Biomedical subjects

Glenn Harris

Publications and source records attributed to Glenn Harris.

3 recordsLinked to original sources

PubMed2005

Tools and strategies for physiological genomics: the Rat Genome Database.

The broad goal of physiological genomics research is to link genes to their functions using appropriate experimental and computational techniques. Modern genomics experiments enable the generation of vast quantities of data, and interpretation of this data requires the integration of information derived from many diverse sources. Computational biology and bioinformatics offer the ability to manage and channel this information torrent. The Rat Genome Database (RGD; http://rgd.mcw.edu) has developed computational tools and strategies specifically supporting the goal of linking genes to their functional roles in rat and, using comparative genomics, to human and mouse. We present an overview of the database with a focus on these unique computational tools and describe strategies for the use of these resources in the area of physiological genomics.

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PubMed2005

The Rat Genome Database (RGD): developments towards a phenome database.

The Rat Genome Database (RGD) (http://rgd.mcw.edu) aims to meet the needs of its community by providing genetic and genomic infrastructure while also annotating the strengths of rat research: biochemistry, nutrition, pharmacology and physiology. Here, we report on RGD's development towards creating a phenome database. Recent developments can be categorized into three groups. (i) Improved data collection and integration to match increased volume and biological scope of research. (ii) Knowledge representation augmented by the implementation of a new ontology and annotation system. (iii) The addition of quantitative trait loci data, from rat, mouse and human to our advanced comparative genomics tools, as well as the creation of new, and enhancement of existing, tools to enable users to efficiently browse and survey research data. The emphasis is on helping researchers find genes responsible for disease through the use of rat models. These improvements, combined with the genomic sequence of the rat, have led to a successful year at RGD with over two million page accesses that represent an over 4-fold increase in a year. Future plans call for increased annotation of biological information on the rat elucidated through its use as a model for human pathobiology. The continued development of toolsets will facilitate integration of these data into the context of rat genomic sequence, as well as allow comparisons of biological and genomic data with the human genomic sequence and of an increasing number of organisms.

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PubMed2004

Comanagement of wildlife corridors: the case for citizen participation in the Algonquin to Adirondack proposal.

The debate between top-down and bottom-up planning has recently re-emerged in environmental management. Many commentators agree on the merits of comanagement, in which affected citizens and professional managers share responsibility for planning. Nevertheless, the manifold advantages of comanagement have not always been fully appreciated in environmental planning. For example, a group representing NGOs and academic institutions recently proposed an ecological corridor linking Algonquin Provincial Park in southern Ontario to the Adirondack Park in northern New York. This corridor, known as A2A, was designed to encourage the migration of wolves and other wildlife between the parks. Much of the land in A2A is private property. A survey of households, randomly scattered throughout the United States portion of the corridor, revealed that affected landowners had little knowledge of the proposal and no contact with its advocates. Many respondents were farmers who utilized land for livelihood. Other landowners enjoyed property for a variety of recreational purposes. Regardless of use, survey participants placed high value on the importance of conserving biological diversity. They also expressed great distrust toward restrictions that might be placed on their activities. In general, respondents felt very unsure about A2A, and they were uncertain about personal involvement in the planning process. Certain landowners indicated a willingness to have their land be included in an ecological corridor, despite not knowing about it before the survey was administered. These results suggest that A2A proponents have little to lose and much to gain by disseminating information locally and by embracing comanagement for further formulation of this plan.

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