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Biomedical subjects

Gregory A Dumanian

Publications and source records attributed to Gregory A Dumanian.

At least 19 recordsLinked to original sources
PubMed2006

Rectourethral fistula associated with two short segment urethral strictures in the anterior and posterior urethra: single-stage reconstruction using buccal mucosa and a radial forearm fasciocutaneous free flap.

INTRODUCTION: We report a novel surgical technique used to repair a rectourethral fistula associated with two short-segment urethral strictures located in the anterior and posterior segments of the urethra in a patient with prior unsuccessful repairs. TECHNICAL CONSIDERATIONS: The anterior urethral stricture was reconstructed with a ventral onlay of buccal mucosa in the exaggerated lithotomy position. In a modified prone position, the rectourethral fistula was repaired using the transrectal transsphincteric (York-Mason) technique and the posterior urethral stricture with a radial forearm fasciocutaneous free flap which was anastomosed to the inferior gluteal artery and vein. The coexistence of a rectourethral fistula and distal urethral stricture requires simultaneous repair, because the urethral pressure from the distal obstruction may compromise fistula closure. Reconstructive efforts should be tailored to minimize disruption of the urethral blood supply in patients with previous pelvic trauma. Rectal and urethral repairs should be separated by well-vascularized tissue to prevent fistula recurrence. CONCLUSIONS: The radial fasciocutaneous flap may offer the reconstructive surgeon another surgical option for complex urethral stricture and rectourethral fistula reconstruction when the local blood supply is in question. Longer follow-up and more cases are needed to further evaluate the continued use of this technique.

Adult↗
PubMed2006

Improved myoelectric prosthesis control accomplished using multiple nerve transfers.

BACKGROUND: The control of shoulder-level disarticulation prostheses is significantly more difficult than that of prostheses for more distal amputations. Amputees have significant difficulties coordinating the separate functions of prosthetic shoulder, elbow, wrist, and hand/hook components. The user must lock one joint at a particular position in space before subsequently moving a different joint. METHODS: A patient with bilateral humeral disarticulations after an electrical injury underwent a novel nerve transfer procedure designed to improve the control of a myoelectric prosthesis. The median, radial, ulnar, and musculocutaneous nerves were transferred to the nerves of segments of the pectoralis major and minor muscles. Those muscles then act as bioamplifiers of peripheral nerve signals when the normal upper extremity nerves are activated by the patient's brain. Therefore, when the patient thinks "flex elbow," the transferred musculocutaneous nerve fires, and a segment of the pectoralis major contracts. An electromyographic signal is then detected transcutaneously and causes the prosthetic elbow to flex. RESULTS: Three of the four nerve transfers were successful. One of the nerve transfers unexpectedly yielded two separate controllable muscle segments. Standardized testing using a "box-and-blocks" apparatus was performed with the patient's previous myoelectric device and the current device after nerve transfers. The patient's performance improved by 246 percent. CONCLUSIONS: Nerve transfers to small muscle segments are capable of creating a novel neural interface for improved control of a myoelectric prosthesis. This is done using standard techniques of nerve and flap surgery, and without any implantable devices.

Arm↗
PubMed2005

Panniculectomy and the separation-of-parts hernia repair: a solution for the large infraumbilical hernia in the obese patient.

BACKGROUND: Infraumbilical hernias in the obese are problematic in terms of achieving adequate exposure and eventual wound healing. Simultaneous panniculectomy with separation-of-parts hernia repair is one approach to this reconstructive issue, but the feasibility of such a combination is untested. METHODS: Twenty-four simultaneous panniculectomy and separation-of-parts hernia repairs performed by the senior surgeon over a 6-year period are presented. Patients were analyzed by preoperative, intraoperative, and postoperative parameters. Complications were grouped into major and minor categories. RESULTS: Average patient body mass index was 39 (range, 29 to 57). Twenty of 24 (83 percent) of the hernias were recurrent on initial presentation. Almost one-half of the cases were contaminated (46 percent), marked by the presence of a preoperative wound (29 percent) or concurrent gastrointestinal procedure (17 percent). In 25 percent of cases, a preexisting laparotomy scar necessitated a vertical reopening of the abdominal skin, raising the stakes for postoperative wound breakdown. Despite these findings, major/minor wound complications (12.5 percent/33 percent) and additional surgery rates (17 percent) were relatively low considering this morbidly obese population. Postoperative wound complications, hernia recurrence, and reoperation rates were significantly increased among those patients whose body mass index exceeded 35(p < 0.05). All hernia recurrences (n = 4) were corrected definitively with a secondary direct repair. Mean follow-up was 10 months (range, 3 to 60 months). CONCLUSION: The separation-of-parts hernia repair in combination with pannus resection can be performed safely in obese patients, with complication rates comparable to those reported in the literature. This combined procedure has become the authors' procedure of choice in these difficult clinical situations.

Abdominal Wall↗
PubMed2005

Preoperative radiation therapy and its effects on outcomes in microsurgical head and neck reconstruction.

OBJECTIVE: Preoperative radiation therapy is considered a significant factor in head and neck reconstruction. STUDY AND DESIGN AND SETTING: In our consecutive series of 114 patients, 44 patients had prior head and neck irradiation. The 2 groups were compared on the basis of age, ischemic time, and flap size and were found not to be statistically different. The average ischemic time for the irradiated group was 94.1 minutes, and the average was 102.8 minutes for the nonirradiated group. The average flap size for the irradiated group was 69.5 cm 2 and was 72.0 cm 2 for the nonirradiated group. RESULTS: Using a single-factor analysis of variance, the 2 groups did not differ statistically. The overall major flap complication rate for both irradiated and nonirradiated groups was approximately 10%. CONCLUSION: Microvascular reconstruction was accomplished in both irradiated and nonirradiated head and neck patients, with a 99% total flap survival rate and a 10% major flap complication rate.

Aged↗
PubMed2005

Indications and rationale for use of vascularized fibula bone flaps in cervical spine arthrodeses.

BACKGROUND: Anterior cervical spine arthrodesis for large defects using autograft or allograft fibula for anterior structural support is a widely accepted procedure. In unique demand situations, a vascularized fibular flap is regarded as an "improvement" to the standard procedure. While a vascularized flap does deliver living tissue to the region, it does so with added potential morbidity and increased technical demand. The indications in the literature for this procedure have not been clearly defined. In this article, the authors review specific high-demand situations where they believe a vascularized flap is indicated. They also review patient outcomes after this procedure. METHODS: Fibular free flaps were used in six patients with failed previous cervical spine arthrodeses. Three of the six patients had preoperative radiation therapy, and one received postoperative radiation treatment. All six patients had tumor and/or osteomyelitis present. RESULTS: One patient died of intraoperative hypotension 3 days after a successful free flap transfer during an elective posterior spine instrumentation procedure. One flap was lost from a venous thrombosis, and the patient was then treated successfully with a second fibular free flap. Clinical and radio-graphic evidence of fusion was obtained at 3 months in the five surviving patients, and neurologic function remained stable or improved. CONCLUSIONS: Analyzing their results and the literature, the authors propose that fibular free flaps are indeed a useful adjunct in difficult cervical spine stabilization procedures. Indications for this flap include combinations of the following situations: failed prior attempts at fusion, anterior cervical arthrodeses of three or more vertebral levels, osteomyelitis of the spine, and tumor cases when the spine has been or will be radiated.

Aged↗
PubMed2004

Early results with use of gracilis muscle flap coverage of infected groin wounds after vascular surgery.

INTRODUCTION: Management of a nonhealing femoral wound after vascular surgery can pose a challenging problem, particularly when there is prosthetic material involved. We prefer to use pedicled gracilis muscle flaps (PGMFs) to cover problematic groin wounds when more conventional management is not possible. METHODS: We describe the technique for using PGMFs to provide groin coverage, report a summary of our short-term and long-term results, and describe why we prefer this reconstructive technique. RESULTS: Twenty PGMFs were placed in 18 patients to treat nonhealing and infected groin wounds. Exposed prosthetic vascular reconstructions were covered with the PGMF in 14 wounds, and in situ autogenous vascular reconstructions were covered in four. Seven wound infections were polymicrobial, 10 had a single gram-positive organism, and one had a single gram-negative organism. Pseudomonas cultured out in four wounds, and Candida in one wound. Two patients had a virulent combination of methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococcus. Complete healing was initially achieved in all wounds, and no patient died within 30 days of surgery. Two PGMFs failed, at 2 weeks and 2 months, respectively, one from tension on the flap pedicle and one from acute inflow occlusion. Underlying prosthetic reconstruction was salvaged in 12 of 14 wounds; the remaining wounds with autogenous reconstructions or exposed femoral vessels all closed successfully. At a mean follow-up of 40 +/- 10 months there were no recurrent groin infections. Seven patients died, at 2.5, 3, 8, 12, 14, 22, and 28 months, respectively. CONCLUSION: PGMF transposition is an effective option to cover infected or exposed femoral vessels or salvage prosthetic graft material in the groin. In appropriately selected patients, when complete graft removal and extra-anatomic bypass is not an acceptable option, gracilis muscle flap coverage is a viable alternative. The technique is relatively simple, and morbidity from PGMF harvest is minimal.

Adult↗
PubMed2004

The oblique rectus abdominis musculocutaneous flap: revisited clinical applications.

The authors present their experience with a previously described but infrequently used variation of the rectus abdominis myocutaneous flap. Skin paddles angled obliquely from the line of the rectus abdominis and toward the rib cage were successfully carried on periumbilical perforators from the inferior epigastric system. Skin paddle dimensions ranged from 6.5 to 12 cm in width and from 10 to 27 cm in length in 14 consecutive patients. In six of the 14 patients, the flap was used intraabdominally to obliterate radiated pelvic defects and to close radiated vaginal defects. Five flaps were placed externally to repair radiated wounds of the perineum, thigh, and trunk, and the remaining three cases were performed as free tissue transfers. One cadaver injection study was performed to redemonstrate the preferential flow of fluid in a superior-oblique direction from periumbilical perforators. Termed the oblique rectus abdominis musculocutaneous ("ORAM") flap, this flap variation has significant advantages in terms of ease of dissection and versatility over its flap cousins the vertical rectus abdominis musculocutaneous flap and the transverse rectus abdominis musculocutaneous flap.

Aged↗
PubMed2004

The role of palmaris muscle tendon in mitral valve annulus reconstruction: a novel technique for mitral valve repair.

BACKGROUND: Autogenous tissue for heart valve repair is limited to pericardium and fascia lata. Prosthetic annuloplasty rings have limitations and are expensive. No previous cadaveric study has documented autotransplantation of forearm tendons for mitral valve repair. The purposes of this anatomical study were (1) to determine the feasibility of using tendons for annular reconstruction during mitral valve repair (band or ring shape) and (2) to compare the metric dimensions and gross morphology with those of prosthetic rings. METHODS: The palmaris tendon (PM) (n = 7) was harvested from forearms of human cadavers and prepared in the dissecting room. The tendon was incorporated along the valve annulus. Surgery consisted of mitral valve annuloplasty performed with an undersized and a complete tendon. RESULTS: On gross handling PM tissue was morphologically resilient. Preparation and use of PM for annuloplasty were feasible. Anatomical reconstruction of the annulus with autogenous tissue using this tendon also was feasible. The annulus behaved as a flexible ring that allowed for improved atrioventricular continuity. Complete (n = 7) and partial (n = 7) annuloplasty rings were constructed. Metric dimensions were similar to those of prosthetic rings. CONCLUSION: PM is a suitable novel autogenous tissue that can be harvested together with the radial artery and has direct relevance in ischemic mitral valve regurgitation. These tendons can be easily utilized to achieve results similar to those of pericardial reconstruction and prosthetic annuloplasty rings. The tissue is readily available from the patient, and no extra cost is incurred. Further chemical studies in the human subjects are warranted.

Cadaver↗
PubMed2004

Improved repair of cervical esophageal fistula complicating anterior spinal fusion: free omental flap compared with pectoralis major flap. Report of four cases.

Esophageal injury is a serious complication of anterior cervical fusion. A team approach to the management of these cases is described. The authors performed spinal assessment, control of the fistula, and interposition of a vascularized flap between the spine and the esophagus. They compared the overall efficacy of the pectoralis major flap (pedicled; two cases) and omental flap (free; two cases).

Adolescent↗
PubMed2003

Muscle flap salvage of spine wounds with soft tissue defects or infection.

STUDY DESIGN: This retrospective study was designed to analyze the results of 22 patients treated for postoperative soft tissue defects of the spine. OBJECTIVE: To demonstrate the utility of flaps in the salvage of spine wounds. SUMMARY OF BACKGROUND DATA: In the literature, the treatment of postoperative spine infections is with serial débridement, antibiotic irrigation catheters, drains, and occasional removal of spinal implants. Muscle flaps have received scant mention in the surgical literature for spine coverage. METHODS: Group 1 (n = 15) had postoperative wound infections or dehiscences. Group 2 (n = 7) had "prophylactic" flaps at the time of their initial spine surgery. The indications for "prophylactic" closure included multiple prior surgeries, prior infection, and previous radiation therapy. Group 1 was treated with drainage, dressing changes, and one-stage flap closure of their wounds. Sliding paraspinal muscle flaps were the flaps of choice. Group 2 was treated with a variety of closure techniques at the time of their initial surgery. RESULTS: The average defect size was 10 vertebral bodies long. Despite the large defect size, 19 of 20 surviving patients currently have healed wounds, and all the patients have maintained their instrumentation. Two patients died of causes unrelated to their wound problems. A Group 1 patient with complete loss of a superior gluteal artery flap was salvaged with a contralateral gluteus muscle flap. Another Group 1 patient has intermittent drainage from under a trapezius flap, which covers a cervical spine fusion. Four patients had minor wound complications. CONCLUSIONS: Flaps are a useful adjunct in the treatment of patients with complex spine wounds. Sliding paraspinal muscle flaps can effectively close wounds from the high cervical to the low lumbar area in one operative procedure. These patients can go on to successful spine fusion.

Adult↗
PubMed2003

Comparison of repair techniques for major incisional hernias.

BACKGROUND: Multiple techniques exist for repair of incisional hernias. Laparoscopic ventral hernia repairs as well as sliding myofascial rectus flap ventral hernia repairs (the separation of parts technique) have received recent attention for low recurrence and low complication rates. These procedures are diametrically opposed solutions to the same clinical problem. METHODS: Two surgeons of different surgical specialties will jointly compare and contrast these two ends of the spectrum regarding repair of ventral hernias. RESULTS: An algorithm for patient selection is presented. CONCLUSIONS: No one technique is the "best" procedure for all patients. Knowledge of the wide variety of surgical options will be of benefit to all patients with incisional hernias.

Algorithms↗
PubMed2003

Extended approach to the vascular pedicle of the gracilis muscle flap: anatomical and clinical study.

Dissection of the proximal gracilis vascular pedicle proceeds in a dark tunnel-like space deep to the adductor longus. With the application of a previously described technique for an extended approach to the lateral arm free flap, the authors describe a novel technique that improves observation and thus facilitates dissection of the proximal gracilis vascular pedicle. A retrospective review of data for 18 consecutive patients who underwent gracilis muscle free flap harvesting with this modified technique between March of 1999 and October of 2001 was conducted, to assess flap viability and patient outcomes. A cadaveric dissection was also performed, to study the anatomical features of the region in depth and to test the proposed flap modification. After the standard incision has been made, the dominant pedicle is exposed on the medial aspect of the gracilis muscle, running in a fascial cleft between the adductor longus and the adductor magnus. Intramuscular branches to the adductor longus are divided. A space is bluntly created anterior and lateral to the adductor longus by separating the fibrous connections to the surrounding adductor and sartorius muscles on both sides of the vascular pedicle. The gracilis muscle is then divided and passed deep to the adductor longus, into this space. With this new position, the final dissection of the pedicle can easily be performed. The confluence of the venae comitantes is frequently encountered, providing a larger-caliber single vein for microvascular anastomosis. The ages of the patients ranged from 9 to 70 years. The majority (14 of 18 patients) had traumatic wounds. The free flap survival rate was 100 percent. One minor complication of a seroma at the donor site was observed. One major complication of venous thrombosis was detected on postoperative day 3, with complete flap salvage. No other complications were noted. This technique is safe and permits direct approach to and excellent observation of the proximal aspect of the gracilis pedicle, without the need for headlights or deep retractors. An additional benefit is the frequent finding of a single larger vein from the merging of the venae comitantes close to the deep femoral vessels.

Adolescent↗
PubMed2003

A minimalist approach to the care of the indwelling closed suction drain: a prospective analysis of local wound complications.

Despite their long-standing and prevalent use, closed suction drains lack a standardized postoperative care protocol. The authors present a prospective analysis of local wound problems associated with a minimalist approach to care of the drain exit site. A total of 73 patients undergoing a variety of procedures had 192 closed suction drains left in place on average over 10 days after surgery. Drain care consisted of daily showering with soap and water for the skin, no dressings, and stripping and emptying of the drain by the patient. Ninety-one percent of the patients followed the drain protocol and showered postoperatively without particular attention to the drains. There were 5 major complications of fluid collections leading to open wounds, 5 minor wound complications, and 2 wound complications unrelated to drain exit site care. Patient follow-up averaged 10 months. Overall, these data underscore the safety and efficacy associated with a simple approach to the management of closed suction drains.

Adult↗
PubMed2003

Definitive surgical treatment of infected or exposed ventral hernia mesh.

OBJECTIVE: To discuss the difficulties in dealing with infected or exposed ventral hernia mesh, and to illustrate one solution using an autogenous abdominal wall reconstruction technique. SUMMARY BACKGROUND DATA: The definitive treatment for any infected prosthetic material in the body is removal and substitution. When ventral hernia mesh becomes exposed or infected, its removal requires a solution to prevent a subsequent hernia or evisceration. METHODS: Eleven patients with ventral hernia mesh that was exposed, nonincorporated, with chronic drainage, or associated with a spontaneous enterocutaneous fistula were referred by their initial surgeons after failed local wound care for definitive management. The patients were treated with radical en bloc excision of mesh and scarred fascia followed by immediate abdominal wall reconstruction using bilateral sliding rectus abdominis myofascial advancement flaps. RESULTS: Four of the 11 patients treated for infected mesh additionally required a bowel resection. Transverse defect size ranged from 8 to 18 cm (average 13 cm). Average procedure duration was 3 hours without bowel repair and 5 hours with bowel repair. Postoperative length of stay was 5 to 7 days without bowel repair and 7 to 9 days with bowel repair. Complications included hernia recurrence in one case and stitch abscesses in two cases. Follow-up ranges from 6 to 54 months (average 24 months). CONCLUSIONS: Removal of infected mesh and autogenous flap reconstruction is a safe, reliable, and one-step surgical solution to the problem of infected abdominal wall mesh.

Abdominal Wall↗