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Biomedical subjects

Gurkan Kiran

Publications and source records attributed to Gurkan Kiran.

12 recordsLinked to original sources
PubMed2006

Are changes in urinary parameters during pregnancy clinically significant?

We aimed to objectively determine changes in the various urinary parameters along with CaOx saturation level during pregnancy. The study included 15 pregnant women who had no known diseases and were taking no medication except prenatal supplements. Mean age of the patients was 26 years (range 20-30). In all of them, this study was carried out in each trimester and 3 months post partum. All participants were followed up, and blood and urine samples were obtained during the pregnancy and during 3 months post partum. All subjects collected 24-h urine samples. The pregnant women had hypercalciuria in all three trimesters. Except for the first trimester, urine calcium levels in all trimesters were significantly higher when compared with the post-partum period (P<0.01 for second trimester, P<0.05 for third trimester). Urine oxalate level in post-partum period was significantly higher than urine oxalate levels in each trimester (P<0.05). The urine citrate levels were similarly higher than normal levels in three trimesters. Urine citrate level of the post-partum period was in normal reference ranges. This difference was not statistically significant (P>0.05). We believe that hypercalciuria encountered at pregnancy is a reversible physiologic condition. Also, citrate and magnesium as urinary inhibitors increased in urine during gestation preventing stone formation. We think that long time periods are needed for hypercalciuria to be able to lead to the formation of urinary calculi in pregnant women (except women having a positive family history). Therefore, we think that the pregnancy alone does not predispose to a suitable condition for calculi.

Calcium↗
PubMed2005

Short-term effects of hormone therapy on serum C-reactive protein levels in postmenopausal women.

OBJECTIVES: The aim of this study was to investigate the effects of tibolone and conjugated equine estrogens (CEEs) plus medroxyprogesterone acetate (MPA) (CEE + MPA) on levels of serum C-reactive protein (CRP), an independent risk factor for cardiovascular disorders, in postmenopausal women. STUDY DESIGN: In this prospective randomized study, we randomly assigned 58 healthy postmenopausal women to CEE (0.625 mg/day) plus MPA (2.5 mg/day) (CEE + MPA) or tibolone (2.5 mg/day). The serum levels of CRP at 3 months after starting treatment were compared with baseline values for both therapies. RESULTS: After 3 months of treatment the median CRP levels increased by 29% in the CEE + MPA group and by 5% in the tibolone group. But, these changes did not have statistical significance (P=0.15, P=0.06, respectively). CONCLUSIONS: Our findings show that neither tibolone nor CEE + MPA caused significant changes in serum CRP levels in postmenopausal women. The potential impact of hormone therapy on serum CRP levels should be investigated in ongoing clinical trials.

C-Reactive Protein↗
PubMed2005

Tuba uterina leukemia inhibitory factor concentration does not increase in tubal pregnancy: a preliminary study.

The aim of the present study was to compare the levels of leukemia inhibitory factor (LIF) in the tubal ampullary region in normal and ectopic pregnancies and assess possible causative role of LIF in ectopic pregnancy. Although there was a tendency of increase in LIF concentrations in the ectopic pregnancy group, we were not able to determine a statistically significant difference between the two groups.

Fallopian Tubes↗
PubMed2005

Ovarian cortical transplantation may be an alternative to hormone therapy in patients with early climacterium.

OBJECTIVE: To discuss the 18-month follow-up results of fresh ovarian cortical tissue transplant. DESIGN: Case study. SETTING: Academic medical center. PATIENT(S): A 46-year-old patient who was operated on for uterine fibroids, and who then received an ovarian tissue transplant in July 2003. INTERVENTION(S): Serum hormone levels were measured at 3-month intervals. MAIN OUTCOME MEASURE(S): Follicular development evident by ultrasound examination; serum hormone levels (FSH, LH, E2). RESULT(S): Preoperative and 3rd-, 6th-, 9th-, 12th-, 15th-, and 18th-month hormone levels were, respectively, as follows: FSH: 9.06, 79.5, 13.7, 16.66, 51.91, 44.37, and 24.17 mIU/mL; LH: 5.91, 33.92, 8.78, 21.83, 38.31, 40.85, and 22.4 mIU/mL; E2: 166, 46, 48, 117, 31, 14.4, and 137.7 pg/mL. Folliculogenesis was confirmed by ultrasonography at the 6th, 9th, and 18th months during the follow-up period. CONCLUSION(S): Fresh ovarian autotransplantation may be a logical alternative for hormonal support for a specific patient group.

Climacteric↗
PubMed2005

Maternal serum and umbilical cord tumor marker levels at term pregnancy.

BACKGROUND: The aim of the study was to compare the levels in fetal and maternal compartments of cancer antigen (CA) 125, CA 15-3, carbohydrate antigen (CA) 19-9, and carcinoembryonic antigen (CEA) and to determine the effects of fetal sex, parity, and fetal weight on umbilical cord (UC) and maternal serum (MS) levels of these markers. METHODS: MS and UC levels of these markers were determined in blood samples taken simultaneously during cesarean delivery for 53 cases. All statistical analyses were performed using nonparametric tests (Wilcoxon's signed rank test, Mann-Whitney U-test, Kruskal-Wallis anova). Correlations were evaluated with Spearman's rank correlation coefficients. RESULTS: All marker levels of MS were significantly different to those of UC. There was no association between MS and UC levels of four markers and fetal sex. No significant difference could be demonstrated between fetal weight and marker levels in MS and UC. No significant difference could be demonstrated between parity and marker levels except CEA in MS that was elevated in multigravida group. CONCLUSIONS: Our results support that all markers except CA 15-3 have oncofetal origin. We concluded that further studies are required to reveal the effects of fetal sex on MS CA 19-9 and effects of parity on MS CEA levels.

Adult↗
PubMed2004

Effects of intranasal estradiol treatment on serum lipoprotein(a) and lipids in hysterectomized women.

The aim of the present study was to evaluate the effects of intranasal estradiol on lipid metabolism and lipoprotein(a) [Lp(a)] levels. A prospective comparative study was designed: 49 hysterectomized, healthy postmenopausal women received intranasal 17beta-estradiol (E2; 300 microg/day). Blood samples were collected at baseline and at the end of the 3 and 6 months of therapy. After 6 months, the serum levels of total cholesterol, LDL-cholesterol and triglycerides did not show any significant change with intranasal 17beta-E2 therapy. HDL-cholesterol levels at 3 and 6 months of treatment were significantly increased compared with baseline levels (p = 0.031, p = 0.000, respectively). There was a significant change in serum Lp(a) levels at the 6th month (p = 0.003) but not at the 3rd month (p = 0.183) compared with the baseline levels. Further studies are needed to detect whether these changes are significant and permanent or not.

Administration, Intranasal↗
PubMed2004

Fresh autologous transplantation of ovarian cortical strips to the anterior abdominal wall at the pfannenstiel incision site.

OBJECTIVE: To describe an open surgical technique for transplanting fresh ovarion tissue to the anterior abdominal wall at the incision site and to determine whether ovarian function would be restored after transplantation. DESIGN: Case study. SETTING: Academic medical center. PATIENT(S): A 44-year-old patient who underwent an operation for uterine fibroids. INTERVENTION(S): Microsurgical reconstruction of ovarian cortex and its transplantation to the anterior abdominal wall at incision site of Pfannenstiel. MAIN OUTCOME MEASURE(S): Follicular development evident by ultrasound examination; restoration of serum FSH and LH levels to nonmenopausal range; and disappearance of menopausal symptoms. RESULT(S): Early postoperative FSH, LH, and E(2) levels showed that menopause was confirmed. Postoperative hormone levels at months 2, 3, and 6 were as follows: FSH: 77.86, 79.50, and 13.70 mIU/mL; LH: 34.60, 33.92, and 8.78 mIU/mL; E(2): 29, 46, and 48 pg/mL. The patient is still followed-up for postmenopausal status. CONCLUSION(S): Autotransplantation of cortical strips to the anterior abdominal wall at the incision site without further incision can be a logical solution for the patients at early climacteric age.

Abdominal Muscles↗
PubMed2004

Effects of oestrogen replacement therapy on serum C-reactive protein levels in hysterectomised women.

BACKGROUND: It has been hypothesised that oral oestrogen replacement therapy may increase levels of C-reactive protein (CRP), a marker of inflammation associated with increased risk of future cardiovascular events. However, it is possible that intranasal oestrogen replacement therapy have different effects on serum CRP levels. AIM: To investigate the effect of postmenopausal intranasal oestrogen replacement therapy on serum levels of CRP. A prospective comparative study was carried out. METHODS: Twenty-nine healthy hysterectomised, postmenopausal women received 300 micro g/day of intranasal 17beta-oestradiol (E2). The serum levels of CRP after 3 and 6 months after starting treatment were compared with baseline values. RESULTS: There were no significant changes in the values of CRP after 3 and 6 months of treatment (P = 0.305, P = 0.149, respectively). CONCLUSIONS: The data from the present study suggest that intranasal administration of E2 does not affect CRP levels, possibly by avoiding a hepatic first-pass effect. The possible cardiovascular protective role of intranasal oestrogen might be related to its effect of not increasing CRP levels.

Administration, Intranasal↗
PubMed2003

Pseudocyst of the umbilical cord with mucoid degeneration of Wharton's jelly.

The perinatal findings of a pregnancy complicated by an umbilical cord abnormality associated with mucoid degeneration of Wharton's jelly are presented. Serial ultrasound examinations were not performed because the patient did not visit our outpatient department regularly. The umbilical cord cyst was not detected on ultrasound until delivery.

Cesarean Section↗
PubMed2003

Serum lipid and lipoprotein changes induced by preparations containing low-dose ethinylestradiol plus levonorgestrel.

The purpose of the present study was to evaluate the effects on lipid metabolism of a new low-dose monophasic combination oral contraceptive with 100 microg levonorgestrel and 20 microg ethinylestradiol. Sixty healthy women aged 18-45 years were administered the medication during three cycles. The study participants were screened for lipid changes. The differences in cholesterol and triglyceride levels were not statistically significant, but high-density lipoprotein levels were significantly lower and low-density lipoprotein levels were significantly higher than the baseline. Women at risk of cardiovascular disease should be carefully monitored even when using low-dose preparations.

Adult↗
PubMedDate not supplied

Relationship between oxidative stress in cord blood and route of delivery.

OBJECTIVE: To investigate the effect of route of delivery on the antioxidant system of newborns. METHODS: We used the cord blood taken during labor of 56 vaginal deliveries and 50 elective cesarean sections. The specimens were analyzed for the plasma malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT) and glucose 6-phosphate dehydrogenase (G6PD) activity and leukocyte count. RESULTS: SOD and CAT activities were significantly higher in the elective cesarean group than the vaginal delivery group (p < 0.01 and p < 0.005, respectively), but G6PD activity was similar between the groups. Plasma MDA level was lower in the cesarean group compared to the vaginal delivery group (p < 0.001). Leukocyte count was higher in the vaginal delivery group (p < 0.005). CONCLUSION: Our findings suggest that the route of delivery has an effect on oxidative stress in newborns exposed to oxidative stress during delivery. It can be suggested that the antioxidant system works more efficiently to overcome oxidative stress in newborns delivered via cesarean section.

Antioxidants↗