Biomedical subjects

Glen Palmer

Publications and source records attributed to Glen Palmer.

4 recordsLinked to original sources

PubMed2005

Immunotherapeutic approaches to enhance protective immunity against Candida vaginitis.

Protective host defense mechanisms against vaginal Candida infections are poorly understood. While cell-mediated immunity (CMI) is the predominant host-defense mechanism against most mucosal Candida infections, no protective role for systemic or local Candida-specific CMI or antibodies has been identified against vaginal candidiasis. Rather, evidence exists for immunoregulation in vaginal tissue, which may inhibit a more profound protective Th1-type response. This study evaluated immunotherapy and gene therapy approaches in the murine model to potentially overcome immunoregulation and promote enhanced protection against vaginal candidiasis. In the first set of studies, the intravaginal and systemic administration of Thl-type cytokines and anti-IL-10 and anti-TGF-beta antibodies failed to enhance protection against a vaginal Candida infection. In a second set of studies, the novel intravaginal administration of Adenoviruses encoding Th1-type cytokines (IFN-gamma and IL-12) and the chemokine, MCP-1, showed substantial, but transient (24 h) expression of each in vaginal tissue and draining lymph nodes, even with a second administration. Unfortunately, treatment with these Adenoviral vectors did not enhance protection against experimental vaginitis. Construction of a new vector encoding IFN-gamma with a stronger promoter produced substantial IFN-gamma in vitro, but lower amounts in vivo and no extended expression. Taken together, while gene therapy can be used to induce cytokine expression in vaginal tissue, there appear to be strong regulatory mechanisms that additional manipulations or alternative approaches will have to overcome if protection against vaginitis is to be enhanced.

Animals↗

PubMed2004

Health professional student attitudes towards people with disability.

OBJECTIVE: To investigate health professional student attitudes toward people with disability. It was hypothesized that attitude and comfort would differ by discipline. Further, it was hypothesized that factors such as gender and background in disability would influence these attitudes and their ease in dealing with difficult encounters in rehabilitation. DESIGN: A cross-sectional survey design. SETTING: University of South Dakota (USD) PARTICIPANTS: Three hundred and thirty-eight students were surveyed. MAIN OUTCOME MEASURES: (a) Attitude Toward Disabled Persons (ATDP) scale; (b) Scale of Attitudes Toward Disabled Persons (SADP); (c) Rehabilitation Situations Inventory (RSI). RESULTS: There were differences among student groups on the attitude scales and factor scores. All students' attitudes were less positive than SADP norms and nursing students held the least positive opinions. There were no attitudinal differences by gender. Those with a background in disability held more positive attitudes. Years of experience and hours per week employed predicted comfort with challenging rehabilitation situations. Inconsiderate treatment by staff, inappropriate sexual overtures and aggressive behaviour by patients were stated to be most challenging. CONCLUSION: Health professional students hold less positive attitudes than SADP norms. Nursing undergraduate students were at greater risk of holding negative attitudes. Work experience was important for comfort with challenging rehabilitation situations. Specific educational experiences are needed to promote more positive attitudes.

Adult↗

PubMed2002

Morphometric and neuropsychologic studies in children with arachnoid cysts.

Temporal lobe arachnoid cysts are common findings during brain imaging. Debate exists regarding whether they result from temporal lobe agenesis or are a malformation of the arachnoid matter. We measured temporal lobe volumes in five children with left middle cranial fossa arachnoid cysts using morphometric analysis of magnetic resonance imaging scans. Three patients had neuropsychologic testing, and two patients had positron emission tomography scanning. All patients had significantly smaller left temporal lobes compared with the right side. On neuropsychologic testing two patients had cognitive deficits suggestive of left temporal lobe dysfunction. Temporal lobes adjacent to arachnoid cysts are smaller and less metabolically active when compared with the temporal regions on the opposite side. Patients with middle cranial fossa arachnoid cysts should undergo careful assessment of temporal lobe structure and function before any therapeutic intervention.

Adolescent↗

PubMed2002

Medical students' attitudes toward persons with disability: a comparative study.

OBJECTIVES: To investigate first-year medical students' attitudes toward persons with disability and to examine whether gender and a background in disability determine attitudes toward persons with disability. DESIGN: A cross-sectional survey. SETTING: University settings in the United States and Canada. PARTICIPANTS: Ninety first-year medical students (US, n=46; Canada, n=44) were surveyed. INTERVENTION: Medical students given 3 surveys. MAIN OUTCOME MEASURES: Attitude Toward Disabled Persons (ATDP) Scale, Scale of Attitudes Toward Disabled Persons (SADP), and Rehabilitation Situations Inventory (RSI). RESULTS: There were no differences between the medical student groups from the United States and Canada. Compared with norms, medical students overall have more positive attitudes on the ATDP. Their attitudes were less positive on the SADP and on its optimism-human rights subscale. On the RSI, they were less comfortable with sexual situations and depression. Male medical students held poorer attitudes as scored than female medical students. Those with a background in disability were more comfortable dealing with challenging rehabilitation situations. Comfort with challenging rehabilitation situations showed significant differences across levels of experience but not gender. The more positive medical students' attitudes are toward persons with disability, the more likely they are to be comfortable with challenging rehabilitation situations. CONCLUSION: First-year medical students from the United States and Canada held similar attitudes and had less positive attitudes than SADP norms. Gender and background in disability influenced attitudes. Male medical students were more likely to hold negative attitudes. Specific educational experiences need to promote more positive attitudes.

Adult↗