Biomedical subjects

Guo-hua Lu

Publications and source records attributed to Guo-hua Lu.

4 recordsLinked to original sources

PubMed2005

[Surgical treatment of thoracic vertebral angioma with extraosseous extension causing spinal cord compression].

OBJECTIVE: To evaluate the therapeutical effect of surgical treatment for thoracic angioma with extraosseous extension which causes spinal cord compression and neurological dysfunction. METHODS: We retrospectively analyzed 5 cases of thoracic vertebral body angioma with extraosseous extension and spinal cord compression. The operation were performed through anterior approach to resect the involved vertebral body and intracanal angioma in 5 patients. Bone graft and internal fixation were also completed in the meantime. Two patients accepted radiotherapy for 2 periods of treatment postoperatively, and the other 3 patients didn't accept the other supportive therapy. RESULTS: The blood loss during the operation was 1000 mL to 1500 mL. All the patients recovered their neurological function rapidly after the operation. The patients were followed up for 1 to 4 years, and no patient recurred. The bone graft was solidly fused in all patients. No hardware failure occurred. CONCLUSION: The surgical treatment for thoracic vertebral body and extraosseous angioma with spinal cord compression is effective, reliable, and workable. Good long-term result can be obtained.

Adult↗

PubMed2005

[Cervical pedicle screw in the treatment of cervical fracture complicating ankylosing spondylitis].

OBJECTIVE: To determine the effect of cervical pedicle screw in the treatment of cervical fracture complicating ankylosing spondylitis. METHODS: A retrospective study was done in 5 patients of cervical fracture complicating ankylosing spondylitis who were treated with cervical pedicle screw. According to Frankel's standard, 1 patient was in Grade A, 2 patients in Grade B and 1 patient in Grade C and 1 patient in Grade D. All patients were treated with decompression, fusion and posterior fixation with cervical pedicle screw. RESULTS: The average bony healing time was 3.6 months (3.1 to approximately 4.5 months). The instrumentation was not loose, pulled-out or ruptured. Only one C6 pedide was perforated and the vertebral artery was broken, but there was no new postoperative symptom. Three of the patients with neurological deficits improved postoperatively but the other two who were in Grade A were remained unchanged. CONCLUSION: The good biomechanical characteristics of cervical pedicle screw help the successful treatment in the application of cervical fracture complicating ankylosing spondylitis.

Adult↗

PubMed2004

Study on a non-contact life parameter detection system using millimeter wave.

OBJECTIVE: To study the basic principle and design method of a non-contact life detection system using 36 GHz millimeter wave. METHOD: Continuous wave radar techniques and signal processing techniques including zero intermediate frequency, frequency domain accumulation and adaptive noise cancellation were used in the system. RESULT: When the radiated power was about a milliwatt (mW) and detection range was up to 3 meters, the experimental results showed that this system can well detect the heartbeat and respiration signals from human subjects through common clothes and quilts. CONCLUSION: The system is feasible and effective due to its high detection sensitivity, small antenna, simple structure, easy miniaturization and safety to the human subject. It can be used for long-term continuous monitoring, especially suitable for the astronauts.

Aerospace Medicine↗

PubMed2003

[Fibrillin-1 gene mutation in Chinese patients with Marfan syndrome and its gene diagnosis by haplotype analysis].

OBJECTIVE: To analyze fibrillin-1 (FBN(1)) gene mutation in Chinese patients with Marfan syndrome(MFS) and to make a gene diagnosis by haplotype analysis for MFS. METHODS: Nine MFS families were analysed with single strand conformation polymorphism(SSCP) and DNA sequencing. With the use of four primers designed in the flanking sequences of each short-sequence tandem-repeat region in FBN(1) gene, the haplotype-segregation analysis for MFS(B) was performed. RESULTS: In MFS(A)II(1), PCR-SSCP detected SSCP band alterations in exon 25 of FBN(1) gene; direct sequencing showed a small 13bp deletion, the deleted sequence being gcctctgcaccca at base 3243-3456 of cDNA. This mutation caused a frame-shift which was never seen in any unaffected members of the family, and it was a heterozygous mutation; neither of them was identified in 100 chromosomes from 50 normal control individuals. Haplotype-segregation analysis suggested that the disease was passed from Subject I(2) to Subject II(2), Subject II(3), Subject II(5) with the same allele in MFS B family, the proband's daughter also inherited the allele. These data indicated that MFS(B) family was linked to FBN(1) gene, the proband's daughter was an asymptomatic patient. CONCLUSION: The combination of mutation analysis and haplotype analysis can provide more evidence for gene diagnosis.

Base Sequence↗