Tuberculosis diagnostic tests: sensitivity, specificity, and comparing apples with apples.
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Antigens, Bacterial↗
Biomedical subjects
Gian Sberna
Publications and source records attributed to Gian Sberna.
Physaloside A, an acylated sucrose ester from Physalis viscosa.
Chemical investigations of the crude MeOH extract of Physalis viscosa led to the identification of the novel acylated sucrose ester physaloside A (1). The structure of 1 was determined by 2D NMR analysis, and the absolute configuration was determined by chemical degradation and comparison with authentic standards.
Australia↗
Cerylimycins [corrected] A and B: antibacterial triterpenes from the new species Tricholoma sp. AU1.
To new triterpenes, trichomycins A (1) and B (2), were purified from the new species Tricholoma sp. AU1 by activity-guided fractionation following their antibacterial activity. The two compounds were found to have a hitherto unreported triterpenoid skeleton. The structures and relative stereochemistry of 1 and 2 were determined through extensive 2D NMR spectroscopy, while the inhibitory activity of 1 and 2 against two Gram-positive and two Gram-negative bacteria and a mammalian cell line was determined.
Anti-Bacterial Agents↗
Globoidnan A: a lignan from Eucalyptus globoidea inhibits HIV integrase.
An HTS campaign aimed at the identification of inhibitors of HIV integrase showed that the methanol extract from the buds of a Eucalyptus globoidea was active. Bioassay guided fractionation of this extract resulted in the purification and structural elucidation of the lignan, globoidnan A (1) as the only compound in the extract responsible for the inhibition of HIV integrase. The compound was found to inhibit the combined 3' processing and strand transfer activity of HIV integrase with an IC50=0.64 microM.
Eucalyptus↗
A diketopiperazine dimer from a marine-derived isolate of Aspergillus niger.
The new diketopiperazine dimer 1, as well as the known compounds TMC-256A1 (2), TMC-256C1 (3), and demethylkotanin (4), were isolated from a culture of Aspergillus niger. The gross structure of 1 was determined by 2D NMR studies and comparison with literature data, and the absolute stereochemistry was elucidated by chiral HPLC analysis of the hydrolysis products.
Aspergillus niger↗