Biomedical subjects

Guangbo Zhang

Publications and source records attributed to Guangbo Zhang.

3 recordsLinked to original sources

PubMed2005

[Femoral varus osteotomy combined with interlocking nailing for treatment of genu valgum].

OBJECTIVE: To assess the effect of medial distal femoral osteotomy combined with interlocking nailing on the treatment of knee osteoarthritis with valgus deformity. METHODS: From May 1996 to August 2000, 16 patients with knee osteoarthritis accompanied by valgus deformity were treated by medial wedged distal femoral osteotomy combined with interlocking nailing. Full-length radiographs were taken before operation and 8 weeks and 2 years after operation. The parameters, including the femorotibial angle, the tibial angle, the femoral angle, the femoral condyle-tibial plateau angle, and the lateral joint space, were measured by these radiographs. The function of knee was evaluated by the 100-point rating scale standard of knee. RESULTS: The mean postoperative score was significantly improved from 50.4 +/- 15.9 points to 78.5 +/- 12.9 points 2 years after the surgery. The lateral joint space was increased from 2.1 +/- 1.8 mm to 4.7 +/- 1.7 mm and the femoral condyle-tibial angle decreased from 5.6 +/- 2.9 degrees to 1.6 +/- 3.4 degrees. There were complications in 2 cases: 1 case of delayed union and 1 case of superficial wound infection. CONCLUSION: Medial distal femoral osteotomy combined with interlocking nailing proves to be an effective approach to treat knee osteoarthritis with valgus deformity.

Adult↗

PubMed2005

B7-H3: another molecule marker for Mo-DCs?

Using a newly generated monoclonal antibody (2E6) against human B7-H3, we explored the expression of the molecule on dendritic cells derived from monocytes (Mo-DCs). Its expression was examined by means of immunostaining and flow cytometric (FCM) analysis. The results showed that B7-H3 was expressed in the course of Mo-DC maturation induced with interleukin 4 (IL-4) and granulocyte/macrophage colony-stimulating factor (GM-CSF). The expression could be detected at all the stages of Mo-DC differentiation, and remained at a quite stable level. Interestingly, B7-H3 was not expressed by T cells and B cells, even these cells were activated respectively by PHA or PWM. A weak expression could be detected on resting monocytes. These data showed that constitutive expression of B7-H3 at a high level was found on imDCs and mDCs derived from monocytes. Due to no expression on T cells and B cells, we speculate that B7-H3 might be another valuable molecule marker for Mo-DCs.

Animals↗

PubMed2003

Morphometric evaluation of screw fixation in atlas via posterior arch and lateral mass.

STUDY DESIGN: This study is a result of manual and radiologic measurements of 50 isolated anatomic specimens of C1 and five patients of atlantoaxial instability treated by screw fixation via posterior arch and lateral mass. OBJECTIVES: To investigate the feasibility of screw placement via posterior arch and lateral mass in atlas. SUMMARY OF BACKGROUND DATA: Several types of posterior approaches have been adopted for stabilization and fusion of atlantoaxial complex. Before this study, Gallie in 1939 gave a report on a posterior wiring technique that depended on a structural bone graft. Since then, double-looped wiring with two bone grafts and Halifax clamp technique had been introduced. A transarticular screw fixation technique was introduced by Magerl and Seeman in 1987, and a C1 lateral mass screw fixation technique was described by Harms in 2001. However, the feasibility of screw fixation in atlas via posterior arch and lateral mass has not been addressed until now. METHODS: Fifty dry samples of atlas were measured manually and radiologically with vernier calipers, protractors, and CT. The parameters of posterior arch, lateral mass, vertebral artery groove, axis length of screw path via posterior arch and lateral mass, the entry point, and screw direction were measured. Five patients of atlantoaxial instability were treated with this technique and the radiographs and CT scans were evaluated after surgery. RESULTS: The longest trajectory distance of the screw path was about 30 mm. The outer thickness at the thinnest part of groove was 4.58 mm, and it was found to be <4 mm in four cases (8%). The entry point is 18-20 mm lateral to the midline and 2 mm superior to the inferior border of posterior arch. The direction of screw placement is perpendicular to the coronal plane and about 5 degrees cephalad to the transverse plane. Ten screws via posterior arch and lateral mass were placed properly, without incidence of nerve or blood vessel injury in clinical practice. CONCLUSION: Atlas is capable for screw fixation via its posterior arch and lateral mass.

Adult↗