Biomedical subjects

Guang-zhong Tu

Publications and source records attributed to Guang-zhong Tu.

9 recordsLinked to original sources

PubMed2005

[A new natural product from the roots of Hedysarum multijugum].

OBJECTIVE: To study the chemical constituents of the roots of Hedysarum multijugum Maxim. METHODS: Compounds were isolated and purified by solvent and column chromatographic methods, and their structures were determined on the basis of physico-chemical properties and spectroscopic data. RESULTS: Seven compounds warangalone-4'-methyl ether (1), afrormosin (2), sissotrin (3) and ononin (4), naringenin-5, 7-di-O-beta-D-glucopyranoside (5), apigenin (6) and narcissin (7) were obtained from the roots of Hedysarum multijugum. CONCLUSION: Compound 1 is a new natural product, and other compounds; are obtained from the plant for the first time.

Apigenin↗

PubMed2005

An antitumor compound julibroside J28 from Albizia julibrissin.

A new triterpenoid saponin, julibroside J(28) (1), was isolated from the stem bark of Albizia julibrissin Durazz (Leguminosae) by using chromatographic method. The structure of 1 was established by spectroscopic methods. 1 displayed significant antitumor activity in vitro against PC-3M-1E8, Bel-7402, and HeLa cancer cell lines at 10 microM assayed by SRB method.

Antineoplastic Agents, Phytogenic↗

PubMed2005

Diastereoisomeric saponins from Albizia julibrissin.

The structures of four new diastereoisomeric triterpenoidal saponins Julibroside J5, J8, J12 and J13 (1-4) isolated from Albizia julibrissin Durazz. (Leguminosae) have been determined on the basis of comprehensive spectroscopic analysis and chemical degradation. Julibroside, J8 and J13 showed marked cytotoxic activities against Bel-7402 cancer cell line at 100 microg/mL.

Albizzia↗

PubMed2005

[Studies on lignan glycosides from the roots of Bupleurum scorzonerifolium].

AIM: To study the lignan glycosides from the roots of Bupleurum scorzonerifolium. Chromatography methods was used to isolate compounds and chemical and spectral methods were used to identify the structures of isolated compounds. RESULTS: Two lignan glycosides were isolated from the roots of B. scorzonerifolium and their structures were identified as 2, 3-E-2,3-dihydro-2-(3'-methoxy-4'-O-beta-D-glucopyranosyl-phenyl)-3-hydroxymethyl-5-(3"-hydroxypropenyl )-7-methoxy-1-benzo [b] furan (1) and 2, 3-E-2, 3-dihydro-2-( 3'-methoxy-4'-hydroxy-phenyl)-3-hydroxymethyl-5-( 3"-hydroxypropenyl)-7-O-beta-D-glucopyranosyl-1-benzo[b]furan (2), both of them which were the mixture of (+)2S,3R- and (-)2R,3S-type diastereoisomer and in both of them the amount of (+)2S,3R-type was a little more than that of the (-)2R,3S-type. CONCLUSION: Compounds 1 and 2 were isolated from B. scorzonerifolium for the first time. (+)2S, 3R-2, 3-Dihydro-2-(3'-methoxy-4'-hydroxy-phenyl)-3-hydroxymethyl-5-(3"-hydroxypropenyl)-7-O-beta-D-glucopyranosyl-1-benzo[b] furan is a new compound.

Bupleurum↗

PubMed2004

Isolation and identification of a novel ellagitannin from Phyllanthus urinaria L.

AIM: To investigate the chemical constituents of Phyllanthus urinaria L. METHODS: Various chromatographic techniques were employed for the isolation and purification. The structure was elucidated by spectral analyses. RESULTS: A novel ellagitannin named phyllanthusiin G was isolated, its structure was established as 1-O-galloyl-2-phyllanthoyl-3,6-(R)-HHDP-beta-D-glucose. CONCLUSION: Phyllanthusiin G is a new compound.

Molecular Conformation↗

PubMed2003

[Studies on the chemical constituents from the aerial parts of Cimicifuga dahurica].

AIM: To seek for new bioactive constituents from the aerial parts of Cimicifuga dahurica. METHODS: Various column chromatographic techniques were employed for the isolation and purification of the ingredients. The structures were elucidated on the basis of 1H, 13CNMR, 1H-1H COSY, HMQC, NOESY and HMBC spectra and chemical reactions. RESULTS: Two cyclolanostanol xylosides, cimidahuside C and D were isolated from the EtOAc section of EtOH extracts. CONCLUSION: Cimidahuside C(1) and D(2) are new triterpenoid xylosides.

Cimicifuga↗

PubMed2003

[Structure identification of jujuboside E].

AIM: To study the chemical constituents of the seeds of Ziziphus jujuba Mill var. spinosa (Bunge) Hu ex. H.F. Chou. METHODS: To separate the constituents by using various kinds of chromatography methods and identify their structures on the basis of spectral analysis. RESULTS: Seven compounds were isolated. Their structures were established as jujuboside E (1), jujuboside B (2), jujuboside A (3), betulic acid (4), stearic acid (5), sucrose (6) and inosine (7). CONCLUSION: Compound 1 is a new compound named jujuboside E. Compounds 5, 6, 7 were isolated for the first time from this plant.

Inosine↗

PubMed2003

[Studies on chemical constituents in fruits of Tibetan medicine Phyllanthus emblica].

OBJECTIVE: To investigate the chemical constituents of Tibetan medicine Phyllanthus emblica. METHOD: Various chromatographic techniques were employed for isolation and purification of the constituents, and the structures were elucidated by chemical and spectral analyses. RESULT: 11 compounds were isolated and identified as gallic acid (I), ellagic acid (II), 1-O-galloyl-beta-D-glucose (III), 3,6-di-O-galloyl-D-glucose (IV), chebulinic acid (V), quercetin (VI), chebulagic acid (VII), corilagin (VIII), 3-ethylgallic acid (3-ethoxy-4,5-dihydroxy-benzoic acid, IX), isostrictiniin (X), 1,6-di-O-galloyl-beta-D-glucose (XI). CONCLUSION: 3-Ethylgallic acid (3-ethoxy-4,5-dihydroxy-benzoic acid) is a novel compound, and isostrictiniin was found from P. emblica for the first time.

Ellagic Acid↗

PubMed2002

Beesiosides A-F, six new cycloartane triterpene glycosides from Beesia calthaefolia.

Six new cycloartane triterpene glycosides (1-6), beesiosides A-F, were isolated from whole plants of Beesia calthaefolia, and their structures were elucidated on the basis of extensive NMR experiments and chemical methods. Beesiosides A-F were assigned as (20S,24R)-epoxy-9,19-cyclolanostane-3beta,16beta,18,25-tetraol-3-O-beta-D-xylopyranoside (1), (20S,24R)-epoxy-9,19-cyclolanostane-3beta,12beta,16beta,18,25-pentaol-3-O-beta-D-xylopyranoside (2), (20S,24R)-epoxy-9,19-cyclolanostane-3beta,12alpha,16beta,18,25-pentaol-3-O-beta-D-xylopyranoside (3), (20S,24R)-16beta-acetoxy-20,24-epoxy-9,19-cyclolanostane-3beta,12alpha,18,25-tetraol-3-O-beta-D-xylopyranoside (4), (20S,24R)-epoxy-9,19-cyclolanostane-3beta,15alpha,16beta,18,25-pentaol-3-O-beta-D-xylopyranoside (5), and (20S,24R)-16beta-acetoxy-20,24-epoxy-9,19-cyclolanostane-3beta,12beta,25-triol-3-O-beta-D-xylopyranoside (6), respectively.

Chromatography, Thin Layer↗