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Guoliang Tao

Publications and source records attributed to Guoliang Tao.

3 recordsLinked to original sources
PubMed2006

[A study on clustering analysis of arrhythmias].

According to the characteristics of ECG analysis, large data quantum, high accuracy demand and real-time, a classified algorithm of arrhythmia based on clustering analysis is presented in this paper. According to "things-of-one-kind-come-together" principle, this algorithm uses the similarities of cases with same kind of heart disease at the same time, includes the factors of the individual difference to analyze arrhythmias by clustering QRS complex waveform and rhythm analysis as the subordinate method. Verified by eight records of MIT-BIR standard heart electricity database, the probability of correct clustering reaches above 90%, which shows that this algorithm can analyze arrhythmias effectively.

Algorithms↗
PubMed2003

A benchmark study with sealchip planar patch-clamp technology.

Although conventional patch-clamp methods provide high information content, they are labor-intensive and suffer from low throughput and high overall cost. Several approaches for achieving high throughput electrophysiology are under development, among which microchip-based patch-clamp systems uniquely achieve a higher degree of miniaturization, faster perfusion and mixing, and lower reagent cost without losing information content. The goal of this study was to establish a benchmark for our biochip technology with 52 chips tested sequentially. We demonstrate that our microfabrication and processing technology is sufficiently mature to produce a consistent hole size. We further demonstrate high-quality planar whole-cell patch clamping with >75% overall success rate at achieving gigaohm seals, followed by stable whole-cell access lasting at least 15 min with access resistance (Ra) below 15 MOmega and membrane resistance (Rm) above 200 MOmega. These biochips are ideally suited for high throughput compound screening for ion channel targets.

Animals↗