Biomedical subjects

Giseon Heo

Publications and source records attributed to Giseon Heo.

21 records · Page 2Linked to original sources

PubMed2002

Randomized controlled trial of botulinum toxin A for chronic myogenous orofacial pain.

The purpose of this study was to determine whether botulinum toxin A (BTX-A) was efficacious for the treatment of chronic moderate to severe jaw muscle pain in females. This was a randomized double-blind, placebo-controlled crossover trial of BTX-A. Twenty five units injected into each temporalis muscle and 50 U injected into each masseter muscle using three sites per muscle with 0.2 cm(3) per site. Data were collected at baseline, 8, 16, 24 weeks, with crossover occurring at 16 weeks. Primary outcome variables were pain intensity and unpleasantness, measured by horizontal visual analog scale (VAS). Secondary outcome variables were maximum interincisal opening without and irrespective of pain, muscle palpation tenderness (12 points), and four general questions. Fifteen female patients were enrolled (18-45 years), but only ten completed the trial. Of those who finished, no statistically significant difference was found in pain intensity (P=0.10), unpleasantness (P=0.40), palpation muscle tenderness (P=0.91), or the three general questions (P=0.64, P=0.66, P=0.67). Statistical significance was achieved for maximum opening without pain (P=0.02) and irrespective of pain (P=0.005) with the BTX-A arm having a relative decreased opening. No statistically significant difference was observed in any outcome measures except maximum opening, which showed BTX-A patient opening less wide than placebo. The results do not support the use of BTX-A in the treatment of moderate to severe jaw muscle pain in this patient population.

Adolescent↗

PubMed2002

The accuracy of 4 panoramic units in the projection of mesiodistal tooth angulations.

The purpose of this study was to compare the mesiodistal tooth angulations determined with a typodont/skull testing device with the images of mesiodistal tooth angulations from 4 contemporary panoramic units (OP 100, Cranex 3+, Orthophos, PM 2002 EC). A typodont testing device was constructed, and the true mesiodistal tooth angulations relative to an orthodontic archwire were determined with a 3-dimensional coordinate-measuring machine and custom-designed software. A human skull served as the matrix into which the typodont was fixed for imaging. The skull was repeatedly imaged and repositioned 5 times for each panoramic unit. The images were scanned and digitized with custom software to determine the image mesiodistal angulations. Results revealed that the majority of image angles from the 4 panoramic units were statistically significantly different from the true angle measurements. However, definite trends were noted among the panoramic units. For the maxillary teeth, the images projected the anterior roots more mesially and the posterior roots more distally, creating the appearance of exaggerated root divergence between the canine and the first premolar. For the mandibular teeth, the images projected almost all roots more mesially than they really were, with the canine and the first premolar the most severely affected. The largest angular difference for adjacent teeth occurred between the mandibular lateral incisor and the canine, with relative root parallelism projected as root convergence. It was concluded that the clinical assessment of mesiodistal tooth angulation with panoramic radiography should be approached with extreme caution and with an understanding of the inherent image distortions.

Analysis of Variance↗

PubMed2002

Orthodontic treatment outcome in a First Nations population in Alberta, Canada: a comparative study.

The primary objective of this study was to determine whether there was a significant difference in the degree of improvement after orthodontic treatment between a sample of First Nations orthodontic patients and a control sample of non-First Nations orthodontic patients. The secondary objective was to determine whether there was a difference in the severity of malocclusions being treated in a sample of the First Nations patients compared with a control sample of the non-First Nations patients. Several factors that might affect treatment outcome, such as missed appointments, treatment duration, oral hygiene, extractions, dental classification, and geographic location, were also studied. A sample of 60 First Nations patients and a control group of 60 non-First Nations patients between the 11 and 18 years of age who had been treated with full fixed orthodontic appliances were evaluated. The weighted peer assessment rating (PAR) index was applied to pretreatment and posttreatment study models to address the study's main objectives. The results showed that the First Nations group had greater PAR scores pretreatment than did the controls, and their weighted PAR scores improved more with treatment. Posttreatment PAR scores were similar between the 2 groups. In addition to First Nations status, only extractions and geographic location affected PAR improvement scores.

Adolescent↗