Biomedical subjects
Publications and source records attributed to H A Freye.
The aim of the present study was to compare self-reported handedness with the directly tested hand preference using a 10-item battery in sample of 1223 students. The question assessing self-reported handedness was whether you are a left- or a right-hander or you use both hands equally. Responses indicate that self-reported handedness is a crude but possible method of measurement. Female right-handers showed the best agreement.
The aim of the present study was to investigate the relationship between handedness and hand clasping or arm folding. Our own investigations have shown no relationship as is consistent with most results in the literature which suggests only minor functional importance of these two signs of latent handedness.
The present knowledge concerning the possible prenatal effect of benzene and/or its metabolites is presented. Animal experimental results and epidemiological studies proved to be completely insufficient. The physical, chemical and biochemical properties of this ubiquitously occurring solvent, especially the specific effects on the erythropoetic system including the damage of the cyto skeleton of the cells, require an enhanced attention in the cases of exposure of female workers in child bearing age and of pregnant women to benzene, even in cases of surely observing the maximum allowable concentration at work places.
The incidence of multiplets according to Hellin is no more valid in the last years. The reasons have been discussed. Different comprehensions about the valence of the different methodic variants of twin research have been explained.
In 35 patients at the age between 20 and 45 years with a manifest coronary heart disease various lipid-chemical parameters were established and compared with a control group of the same age of laboratory-chemically and clinically inconspicuous test persons as well as with a group of patients with infarction older than 45 years. For HDL-cholesterol, LDL-cholesterol as well as LDL significant differences of the mean value were the result in the group of juvenile patients with a coronary heart disease and in the healthy control group as well as the group of older test persons with infarction, which confirm the accumulation of lipid-chemical risk constellations in "juvenile" patient with a coronary heart disease. Moreover, the proportion of primary hyperlipoproteinaemias is essentially greater in these patients than in older test persons with infarction. Apart from the recognition of primary hypercholesterolaemias the diagnostics of autosomally combined hyperlipoproteinaemias is of particular importance.
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The significance of genetic factors contributing to the complex etiology of coronary heart disease is discussed using lipoprotein metabolism as an example. A radiochemical screening method was developed fro precise biochemical diagnosis of autosomal monogenic hypercholesterolemia. In this method lymphocytes are used as test material.
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Apart from the determination of preporphyrin and porphyrin in the urine recently enzymatic methods entered the diagnostics of the acute intermittent porphyria. Of particular importance is the decrease of activity of the uroporphyrogen-1-synthetase in the manifest disease as well as in the clinically healthy carriers of genes. Since the clinical picture as well as the values of chemical laboratory examinations in the acute intermittent porphyria are extraordinarily variable, a long-term control of diagnostics and therapy is necessary.
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Explore the source record for details and available documents.