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George Zubal

Publications and source records attributed to George Zubal.

4 recordsLinked to original sources
PubMed2004

Optimizing Compton camera geometries.

Compton cameras promise to improve the characteristics of nuclear medicine imaging, wherein mechanical collimation is replaced with electronic collimation. This leads to huge gains in sensitivity and, consequently, a reduction in the radiation dosage that needs to be administered to the patient. Design modifications that improve the sensitivity invariably compromise resolution. The scope of the current project was to determine an optimal design and configuration of a Compton camera that strikes a balance between these two properties. Transport of the photon flux from the source to the detectors was simulated with the camera geometry serving as the parameter to be optimized. Two variations of the Boltzmann photon transport equation, with and without photon polarization, were employed to model the flux. Doppler broadening of the energy spectra was also included. The simulation was done in a Monte Carlo framework using GEANT4. Two clinically relevant energies, 140 keV and 511 keV, corresponding to 99mTc and 18F were simulated. The gain in the sensitivity for the Compton camera over the conventional camera was 100 fold. Neither Doppler broadening nor polarization had any significant effect on the sensitivity of the camera. However, the spatial resolution of the camera was affected by these processes. Doppler broadening had a deleterious effect on the spatial resolution, but polarization improved the resolution when accounted for in the reconstruction algorithm.

Air↗
PubMed2003

Automated kinetic analysis of FDG uptake in living rat brain slices from dynamic positron autoradiography.

Changes in regional cerebral glucose metabolism were investigated for varying levels of tissue oxygenation using a dynamic positron autoradiography technique. While incubating fresh rat brain slices with [18F]FDG in an oxygenated solution, serial images of the tissue slices were obtained over a time period of up to 300 min and archived onto over 20 phosphorous imaging plate exposures. In order to properly create time activity curves of the uptake levels, images of the individual tissue samples were automatically located, digitally extracted, and registered with the later images of the same tissue samples. After applying image processing techniques for aligning tissue sample images, time activity curves were extracted for individual substructures in the rat brain and quantitative results were reported using Patlak plots. Since the levels of oxygenation can be controlled for these experiments, [18F]FDG uptakes can be reported representing states of hypoxia, pseudoischemia, and reoxygenation. The image processing techniques developed for this application have enabled more experiments and tissue samples to be acquired and analyzed than would otherwise be possible using manual ROI techniques. The objective spatial registration of tissue samples and automated extraction of data has increased the analysis accuracy and decreased the operator error associated with the interactive handling of the image data. This supports improved kinetic modeling of FDG uptake in animal studies, and can be used for more accurate dosimetry calculations in humans.

Animals↗