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Biomedical subjects

H A Edmondson

Publications and source records attributed to H A Edmondson.

At least 19 recordsLinked to original sources
PubMed1986

Spontaneous liver cell adenoma in children.

The clinical and pathologic features observed in five children with spontaneous liver cell adenoma are described. All tumors showed benign biologic behavior. Two patients had untreated tumors that were followed for 5 years and 26 years, respectively, and showed no evidence of malignant transformation; the latter tumor unprecedentedly showed signs of spontaneous regression over time. Unusual physical findings associated with the liver cell adenomas included generalized osteoporosis, urticaria, and koilonychia. Microscopically, the liver cell adenomas were composed of cords, rarely sheets, of neoplastic hepatocytes with negligible pleomorphism and rare to absent mitoses; bile ducts, portal tracts, and central veins were absent. A fibrous capsule was present in all cases. Previously undescribed histologic features of this tumor type included focal extramedullary hematopoiesis and multinucleate giant cell formation in association with tumor necrosis. Benign neoplasms of the type described in this and previous studies probably should be managed conservatively.

Carcinoma, Hepatocellular↗
PubMed1985

Cystadenoma with mesenchymal stroma (CMS) in the liver and bile ducts. A clinicopathologic study of 17 cases, 4 with malignant change.

This study of 17 cases describes a homogeneous clinicopathologic group of tumors previously subsumed under the general term, hepatobiliary cystadenoma. This unique group of neoplasms that the authors have termed "cystadenoma with mesenchymal stroma" (CMS), occurred exclusively in women and showed two essential tumor components: a cyst lining of columnar to cuboidal, mucin secreting epithelium; and a moderately to densely cellular stroma composed of spindle (rarely oval) cells. The stromal element appeared similar to primitive mesenchyme, both on light and electron microscopic study, showing variable differentiation toward fibroblasts, smooth muscle, adipose tissue and capillaries. Cases of hepatobiliary "cystadenoma" in the literature with histology similar to CMS had similar sex and age incidences, while histologically dissimilar cases, lacking the mesenchymal stroma, had significantly different parameters. Four cases of CMS in this series showed malignant change that was manifested as papillary adenocarcinoma, suggesting the need for complete surgical removal of these premalignant neoplasms.

Adult↗
PubMed1985

Coelomic fat ectopia in the liver.

We describe a pedunculated, mesothelial-covered liver mass contained in a mesothelial-lined sac. Microscopically, the mass was composed of mature adipose tissue that contained thick-walled arteries and large veins, fibrous tissue, and numerous bundles of smooth muscle. The lesion was thought to represent ectopic coelomic mesenchyme originally destined to form omentum or mesentery. The existence of this entity suggested that previously reported cases of hepatic adipose tissue masses (lipomas) might also have derived from ectopic coelomic mesenchyme. Along with the mesenchymal lesion in the liver, an unclassifiable mesenchymal tumor was present in the cerebellum. Whether the coexistence of the two mesenchymal tissue masses was fortuitous, or related, could not be determined from this solitary case.

Adipose Tissue↗
PubMed1984

Ciliated hepatic foregut cyst.

This study describes a solitary unilocular cyst of the liver, lined by ciliated, pseudostratified, columnar epithelium supported by a loose, relatively acellular lamina propria. The cyst wall was composed of a prominent smooth muscle band, of up to three layers, surrounded by an outer fibrous capsule. These features distinguish the cyst from biliary cystadenoma and make it histologically similar to previously described ciliated bronchial and esophageal cysts. This ciliated hepatic cyst and similar bronchial and esophageal cysts appear to represent a common spectrum of derivatives from the embryonic foregut. Cysts of this type have not been generally recognized to occur in the liver.

Cysts↗
PubMed1983

Production of acute hemorrhagic pancreatitis in the dog using venom of the scorpion, Buthus quinquestriatus.

Acute hemorrhagic pancreatitis has been produced in dogs by two separate intraarterial injections (20 and 10 micrograms/kg) of venom from the scorpion Buthus quinquestriatus. Morphological changes related to the development of the disease were detectable by electron and light microscopy at 1 and 3 hr, respectively, following the injection of venom. Six hours following venom injection, widespread areas of hemorrhage and fat necrosis were observed on the surface of the pancreas and adjacent mesenteries. By 24 hr, areas of fat necrosis more than 1 cm in diameter were present on the surface of the pancreas. No free protease was found in pure pancreatic juice collected at 3, 6, 24, and 96 hr after the injection of Buthus quinquestriatus venom. Amylase concentrations in serum increased to a maximum sevenfold above the basal level at 6-8 hr after injection. Since acute hemorrhagic pancreatitis occurred both with and without pancreatic duct cannulation, it is likely that the pathological process is independent of any venom effect on papillary sphincter tone. The morphological characteristics of the experimental disease appear similar to those observed at autopsy in acute hemorrhagic pancreatitis in humans.

Acute Disease↗
PubMed1980

Fibrolamellar carcinoma of the liver: a tumor of adolescents and young adults with distinctive clinico-pathologic features.

Clinical and pathologic features of 23 patients with a distinctive histologic and clinical variant of hepatocellular carcinoma are summarized. The variant pattern of hepatocellular carcinoma is most common in the age group 5--35 years and occurs equally in either sex. The distinctive histologic features include 1) deeply eosinophilic neoplastic hepatocytes, many of which contain intracytoplasmic hyaline globules and distinct pale bodies and 2) fibrosis arranged in a lamellar fashion around the neoplastic hepatocytes. The histologic and gross features of the tumor have been confused both with focal nodular hyperplasia and with hepatocellular adenoma. The average survival of 32 months and the high operability rate of 48% far exceed the survival or operability for ordinary hepatocellular carcinoma. Thus, this tumor type must be recognized and considered separately when evaluating therapeutic results in large series of patients with hepatocellular carcinoma.

Adolescent↗
PubMed1980

An autopsy survey of clinical and anatomic diagnoses associated with alcoholism.

Alcoholism, a major cause of hospitalization and death in the United States, has been associated with multiple organ system dysfunctions. A systematic search by computer was made of the diagnoses in 35,579 autopsies performed from 1949 to 1972 at the Los Angeles County-University of Southern California Medical Center. Alcoholic and control cases (total, 8,186) were matched by age, sex, race, and appropriate date of death. Many major differences in diagnosis between the two groups were found. A fourfold increase in the annual frequency of alcoholism at autopsy was noted during the period under study. The mean age at death was ten years less in the alcoholism group compared with the total population submitted to autopsy. This survey supports the hypothesis that the clinical and autopsy diagnosis in alcoholic and nonalcoholic patients are significantly different in frequency.

Adult↗
PubMed1978

A mixed hamartoma of the liver: light and electron microscopy.

The gross, microscopic, and ultrastructural features of a mixed liver hamartoma occurring in a three month old infant are reported. The differentiation from two solid liver masses, focal nodular hyperplasia and liver cell adenoma is emphasized. Mesenchymal hamartomas, though usually cystic rather than solid masses, share the histologic feature of fibroductular tissue with mixed liver hamartomas and focal nodular hyperplasia. Only the mixed liver hamartoma has extremely broad fields of ductules and an embryonic type of hepatocyte at the ultrastructural level. These and other hepatic lesions show morphologic evidence of transformation of liver cells into biliary epithelial cells in association with vascular connective tissue.

Hamartoma↗
PubMed1977

Regression of liver cell adenomas associated with oral contraceptives.

The regression of liver cell adenomas that follow the use of oral contraceptives when steroids are withdrawn was observed in three patients. At diagnosis by needle biopsy in patients without pain or evidence of hemorrhage, prompt cessation of steriod use is suggested as the preferable form of treatment. The same is true for the diagnosis made at surgery if the tumor or tumors are difficult to remove.

Adenoma↗
PubMed1976

Liver-cell adenomas associated with use of oral contraceptives.

During the past six years an increasing number of liver-cell adenomas in women were diagnosed, and we undertook a study of possible etiologic factors, including use of oral contraceptives, in 42 women. There was a significant difference between cases and matched controls in mean months of oral-contraceptive use: 73.4 as compared to 36.2 (P less than 0.001). The women with adenomas took mestranol-containing pills much more commonly than the controls (P less than 0.0001). Hemorrhage into the tumor was often associated with the onset of menstruation in women taking oral contraceptives. Long-term use of oral contraceptives, especially those containing a high total dose of steroids or mestranol as the synthetic estrogen, should be balanced against risks of side effects of the drugs.

Adult↗