Biomedical subjects

Guang H Lu

Publications and source records attributed to Guang H Lu.

3 recordsLinked to original sources

PubMed2006

HIV sexual risk behaviors among injection drug users in Shanghai.

PURPOSE: This study investigated the sexual risk behaviors among injection drug users. (IDUs) in order to inform the development of sexual risk reduction interventions for IDUs. METHODS: A cross-sectional survey of IDUs (n=141) was conducted in an in-patient detoxification treatment center in Shanghai, China, to collect information on demographics; drug use history; sexual risk behavior; HIV/AIDS knowledge, attitudes, and other psychosocial variables; and HIV, HBV, and HCV seroprevalence. Factors associated with HIV sexual risk behaviors and HBV and/or HCV infection were analyzed. RESULTS: Sexual risk behaviors among IDUs were common: the majority (77%) of the participants had not used a condon consistently in the previous 3 months, 25.5% had multiple partners, 48.2% had IDU partners, and 75.9% did not know their partner's HIV status. IDUs who were married (OR=4.83, p<0.05) or did not intent to use condoms in the future (OR=0.21, p<0.05) were more likely to have unprotected sex. The prevalence of HBV and HCV infection was 31.9% and 51.8%, respectively, but no one tested positive for HIV.IDUs with an injection history of 3 years or more (OR=5.86, p<0.05) and with an overdose history (OR=3.21, p<0.05) were more likely to be infected with HBV and/or HCV. CONCLUSIONS: Sexual risk behaviors among IDUs in Shanghai are common, and many IDUs are vulnerable for transmission of disease. Prevention efforts with IDUs should address sexual risk behaviors in addition to needle-sharing behaviors.

Adult↗

PubMed2005

Risk behaviors and HIV/AIDS prevention education among IDUs in drug treatment in Shanghai.

We estimated seroincidence of HIV, hepatitis B virus (HBV) and hepatitis C virus (HCV), and the prevalence of risk behaviors among injection drug users (IDUs) who accepted inpatient detoxification by 14-day methadone tapering treatment in the Shanghai Drug Abuse Treatment Center. We also evaluated the effect of an HIV/AIDS prevention education intervention on those IDUs. Data including demographic characteristics, HIV, HBV and HCV seroincidence, sexual and injection-related risk behaviors were collected from 101 IDUs. All subjects received HIV/AIDS prevention education during inpatient detoxification treatment. An HIV-knowledge questionnaire was used to evaluate the effects of this intervention. We found that risk behaviors, including unsafe sex and unclean injection practices, were common among the subjects. The seroincidence of HBV and HCV infection rates was 56.4% and 46.5%, respectively, but no HIV-infected case was found among the subjects. After participating in the HIV/AIDS prevention intervention, subjects' scores (M+/-SD) on the HIV-knowledge questionnaire were significantly improved from baseline (97.29+/-7.42 vs. 31.1+/-12.1). Our study confirmed that IDUs in Shanghai are a high-risk population for blood borne diseases such as hepatitis B and hepatitis C and HIV. HIV/AIDS prevention education increased HIV knowledge, improved understanding of HIV prevention methods and changed attitudes toward HIV/AIDS. Therefore, HIV/AIDS prevention education should to be an important component of drug treatment.

Adult↗

PubMed2003

Quantitative structure-biodegradation relationship study for biodegradation rates of substituted benzenes by river bacteria.

The biodegradation rate constant (K) of 21 substituted phenols, anilines, and benzoic acids was determined by using bacteria from the Songhua River (Jilin Province, China) as an inoculum. All of the compounds studied are readily biodegradable chemicals, as shown by their high K values. The quantitative structure-biodegradation relationship results showed that the biodegradation rate of the studied compounds is related mainly to the heat of formation (Hf) and the negative logarithm of the ionization constant (pKa), whereas no simple relationship exists with the n-octanol-water partition coefficients. The equation K = - 1.127 x 10(-3)Hf - 0.0388pKa + 0.859 was found to fit well (r2(adj) = 0.805), and the correlation coefficient between the predicted and the experimental K values was up to 0.908.

Aniline Compounds↗