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H A Drost

Publications and source records attributed to H A Drost.

5 recordsLinked to original sources
PubMed2001

Adductor spasmodic dysphonia and botulinum toxin treatment: the effect on well-being.

Adductor spasmodic dysphonia (AdSD) is a controversial and enigmatic voice disorder. It is generally accepted that it has a neurologic, although undetermined, cause, and it is accompanied by much psychological and physical distress. In this prospective study, standardized psychometric tests were used to assess the personality characteristics and psychological and somatic well-being of 46 patients with AdSD. Moreover, the effect of botulinum toxin (Botox) treatment on their well-being was evaluated. No significant differences could be detected between patients and a representative norm group concerning 7 personality characteristics. Nevertheless, before treatment, there were significantly more psychological and somatic complaints. After establishment of a normal to near-normal voice with Botox injections, these complaints were reduced to normal levels--a finding suggesting these phenomena to be secondary to the voice disorder. These findings, and the normal personality characteristics, do not support a psychogenic cause of AdSD.

Adult↗
PubMed2000

Perceptual characteristics of adductor spasmodic dysphonia.

The evaluation of perceptual symptoms is one of the mainstays in the diagnostic workup of adductor spasmodic dysphonia (ADSD). The most widely used perceptual rating system is the GRBAS scale. However, with this system, not all audible features of ADSD can be described. Therefore, we extended the GRBAS system by 6 parameters. The aim of this study was assessment of the perceptual characteristics of ADSD with the "extended" GRBAS system and evaluation of its reproducibility. Seventy-seven patients were scored independently by 3 experienced observers quantifying the voice sound profile. Cluster analysis distinguished 4 different voice types. Intraobserver and interobserver agreement among 8 less-experienced observers appeared fair-to-good. This study demonstrates that the "extended" GRBAS system is suitable for perceptual characterization of ADSD. On the grounds of the fair-to-good interobserver variability, it is appropriate for clinical use. Moreover, 4 different voice clusters of ADSD were identified, with significant differences in voice and demographic parameters.

Adult↗
PubMed1998

Unilateral versus bilateral botulinum toxin injections in adductor spasmodic dysphonia.

Thyroarytenoid injection of botulinum toxin is the therapy of choice in spasmodic dysphonia. However, there is no convincing evidence as to whether unilateral or bilateral injections are to be preferred. For this reason, a prospective study was designed in which voice quality, duration of effect, and side effects were assessed. Twenty-seven patients with adductor spasmodic dysphonia were treated with percutaneous injections of botulinum toxin. The first treatment consisted of injection of 5 units in the left thyroarytenoid muscle. The second treatment, 2.5 units in both sides, took place when the effect of the first procedure had completely ceased. All patients underwent both procedures. By means of self-rating scales, effects and side effects were assessed over at least 3 months. There was no difference between the procedures in duration of voice improvement, nor in the occurrence of breathy dysphonia. After a bilateral injection, statistically more patients reported swallowing problems. However, most patients preferred the bilateral injection, in spite of more and longer-lasting side effects.

Adult↗