[The effect of matrine on the expression of P170 LRP and TOPO II of obtained multi-drug resistance of mouse S180's tumour cell].
OBJECTIVE: To observe the effect of matrine on P170 expressed by multi-drug resistance gene, lung resistant protein (LRP), and boposomeras II. METHODS: By the method of less dosage of chemotherapy PFC, the mouse model of multi-drug resistance of S180 tumour cell was set up. At the same time, matrine was administered to the mouse model for 4 weeks, and then P170 LRP, TOPO II were observed by flow cytometry. RESULTS: Martine can obviously reduce the express of P170, LRP and the activity of TOPO II in multi-drug resistance tumour cell induced by chemotherapy. CONCLUSION: Matrine can intervene the occurrence of the multi-drug resitance of tumor cells induced by chemotherapy.
ATP Binding Cassette Transporter, Subfamily B, Mem↗