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Biomedical subjects

Gianpaolo Guzzi

Publications and source records attributed to Gianpaolo Guzzi.

12 recordsLinked to original sources
PubMed2006

Dental amalgam and mercury levels in autopsy tissues: food for thought.

Eighteen cadavers from routine autopsy casework were subject to a study of tissue levels of total mercury in brain, thyroid, and kidney samples by atomic absorption. On these same cadavers, all dental amalgam fillings (the most important source of inorganic mercury exposure in the general population, according to the World Health Organization (WHO) were charted. Total mercury levels were significantly higher in subjects with a greater number of occlusal amalgam surfaces (>12) compared with those with fewer occlusal amalgams (0-3) in all types of tissue (all P < or = 0.04). Mercury levels were significantly higher in brain tissues compared with thyroid and kidney tissues in subjects with more than 12 occlusal amalgam fillings (all P < or = 0.01) but not in subjects with 3 or less occlusal amalgams (all P > or = 0.07).

Brain Chemistry↗
PubMed2004

Recovery from mercury-induced burning mouth syndrome due to mercury allergy.

We report a case in which burning mouth syndrome (BMS) was associated with a strong allergy to mercury. The aim of this case history is to strengthen knowledge of the relationship among allergy to mercury, systemic allergic contact dermatitis, and hypersensitivity of the oral mucosa. We performed series of standard and dental patch tests for screening for contact allergy to dental materials, in accordance with International Contact Dermatitis Research Group guidelines. Positive extreme allergic reactions to mercury (+++) and amalgam (++) were seen at the patch site and caused a flare-up of the systemic erythematous reaction. Full recovery from BMS and complete remission of systemic dermatitis were achieved after the mercury tooth filling was removed. Mercury is thought to be an allergen implicated in BMS as well as in the systemic reactivation of allergic contact dermatitis. Patch testing with dental series seems to have greater sensitivity and relevance in BMS patients.

Aged↗