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Biomedical subjects

H A Azar

Publications and source records attributed to H A Azar.

At least 37 records · Page 2Linked to original sources
PubMed1979

The laboratory diagnosis of plasma cell myeloma and related disorders.

Plasma cell myeloma constitutes the commonest primary malignant tumor affecting the skeleton of the adult. It is also one of several forms of monoclonal gammopathy that include Waldenström's macroglobulinemia, the heavy chain diseases, "benign" (nonprogressive, asymptomatic) monoclonal gammopathy, and primary amyloidosis. The diagnosis of classic or advanced myeloma rests on the findings of sheets of plasmacytic cells in a bone marrow biopsy sample or aspirate; a serum monoclonal immunoglobulin usually of the IgG or IgA class or Bence Jones protein in the urine; and evidence of multiple lytic lesions in x-ray views of the skeleton. Pitfalls in the diagnosis of earlier or unusual forms of myeloma require a careful application of classic diagnostic criteria or of criteria established by clinical cooperative groups.

Bence Jones Protein↗
PubMed1975

Significance of the Reed-Sternberg cell.

Our concept of the Reed-Sternberg cell has evolved considerably since the turn of the century. At the present, it is generally accepted that this cell is a polyploid lymphoreticular cell incapable of mitotic division. The two nuclei of the classic Reed-Sternberg cell probably represent the two lobes of a markedly convoluted or segmented nucleus. The Reed-Sternberg cell may be regarded as the end stage of a transformed lymphocyte that has undergone in vitro blastogenesis. It is not definitely known whether it is of the T or B cell variety. There seems to be no valid histochemical or ultrastructural evidence that it is a histiocyte. The Reed-Sternberg cell, although not 'pathognomonic,' continues to be an essential landmark for the diagnosis of Hodgkin's disease. The actively dividing cells in the neoplasm are considered to be the small lymphocytes as well as the mononucleated reticulum cells, although the triggering mechanism for cell division remains unknown.

Biopsy↗
PubMed1975

Problems in the development of a clinically oriented program in electron microscopy.

The educational, organizational, and fiscal aspects of electron microscopy are discussed.. with emphais on the desirability of making electron microscopy an integral part of the formal training of residents in pathology and of the overall educational program of the medical staff. The rapidity of feedback of information from the pathologist to the clinician is stressed. The number of specimens processed and the variety of tissues submitted for electron microscopy can be regulated by the pathologist but should reflect the particular strength of the hospital or its department of pathology. The organization of the electron microscopy facility, its funding, and sharing of the electron microscopy program in the local community of clinical scientists are discussed

Biopsy↗