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Biomedical subjects

H A Ferrari

Publications and source records attributed to H A Ferrari.

11 recordsLinked to original sources

High-frequency jet ventilation: applications for endoscopy and surgery of the airway.

Twenty-four patients underwent endoscopic procedures under general anesthesia and mechanical ventilation by high-frequency jet ventilation, provided by a catheter inserted through the cricothyroid membrane and connected to an IDC-VS600 ventilator. The arterial blood gas values, arterial blood pressures, and heart rates observed were within acceptable clinical levels. In some patients, blockage of the airway by the surgeon required shutting off the ventilator to prevent a pneumothorax. With the rapid rate jet ventilation, we found that laryngeal bleeding after biopsy passed outward from the larynx into the hypopharynx. It was necessary for the surgeon to wear protective eye and face shielding when performing endoscopies to avoid getting blood and secretions on his face. The unobstructed surgical field is an advantage of the jet ventilation, which can be continued in the postoperative period until the patient is fully recovered.

Adult

Bleomycin increases superoxide anion generation by pig peripheral alveolar macrophages.

Pulmonary fibrosis is the major toxic effect of bleomycin chemotherapy; however, the molecular mechanisms of the pathological process are unknown. Since alveolar macrophages produce toxic oxygen metabolites and these can damage lung cells, the effect of bleomycin on superoxide anion production was investigated in subpopulations of pig alveolar macrophages. Cells were lavaged from the lung and separated into three subpopulations according to their density. Their capacity to generate superoxide anions increased the more distally they were located. Bleomycin (5.0 milliunits/ml) increased the rate of superoxide production by 75 +/- 24% in dense alveolar macrophages located in the lung periphery. Hydrocortisone (10.0 micrograms/ml) inhibited this superoxide production by 33 +/- 10%. Results from this study suggest that an excess production of superoxide anions by alveolar macrophages may be the underlying cause of bleomycin pulmonary toxicity.

Animals