear machine for a total of 10,000 cycles. The cusp height loss was traced before and after the wear test using a profile projector. Mean surface roughness (R(a)) values for the substrates were also recorded with a profilometer before testing. Differences in R(a) were evaluated using 1- and 2-way ANOVA and the Scheffe post hoc test (alpha = .05). RESULTS: One-way ANOVA indicated that enamel height loss was significantly different by material (P < .001) and surface condition (glazed and polished or glazed; P < .05). Gold, polished Finesse, and polished All-Ceram were the least abrasive, whereas glazed IPS-Empress was the most abrasive. There was no significant interaction effect between substrate type and surface condition. Significant differences were found when R(a) of the substrate condition was compared with enamel wear (P < .01). CONCLUSIONS: Gold, polished Finesse, and polished All-Ceram caused the least enamel wear, whereas IPS-Empress caused the most wear. Cast gold was significantly different than glazed IPS-Empress (P < .05), whereas other groups overlapped. There was significant correlation between R(a) and enamel wear (P < .01).

Aluminum Oxide↗

In vivo correlation of noncarious cervical lesions and occlusal wear.

STATEMENT OF PROBLEM: The etiology of noncarious cervical lesions is not well understood. An understanding of the etiology helps the clinician determine appropriate treatment and management strategies. Purpose This study evaluated the relationship between noncarious cervical lesions and occlusal (or incisal) wear. MATERIAL AND METHODS: Casts (n = 299) made from dental students were articulated in a semi-adjustable articulator and evaluated. Data included the presence and contour of noncarious cervical lesions (NCLs) and the presence, location, and severity of any occlusal/incisal wear facets. Also included were Angle's classification, occlusal guidance patterns, midline, presence of tori, tooth restoration, reverse articulation (crossbite), open occlusal relationship, and posterior excursive contacts where present. Following a calibration procedure, 2 evaluators made independent observations on the casts. The first evaluator recorded for each tooth in each subject: presence and severity of NCLs, presence and extent of occlusal/proximal restorations, and presence of reverse articulation and open occlusal relationship. Following the first evaluation red rope wax was placed at the cervical margins of each tooth for the purpose of blinding the second evaluator from NCL observations. The second evaluator recorded severity and location of occlusal/incisal wear, presence or absence of posterior excursive contacts, Angle's classification, occlusal guidance pattern, any midline discrepancy, and presence or absence of tori. The Spearman correlation coefficient and chi 2 tests were used to analyze the data (alpha=.05). RESULTS: There was no relationship between noncarious cervical lesions and occlusal/incisal wear. There was also no correlation between NCLs and other parameters examined. CONCLUSIONS: Under the conditions of this study, noncarious cervical lesions are not related to occlusal wear.

Adult↗

Exposure to lead elevates induction of zif268 and Arc mRNA in rats after electroconvulsive shock: the involvement of protein kinase C.

Exposure to lead is well known to impair cognitive function in young children. Because of the importance of gene regulation for neurodevelopment, we examined the effect of lead on the induction of the mRNA of the immediate early genes zif268 and Arc. The time course for the induction of zif268 mRNA and Arc mRNA by electroconvulsant shock (ECS) was altered in the area of the dentate gyrus of the hippocampus in rats exposed to lead from postnatal days (PND) 1 to 28. Other areas of the hippocampus were not affected by lead. The effects on the induction of zif268 mRNA were observed at blood lead levels as low as 12 microg/dl. No change in the induction of zif268 mRNA was observed in the hippocampus of rats exposed to lead from PND 28 to PND 56. Because of the possible involvement of protein kinase C (PKC) in the effect of lead, activation of different isoforms of PKC was investigated. An increase in the amount of PKC epsilon and PKC gamma was observed at 60 min after ECS in the membrane fraction from hippocampus, indicating activation of these isoforms. The amount of PKC epsilon in membranes was higher in rats exposed to lead than in rats not exposed to lead after ECS. Taken together, the data suggest that lead may disturb regulation of specific immediate early genes by activating PKC epsilon.

Animals↗

A shared spirit.

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Animal Technicians↗

Task force on special dentistry makes meaningful improvement.

This article explores the formation of a task force to address the specific issues that confront dentists who treat patients with disabilities. From the first meeting, this all-volunteer task force, with representatives from clinical dentistry, public health groups, hospitals and dental schools, set out to recognize the specific issues that arise with special needs patients and offer workable solutions. This article enumerates these issues, and can serve as a reference for dentists and other health professionals.

Advisory Committees↗