Priapism and quetiapine in an HIV-positive male.
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Amphetamine-Related Disorders↗
Biomedical subjects
George Harrison
Publications and source records attributed to George Harrison.
Pathophysiological responses of MRC-5 cells exposed to various doses of x-ray radiation.
The numbers of x-ray procedures used as diagnostic tools are on the rise; these procedures are being used more frequently than ever before. The radiation effect from these procedures are said to be minimal, however there is a significant increase in cellular damage that may lead to cellular aberrations. The objective of this study was to expose human lung fibroblast (MRC-5) cells to various doses of x-ray radiation and evaluate its effects on the proliferation and morphology of the cells. Based on the review of the literature, we selected doses similar to other researchers, the doses were 2, 6 and 10 (Gy), evaluated after 24, 48 and 72 hours of incubation. The results indicated a 25% decrease in the cell number after 48 and 72 hours (p < 0.05), in all groups exposed to either dose of radiation. After 24 hours, there was not a statistically significant difference between the groups exposed to either dose of radiation. Morphologically, the cells exhibited significant changes when exposed to either, 2, 6 or 10 Gy of radiation. The cells showed multiple nucleoli with all doses, and mitotic figures were observed with a dose of 2 Gy. After a dose of 6 Gy, hydropic swelling due to excess fluid in the cytoplasm was noted as well as multiple nucleoli. After 48 and 72 hours, severe vacuolization with various degrees of hypertrophy and atrophy was noted with a dose of 10 Gy. Further analysis revealed that the higher the radiation dose, the more severe the damage after 48 and 72 hours, however, significant damage was evident with all doses, even as low as 2 Gy.
Cell Line↗
Priapism and quetiapine: a case report.
Priapism is a "persistent erection not accompanied by sexual desire or stimulation, usually lasting more than six hours and typically involving only the corpora cavernosa." Here we report on a gay male patient from our HIV/AIDS mental health clinic who developed serious priapism on quetiapine and recreational amphetamine. Gay men are at high risk for amphetamine use, and as such, this potential association between priapism, quetiapine, and amphetamine use should be considered in making prescription decisions with these patients.
Amphetamine↗
Overcoming depression.
Depression is one of the most prevalent and undertreated complications of HIV disease. Despite the improvements in health related to highly active antiretroviral therapy (HAART), women and men with HIV continue to be at risk for depression. Untreated depression not only can affect quality of life, but it also may compromise HAART adherence, weaken immune functioning, exacerbate chronic pain, and contribute to substance use. Depression might also lead to sexual risk-taking behavior in some people with HIV, potentially contributing to HIV transmission. This article will address a range of questions concerning HIV-related depression. Why is depression so common in people with HIV? Is it seen more frequently in those with HIV disease than in uninfected individuals? If so, why? And if depression is so common, why is it typically overlooked by HIV clinicians? Finally, is depression treated differently in people with HIV, and what specific types of therapy or medications are most useful?
Anti-HIV Agents↗