Biomedical subjects

Geoffrey K Saunders

Publications and source records attributed to Geoffrey K Saunders.

5 recordsLinked to original sources

PubMed2006

Effect of nephrotomy on renal function and morphology in normal cats.

OBJECTIVE: To assess effects over 12 weeks of bisection nephrotomy on renal function, size, and morphology in cats. STUDY DESIGN: Controlled, randomized, blinded experiment. SAMPLE POPULATION: Ten adult female cats. METHODS: Glomerular filtration rate (GFR), determined by quantitative renal scintigraphy using (99m)Technetium-diethylenetriamine-pentaacetic acid, urinalysis, urine culture, and ultrasonographic measurement of renal size were performed preoperatively. Left or right nephrotomy (5 cats/group) was performed. Total and individual kidney GFRs were determined at 2, 28, and 84 days, ultrasonographic measurements at 28 and 86 days, and ultrasound-guided biopsy at 86 days. RESULTS: No significant differences in mean GFR and kidney size of operated versus unoperated kidneys were observed. Individual GFR and renal size of all except 1 cat remained within normal limits. Two cats had evidence of transient ureteral obstruction in the immediate postoperative period. No significant, generalized histologic abnormalities were observed. CONCLUSIONS: Bisection nephrotomy in normal cats does not adversely affect renal function or morphology during the initial 12 weeks. CLINICAL RELEVANCE: Bisection nephrotomy can be safely performed in normal feline kidneys without causing a significant deleterious effect on renal function. Studies in cats with pre-existing renal insufficiency are needed to ensure adverse effects would not occur in clinical cases where this surgical procedure is warranted.

Animals↗

PubMed2006

Lymphoma and Mycobacterium avium infection in a ferret (Mustela putorius furo).

A 6-year-old, neutered male ferret presented with weight loss. Radiography revealed an enlarged liver and other abdominal masses. The ferret was euthanized, and at necropsy, the stomach wall was thickened, mesenteric lymph nodes were enlarged, and the liver contained multifocal tan nodules. Histopathology confirmed lymphoma and granulomatous inflammation in all affected organs. Acid-fast bacilli were present in the lesions and were confirmed to be Mycobacterium avium by PCR.

Animals↗

PubMed2004

Fibrocartilaginous embolic myelopathy in a calf.

A 5-month-old Angus heifer with a history of acute hindlimb paresis that quickly progressed to lateral recumbency was necropsied. Gross lesions included a 6-cm segment of gray to brown discoloration and softening of the right ventrolateral spinal cord between T2 and T3. Microscopically, there was liquefactive necrosis of ventrolateral white and gray matter, and multiple intravascular emboli partially or completely occluded many intralesional and adjacent spinal and meningeal arteries and veins. Emboli were alcian blue positive, consistent with fibrocartilage of the nucleus pulposus of the intervertebral disk. No gross abnormalities were detected in the vertebrae or intervertebral disks. Fibrocartilaginous embolic myelopathy appears to be very rare in cattle; however, it should be considered in cases of acute, nonprogressive spinal cord dysfunction.

Animals↗

PubMed2003

Systemic candidiasis in a dog.

Candida albicans is a common cause of nosocomial infections in humans, but there are few reports of systemic candidiasis in dogs. This report describes an 11-year-old spayed female Scottish Terrier with systemic candidiasis. The diagnosis was made on the basis of results of microbiologic culture of specimens from urine and venous catheters and histologic examination of tissues obtained post mortem. Factors that predisposed the dog of this report to systemic candidiasis included diabetes mellitus, corticosteroid and broad-spectrum antimicrobial administration, venous and urinary catheterization, and administration of nutrition parenterally. The development of pyrexia and leukocytosis in dogs with risk factors that predispose to Candida spp infections warrants evaluation via microbial culture of specimens from urine and vascular catheters used in those dogs.

Animals↗

PubMedDate not supplied

Synovial regeneration in the equine carpus after arthroscopic mechanical or carbon dioxide laser synovectomy.

OBJECTIVE: To compare synovial regeneration in the equine carpus after mechanical or CO(2) laser synovectomy. STUDY DESIGN: Arthroscopic partial synovectomy was performed in the radiocarpal and intercarpal joints. SAMPLE POPULATION: Twelve horses, 3 to 6 years of age, were randomly divided into 3 groups. METHODS: The antebrachiocarpal and intercarpal joints in each horse were randomly assigned a treatment such that each horse had one joint treated as a control (arthroscopic lavage), one in which a mechanical or CO(2) laser partial dorsal carpal synovectomy was performed, and one in which a combination of the mechanical and laser techniques was performed. The groups were euthanized for collection of specimens, respectively, at 1, 3, and 6 months postoperatively. The synovial membrane was evaluated grossly, histologically, and by transmission and scanning electron microscopes (TEM and SEM). RESULTS: The synovial villi failed to regenerate in all groups. At 1 month, the intimal cell layer was incomplete and the surface was still granulating. At 3 months, intimal regeneration was complete but more mature in the CO(2) laser synovectomy groups than in the mechanical synovectomy groups. Intimal regeneration was complete in all groups at 6 months. The subintima was replaced with fibrous tissue that separated the original subintimal vascular bed from the regenerated synovial surface. The CO(2) laser required preliminary training to operate effectively, and the air environment altered the intraoperative evaluation of the synovectomy site. CONCLUSIONS: Villous regeneration does not occur in horses after surgical synovectomy. All synovial membranes healed with a fibrous subintima and less populated intima. The CO(2) laser is capable of performing a more superficial synovectomy than that achieved with mechanical synovectomy using a motorized arthroscopic synovial resector. CLINICAL RELEVANCE: Mechanical or CO(2) laser synovectomy may be performed in the horse; however, additional evaluation is needed to determine the physiological significance of the lack of villus regeneration in this species. A combination of the resection techniques is not advised because of the increased risk of full-thickness capsular defects.

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