Biomedical subjects

Gerard J Connors

Publications and source records attributed to Gerard J Connors.

11 recordsLinked to original sources

PubMed2006

Ethnicity and gamma-glutamyltransferase in men and women with alcohol use disorders.

AIMS: This study evaluated the associations of gender and ethnicity with GGT in a large sample of patients with DSM-IV alcohol abuse or dependence, as well as modification of alcohol's effects on GGT by gender and ethnicity. METHODS: Subjects included 1691 African American, Mexican American, and non-Hispanic white individuals with DSM-IV alcohol dependence or abuse who participated in an alcoholism treatment trial. Detailed information on alcohol use was collected and GGT measured at baseline and at 3, 9, and 15 months post-baseline. RESULTS: Changes in GGT occurring with changes in alcohol consumption were similar regardless of ethnicity. Although alcohol-associated changes were similar in these ethnic groups, African Americans had the highest average GGT at any given level of alcohol use. This ethnic pattern held for both sexes, with females having lower levels within each ethnic group. Drinking frequency had a slightly decreased association with GGT in females relative to males, but this effect was clinically unimportant. CONCLUSIONS: Gender and ethnic-specific cutoffs may be useful when screening for chronic heavy drinking, but the absolute increase in GGT occurring with relapse will be similar regardless of gender or ethnicity.

Adolescent↗

PubMed2006

Relapse-onset factors in Project MATCH: the Relapse Questionnaire.

Previously, items on the relapse-onset section of the Relapse Questionnaire have been grouped together based on face validity. In the present article, an empirical scoring method for this measure is derived through a factor analysis of Project MATCH data. Three factors replicate the factor solutions of other measures of alcohol relapse onset and relapse risk. The three factors found in this study include the following: Negative Affect/Family Influences, Craving/Cued, and Social Pressure. This study also replicates earlier findings that social pressure relapses are most likely to repeat, and that negative affect relapses are more severe. Earlier studies typing relapses have hypothesized that this may be one method to detect treatment effects that might otherwise be missed if relapses are not differentiated and only generic measures (such as time to first drink) are used. This hypothesis is tested in the present article, and Motivational Enhancement Therapy is revealed to offer protection against social pressure relapses that is less than those offered by Cognitive-Behavioral Coping Skills Therapy or Twelve-Step Facilitation Therapy.

Adult↗

PubMed2006

Course of functioning 1 year following admission for treatment of alcohol use disorders.

Research on alcohol treatment outcomes has the potential to advance knowledge about how treatment combines with other variables to influence post treatment course of functioning. The purpose of this study was to replicate and extend [Connors, G. J., Maisto, S. A., & Zywiak, W. H. (1996). Understanding relapse in the broader context of post-treatment functioning. Addiction, 91 (Suppl.), S173-S189] test of a multivariate model of course by testing the model's fit to data from a larger sample and the use of stronger statistical methods. The participants were 400 men and women presenting for alcohol treatment in two cities in the US. These individuals completed a pretreatment (baseline) assessment battery at treatment initiation and then completed follow-up assessments bimonthly for a period of 1 year. The model included pretreatment, treatment (months 1-6), and post-baseline (months 1-6) factors to predict alcohol use (percent days abstinent, drinks/drinking day, and total number drinks/month, all for months 7-12). The application of structural equation modeling methods revealed that the model fit the data adequately for all three dependent variables, with the major significant findings of direct effects of treatment setting, coping skills, and the mediation of treatment effects through coping skills. Overall, the data replicated several findings from the Connors et al.'s study and point to the importance of investigating the mechanisms underlying treatment effects and the mediation of treatment effects by coping skills in future research.

Adaptation, Psychological↗

PubMed2006

Alcohol relapse repetition, gender, and predictive validity.

Earlier exploratory work on a scoring algorithm for the Reasons for Drinking Questionnaire. Exploratory findings from the Reasons for Drinking Questionnaire presented a number of interesting findings, but were limited by a fairly low consistency in type of relapse between the first relapse and the second relapse (63%). This scoring algorithm objectively classifies alcohol relapses into one of three types (negative affect, social pressure, or craving/cued). While examining gender differences in the type of first relapse, evidence indicating that relapses were more consistent for men (81%) than for women (44%) was uncovered. For initial posttreatment relapses, women were more likely to have negative affect relapses, and men were more likely to have social pressure relapses. For men, negative affect relapses were predicted by the Beck Depression Inventory score. For women, negative affect relapses were predicted by the Alcohol Dependence Scale score, and craving/cued relapses were predicted by situational craving.

Alcoholism↗

PubMed2005

Relapse in the addictive behaviors: integration and future directions.

This paper identifies the major consistencies in substantive and methodological findings across the review papers in this special issue on relapse in the addictive behaviors. The papers were consistent in suggesting that there have been major methodological advances which have helped to move the field forward. Furthermore, the papers show the need for taking a biopsychosocial approach to the study of relapse and the major difficulty across addictive behaviors in creating an acceptable operational definition of relapse. Suggestions for future research directions that follow from the papers include deriving and evaluating relapse definitions, systematically developing and testing models and theories of relapse, and understanding and narrowing the relapse research-clinical practice gap.

Alcoholism↗

PubMed2003

Exploratory findings from the Reasons for Drinking Questionnaire.

Marlatt and Gordon's (1985) relapse prevention therapy has received widespread interest and application. The categorization of relapse precipitants was one of the original central features of this model. In more recent iterations of this therapy, increasing emphasis has been placed on coping strategies. In the present article, exploratory findings from a prospective naturalistic alcohol treatment study employing the Reasons for Drinking Questionnaire are reported. A relapse precipitants scoring algorithm is presented allowing relapses to be categorized as either negative affect relapses, social pressure relapses, or craving/cued relapses. Exploratory findings suggest that social pressure relapses are more likely to repeat, and that negative affect and craving/cued relapses are more severe. Perhaps most interestingly, craving/cued relapses appear to subside during the first 6 months following treatment initiation, but subsequent risk for this type of relapse returns if the client has relapsed. However, these findings are still early in a continuing exploration of these issues in relapse prevention.

Adult↗

PubMed2003

Drinking reports from collateral individuals.

BACKGROUND AND AIMS: Subject self-reports are the primary source of research and clinical data on drinking behavior. In this report, we review and summarize the current literature on the reliability and accuracy of alcohol abusers' self-reports of alcohol consumption and related behaviors in relation to similar reports provided by collateral informants. CONCLUSIONS: Recent research supports the assertion that subjects provide accurate reports about their drinking and associated consequences. When discrepancies have been observed between reports provided by subjects and collaterals, the subjects' data in almost all cases have painted a picture of poorer functioning. The greatest degree of agreement between subjects and collaterals is likely when collaterals are in frequent contact with the subject, are spouse/partners and are confident about the reports they are providing.

Adolescent↗

PubMed2003

Assessing drinking outcomes in alcohol treatment efficacy studies: selecting a yardstick of success.

BACKGROUND: Although the number of alcohol treatment efficacy trials has mushroomed, there is no consensus on how best to measure outcomes. To advance the goal of establishing cross-trial consistency in measuring outcomes in clinical efficacy studies, the National Institute on Alcohol Abuse and Alcoholism convened a panel of experts and charged them with exploring, debating, and, ultimately, selecting a "sentinel" or "optimal" outcome measure to be used in future alcohol treatment studies. The goal of this article, one in a series of several presented at the National Institute on Alcohol Abuse and Alcoholism conference, is to discuss (1) the rationale underlying selection of an optimal outcome measure, (2) the necessary characteristics of an optimal outcome measure, (3) the utility of selecting an optimal measure, and (4) which drinking assessment methods could be used to collect data to portray the optimal outcome measure. METHODS: At a minimum, the criteria for an "optimal" measure include that it be psychometrically sound. In addition, it should have considerable currency in the field, thereby increasing its prospects for adoption. The measure should also be consistent with the concepts of greatest interest and relevance to the field (e.g., directly reflect the fundamental goal of alcohol treatment). In light of these highly desired features, percent of days heavy drinking was chosen at the conference as a practical and relevant measure of alcohol treatment outcome. CONCLUSIONS: Percent of days heavy drinking should be the optimal measure of alcohol treatment outcome. Currently, daily drinking estimation methods are the most useful for gathering data that can reflect the optimal measure. In addition, data gathered by daily drinking estimation methods can be used to study a variety of other outcome variables of interest to clinical researchers.

Alcohol Drinking↗

PubMed2002

Preparing clients for alcoholism treatment: effects on treatment participation and outcomes.

In this study, 126 clients (87 men, 39 women) entering outpatient alcoholism treatment were assigned randomly to 1 of 3 preparatory conditions: a role induction (RI) session, a motivational interview (MI) session, or a no-preparatory session control group (CG). Clients assigned to the MI preparatory condition attended more treatment sessions and had fewer heavy drinking days during and 12 months after treatment relative to CG clients. Clients assigned to MI, relative to CG clients, also had more abstinent days during treatment and during the first 3 months posttreatment, although this difference was not maintained through the remainder of the 12-month follow-up period. Clients assigned to the RI condition showed no significant advantage over those in the CG condition.

Adult↗

PubMed2002

Relapse prevention and maintaining abstinence in older adults with alcohol-use disorders.

Although older adults are sometimes believed to have the lowest rates of alcohol abuse as an age cohort, the prevalence of alcohol use and abuse in this group is clearly underestimated. The under-diagnosis of alcohol abuse is due, in part, to the facts that the effects of alcohol use among older adults tend to be less clearly visible than among other age groups and that older adults are less likely to seek treatment than younger age groups. An additional challenge to diagnosis may be a lack of previous alcohol abuse by the patient, as approximately one-third of older adults with alcohol-use problems first develop their drinking problem after the age of 60 years. With a demographic shift that is expected to increase the number of older adults with alcohol problems, the awareness and understanding of this problem becomes increasingly important. Under-diagnosis of problem drinking in older adults is particularly unfortunate because the risks associated with alcohol abuse and relapse for the elderly are significant. Relapse, or the return to drinking following abstinence, may follow situations that are of particularly high risk for older adults. These include situations related to anxiety, interpersonal conflict, depression, loneliness, loss or social isolation. By helping patients to monitor these high-risk situations, to identify strategies that have been successful in promoting abstinence in the past, and to become engaged in treatment, relapse may be avoided and abstinence maintained. Treatments such as cognitive-behavioural therapy, group and family therapies and self-help groups are just as effective for older adults as they are for other age groups. In fact, group and family therapies and self-help groups may be of particular benefit to older adults because of the emphasis on social support. Medicinal adjuncts are also equally effective in the elderly, but strict compliance and careful monitoring of adverse effects are especially important in patients who take multiple medications. Because of their benign adverse effect profiles, naltrexone and acamprosate are particularly good pharmacological agents for relapse prevention in older adults.

Aged↗

PubMedDate not supplied

Exploration of the relationship between drinking intensity and quality of life.

This work explored the association between quality of life and drinking intensity in the Project MATCH sample. Tobit regression models were evaluated to assess the relationship between quality of life indicators (eg, measures of depression, adverse consequences, and others) and drinks per drinking day (DDD), and to assess modification or confounding of DDD by subject characteristics and treatment type. Each quality of life indicator improved with decreased DDD. Gender and ethnicity modified the DDD effect for some outcomes, with DDD exerting a greater influence on quality of life in women and non-Hispanic whites.

Adult↗