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Gilberto Alonso

Publications and source records attributed to Gilberto Alonso.

3 recordsLinked to original sources
PubMed2006

[Reference values for thyroid 24 hours 123I uptake].

To establish references for thyroid 24 h 123I uptake value (TUV), we reviewed 475 patients who had free T4 and TSH dosages, and TUV measured 24h after the administration of 123I. The patients were separated in 3 groups: hyperthyroid, euthyroid and hypothyroid, according to thyroid hormone results. The mean and standard deviation (SD) of the TUVs were calculated for each group. We used the unpaired T test to compare the means and ROC curves to evaluate the best TUV to separate the groups. The mean and SD of TUVs for the groups were: hyperthyroid (36.5% +/- 16.5%), euthyroid (14.4% +/- 5.48%) and hypothyroid (13.7% +/- 7.5%). The unpaired T test showed statistically significant difference between hyperthyroid and euthyroid groups (p < 0.01). There was no significative difference between hypothyroid and euthyroid groups (p = 0.55). The 23% TUV has the best sensitivity (80%)/specificity (93%) ratio to separate hyperthyroid from euthyroid groups. There was not a good TUV to separate euthyroid form hypothyroid groups. In conclusion, it can be established 23% as the optimal superior limit for the normal uptake values. However, it was not possible to establish a suitable inferior limit, due to the expressive overlay of TUVs of hypothyroid and euthyroid groups.

Adolescent↗
PubMed2006

[The relation between serum levels of calcium and PTH and the positivity of parathyroid scintigraphy with sestamibi--analysis of 194 patients].

To correlate PTH and calcium serum levels with the percentages of positive results on the parathyroid scintigraphy, we retrospectively analyzed 194 patients who performed parathyroid scintigraphy. The distribution of the parathyroid scintigraphy results was visually analyzed in a scatter plot, being calcium (Y axis) and PTH (X axis) serum levels the axes. Six groups of patients were defined: 1) calcium > or = 12 mg/dL; 2) 11 mg/dL calcium < 12 mg/dL; 3) 9.9 mg/dL < or = calcium < 11 mg/dL with PTH > 120 pg/mL; 4) 9.9 mg/dL < or = calcium < 11 mg/dL with 65 pg/mL < PTH < or = 120 pg/mL; 5) 9.9 mg/dL < or = calcium < 11 mg/dL with PTH < or = 65 pg/mL; and 6) calcium < 9.9 mg/dL. The percentage of positive scintigraphy in these groups were respectively: 10/10 (100%), 18/29 (62%), 7/9 (78%), 18/45 (40%), 2/21 (10%) and 1/80 (1%). We conclude that in patients with suspected primary hyperparathyroidism, parathyroid scintigraphies performed before surgery on those with calcium level above 11 mg/dL are frequently positive. In patients with calcium levels between 9.9 mg/dL and 11 mg/dL the pertinence of performing the scintigraphy will depend on the PTH levels, and it will be high for patients with PTH serum level above 120 pg/mL and very low for patients with PTH level below 65 pg/mL. Patients with calcium level below 9.9 mg/dL rarely present positive results on parathyroid scintigraphies.

Adult↗