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Geraldine P Mineau

Publications and source records attributed to Geraldine P Mineau.

7 recordsLinked to original sources
PubMed2006

Preeclampsia and subsequent risk of cancer in Utah.

OBJECTIVE: The purpose of this study was to determine if preeclampsia is associated with a reduced risk of cancer later in life. STUDY DESIGN: We performed a cohort study where women with preeclampsia over the interval 1947 to 1999 were identified from the Utah Population Database. Preeclamptics (n = 17,432) were matched 1:3 with nonpreeclamptics (n = 52,296) on maternal age and birth year. Pregnancy, demographic, and cancer information was extracted from subjects and their offspring in linked datasets. Relative risk and hazard ratios were calculated. RESULTS: In a matched analysis using univariable random-effects Poisson regression, preeclampsia was protective against the development of cancer later in life (RR 0.91, 95% CI 0.84-0.99 with P = .027). In a multivariable clustered Cox regression model with the end point of cancer later in life, preeclampsia was associated with a lower risk of cancer (HR 0.92, 95% CI 0.85-0.99 with P = .039). These findings were supported by stratified and competing risk analyses. CONCLUSION: Women whose pregnancies were affected by preeclampsia have a decreased risk of developing cancer.

Adult↗
PubMed2004

Familial aggregation of juvenile idiopathic arthritis.

OBJECTIVE: To estimate the degree of familial aggregation of juvenile idiopathic arthritis (JIA), determine whether the aggregation of JIA and the aggregation of type 1 diabetes mellitus (type 1 DM) overlap, and identify multiplex JIA pedigrees. METHODS: Records of individuals with JIA or type 1 DM were probabilistically linked with records in the Utah Population Database (UPDB), a large computerized family history database. For each case of JIA or type 1 DM, 10 matched controls or 5 matched controls, respectively, were selected. All familial relationships among cases of JIA or type 1 DM were established. A familial risk score was calculated for each subject. For various levels of familial exposure to JIA or type 1 DM, one's risk (odds ratio [OR]) of developing JIA or type 1 DM was established (cases compared with controls). Recurrence risks for JIA were computed for relatives of JIA cases compared with relatives of controls. Extended JIA families were identified from a list of common ancestors. RESULTS: Records of a total of 443 patients were linked with the UPDB. Of these, 381 (86.0%) met criteria for JIA. An increased risk for JIA was observed among relatives of probands with JIA. The prevalence of type 1 DM among JIA cases was higher than the US prevalence of type 1 DM (P < 0.003). The recurrence risk for JIA was significantly elevated among first-degree relatives of cases with JIA (OR 30.4). The overall prevalence of JIA was 28/100,000. Four extended JIA pedigrees were identified. CONCLUSION: There is familial aggregation of JIA in the Intermountain West region of the US. We have demonstrated that multiplex JIA pedigrees can be identified using a genealogic database.

Adolescent↗
PubMed2004

Twinning and the incidence of breast and gynecological cancers (United States).

Increasing epidemiological and experimental evidence indicates that the carcinogenic pathway in the breast and female reproductive organs is driven, at least in part, by factors associated with reproduction. We conducted a retrospective cohort study, comparing the risk of ovarian, breast, endometrial, and cervical cancers among women who had records of at least one twin pregnancy, compared with women who had given birth to only single children. Subjects were selected from the Utah Population Database, which consists of multiple linked datasets including genealogy, births and deaths and cancer registries. We used Poisson regression to calculate relative risks, adjusted for the number of pregnancies and the age of the mother at the birth of first and last children, with singleton mothers as the reference group in each case. The risks of breast and ovarian cancers did not differ between mothers of twins and mothers of single children. The risk of endometrial cancer was slightly lower in mothers of twins than in mothers of singleton children (RR = 0.90, 95% CI 0.67-1.21). Conversely the risk of cervical cancer was higher among twin mothers (RR = 1.78, 95% CI 0.88-3.52). This latter finding supports previous data suggesting that reproductive hormones act as cofactors in the etiology of cervical cancer.

Adolescent↗
PubMed2003

Biomedical databases: protecting privacy and promoting research.

When combined with medical information, large electronic databases of information that identify individuals provide superlative resources for genetic, epidemiology and other biomedical research. Such research resources increasingly need to balance the protection of privacy and confidentiality with the promotion of research. Models that do not allow the use of such individual-identifying information constrain research; models that involve commercial interests raise concerns about what type of access is acceptable. Researchers, individuals representing the public interest and those developing regulatory guidelines must be involved in an ongoing dialogue to identify practical models.

Computer Security↗
PubMed2002

Historical trends of survival among widows and widowers.

One of the most consistent findings in social demography is that recently widowed individuals, male or female, have higher rates of mortality than comparable married persons. These results are based generally on contemporary studies in developed nations where life expectancy is high. Because of data limitations, there are few studies available to determine whether these findings also occur when mortality rates were higher. This study uses the Utah Population Database that was developed from extensive family genealogies and now linked to Utah death certificates. These data make it possible to employ life course analysis of four marriage cohorts extending from 1860 through 1904 with mortality follow-up to 1990. This approach is used to compare mortality risks of widowed males and females relative to comparable married individuals. Covariates included in the study are remarriage, as well as religion and number of children ever born; these are all hypothesized to have protective effects on mortality risks for widowed men and women. Analysis of these data indicates that there are significant differences in the mortality risk for widowed men and women, and it is widowed men who have an excess risk of dying in every cohort and nearly every age. A consistent pattern of excess mortality in the comparison of married and widowed women was not observed. There are significant female and male differences in the effect of religion which was treated as a proxy for life style and social support: however, remarriage as a proxy for social support has similar protective effects on the surviving spouse.

Adult↗
PubMedDate not supplied

Fertility and post-reproductive longevity.

We examine the effects of reproduction on longevity among mothers and fathers after age 60. This study is motivated by evolutionary theories of aging and theories predicting social benefits and costs of children to older parents. We use the Utah Population Database, that includes a large genealogical database from the Utah Family History Library. Cox proportional hazard models based on 13,987 couples married between 1860-1899 indicate that women with fewer children as well as those bearing children late in life live longer post-reproductive lives. As the burdens of motherhood increase, the relative gains in longevity of late fertile women increase compared to their non-late fertile counterparts. Husbands' longevity is less sensitive to reproductive history, although husbands have effects that are similar to those of their wives during the latter marriage cohort. We find some support for predictions based on evolutionary principles, but we also find evidence that implicates a role for shared marital environments.

Age Factors↗