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Biomedical subjects

H A Ibrahim

Publications and source records attributed to H A Ibrahim.

12 recordsLinked to original sources
PubMed2001

Endoscopic-guided trephination dacryocystorhinostomy (Hesham DCR): technique and pilot trial.

OBJECTIVES: (1) Test the feasibility and the safety of guided transnasal trephination in creating a nasolacrimal fistula. (2) Develop an appropriate lacrimal maintainer and test its value in modulating healing at the fistula site. DESIGN: Prospective, noncomparative interventional case series. PARTICIPANTS: Five cadavers and 19 patients. METHOD: A transcanalicular lacrimal probe penetrated the lacrimal fossa to guide the passage of a flexible trephine up the nose, which created the nasolacrimal communication. A special wide-caliber lacrimal maintainer was inserted along lacrimal tubes within the created passage. OUTCOME MEASURES: For cadaveric study, direct inspection after dissection of the facial flap was performed. For the clinical trial, subjective improvement in watery eye, dye testing, lacrimal probing, lacrimal irrigation, and endoscopic nasal examination. RESULTS: The technique resulted in the creation of a regular fistula of reproducible diameter into which a standard-shaped wide caliber maintainer could be inserted. Three months after removal of the maintainer and 6 months after surgery, a patent ostium was achieved in 17 of 18 (94%) patients who had a completed procedure. Relief of symptoms was achieved in 83%. CONCLUSIONS: Guided endoscopic dacryocystorhinostomy provides a simple and safe option for the treatment of nasolacrimal duct obstruction. The lacrimal maintainer is a useful device to achieve a large patent nasolacrimal communication.

Adult↗
PubMed1999

Diabetic nephropathy.

Diabetic nephropathy remains a leading cause of end-stage renal disease (ESRD) in western societies, accounting for over one-third of all patients beginning renal replacement therapy. Patients with Type 2 diabetes comprise the largest and fastest-growing single disease group requiring renal support therapy. In addition to the high risk of progression to ESRD, diabetic nephropathy is associated with a very high risk of cardiovascular morbidity and mortality, which is not abolished by dialysis and renal transplantation. While the prognosis of patients with diabetic nephropathy has considerably improved, a greater focus has recently been placed on treating diabetic patients early in order to prevent future organ failure. Microalbuminuria is an important intermediary end-point that correlates strongly with future advanced renal disease and cardiovascular mortality. Recent evidence indicates that optimum glycaemic control, tight blood pressure control, and the regular screening for and early treatment of microalbuminuria are necessary to prevent the development and progression of diabetic renal disease. By utilizing such strategies, the challenge is to reduce the cumulative incidence of overt nephropathy, with its associated increase in cardiovascular mortality, and the requirement for renal support therapy. Over the next 5-10 years, the patient with Type 2 diabetes will need to be the specific focus of such preventive treatment modalities.

Albuminuria↗
PubMed1999

Should we routinely check for hepatitis B and C in patients with lichen planus or cutaneous vasculitis?

The study aimed to determine the prevalence of HBs-Ag and anti-HCV antibodies in a group of 43 patients with lichen planus and 19 patients with cutaneous vasculitis versus 30 controls. The results showed that 12 (27.9%) patients with lichen planus were positive for HBs-Ag, 9 (20.9%) were positive for anti-HCV antibodies and 3 (7%) were positive for both. In cutaneous vasculitis patients, 3 (15.8%) were HBs-Ag-positive, 7 (36.8%) were anti-HCV-positive and 3 (15.8%) were positive for both. In the control group, 8 (26.7%) were HBs-Ag positive, 3 (10%) were anti-HCV-positive and 1 (3.3%) was positive for both. These values were not statistically significant.

Adolescent↗
PubMed1993

Scanning electron microscope observations on the digenean intestinal parasite Astiotrema reniferum (Plagiorchiidae).

The body surface of adult digenean intestinal parasite Astiotrema reinferum (Looss, 1898) Stossich, 1904 has been studied using scanning electron microscopy (SEM). The posterior region of the body forms a slender stalk terminating with two ventrolateral lobes. The lobes are armed with numerous large spine that are sharply pointed and orientated in all directions. There are regional variations in the distribution of spines all-over the body. The spines are abundant on the general body surface of the head region, the rim of the oral sucker, the inner lip of the ventral sucker and on the posterior ventrolateral lobes. No spines were observed on the genital pore and on the excretory opening. The sensory papillae found on both the oral and ventral suckers are arranged in a bilateral symmetrical patterns. They are dome shaped but some of them possess a short knob-like process and others have no process. The papillae are more abundant on the oral sucker than on the ventral sucker. The possible functions of the spines and sensory papillae are discussed relative to their position.

Animals↗
PubMed1990

Growth of rats during a subchronic intake of the heavy metals Pb, Cd, Zn, Mn, Cu, Hg, and Be.

Adult female SPF Sprague-Dawley rats were given 100 ppm Pb (CH3COO)2, CdCl2, MnCl2, ZnSO4, CuCl, Hg2(NO3)2, or BeSO4 for 91 days with their drinking water. The body weight gain of the rats changed during the 91 days of continuous inclusion of the heavy metal salts. During examination, body weights increased after the daily intake of MnCl2, ZnSO4 or BeSO4, but the other salts of Pb, Cd, Cu, Hg decreased the body weights, each compared with the controls. These effects were possibly caused by changes in feeding and drinking habits: The daily consumption of standard diet (pellets) increased during dosing with the salts of Mn, Zn or Be and decreased during treatment with the other heavy metal salts. The salts of Be and Mn enhanced consumption of drinking water, and the salts of Zn, Pb, Cu, Cd or Hg reduced consumption of drinking water, each compared with the controls. Most effective was Hg2(NO3)2. Perhaps, the heavy metal salts cause a change in the regulation of the appetite in the central nervous system.

Animals↗
PubMed1988

Effect of soybean feeding on experimental carcinogenesis--III. Carcinogenecity of nitrite and dibutylamine in mice: a histopathological study.

The potential carcinogenic effect of nitrosamine precursors, DBA (dibutylamine) and nitrite, was clearly demonstrated pathologically in the liver and bladder of male Swiss albino mice. Benign tumours were induced in the bladder with an incidence of 40%, and hepatomas were detected in the liver in 27% of the cases. The protective effect of soybean and ascorbic acid, added separately to the diet or to the drinking water respectively, was demonstrated by a marked reduction in dysplastic features and absence of tumour in both the liver and the urinary bladder.

Animals↗
PubMedDate not supplied

Responding to the challenge of diabetic nephropathy: the historic evolution of detection, prevention and management.

Diabetic nephropathy remains a leading cause of end-stage renal disease (ESRD) in western societies, accounting for about 40% of all patients beginning renal replacement therapy. Patients with type 2 diabetes comprise the largest and fastest growing single disease group requiring renal replacement therapy. In addition to the high risk of progression to ESRD, diabetic nephropathy is associated with a very high risk of cardiovascular (CV) morbidity and mortality, which is not abolished by dialysis or renal transplantation. Over the past two decades there have been major advances in our attempts to understand the risk factors for development and progression of diabetic renal dysfunction, that have resulted in better characterisation of the natural history of this serious complication. Effective antihypertensive treatment and aggressive management of CV risk factors have helped improve the prognosis of patients with overt diabetic nephropathy, particularly those with type 1 diabetes. However, for the larger proportion of patients with type 2 diabetes, the renal and CV prognoses are still poor. Recently, more focus has been placed on treating diabetic patients early in order to prevent future organ damage. Microalbuminuria is an important intermediary end-point that correlates strongly with CV mortality in all people with diabetes as well as progression to ESRD in people with type 1 diabetes. We can now identify patients at high risk early in the natural history of their disease. Clinical trials have uniformly shown that in the early disease history of diabetes, achievement of both tight glucose control, eg, HbA1c <7%, and tight blood pressure control eg, blood pressure <140/80 mm Hg, substantially reduces CV events and progression of nephropathy. In latter stages of diabetes, tight blood pressure control has a relatively greater impact on CV risk reduction as compared to tight glucose control. The challenge for the practising physician, however, is to maximally utilise the available modalities of treatment to prevent progression to overt nephropathy and reduce the associated high risk of CV morbidity and mortality. In the early 21st century, the patient with type 2 diabetes will need to be the specific focus for use of these preventive treatment modalities due to the geometric risk in the international incidence of this disease.

Diabetic Nephropathies↗
PubMedDate not supplied

Am empirical study of selected cost measures of clinical engineering service effectiveness.

The growing demand for more and better healthcare service greatly expands the role of medical equipment in providing health services more effectively. The purpose of introducing clinical engineering programs in hospitals was to improve the effectiveness of healthcare institutions' utilization and management of medical technology. Over the last decade, the role of clinical engineering has grown in importance as a component of hospitals and the healthcare delivery system. Hospital administrators currently put a strong emphasis on cost effectiveness of clinical engineering services, to reduce the cost of acquisition and maintenance of equipment. Unfortunately, the lack of a commonly accepted definition of cost effectiveness has resulted in a certain amount of confusion over how the performance of clinical engineering services can or should be measured. The results presented in this paper should assist hospital administrators and clinical engineering program managers to establish a common understanding of what "cost effectiveness" means and how it can be achieved.

Biomedical Engineering↗
PubMedDate not supplied

Endonasal laser dacryocystorhinostomy and external dacryocystorhinostomy outcome profile in a general ophthalmic service unit: a comparative retrospective study.

PURPOSE: To evaluate the outcome profile of endonasal laser dacryocystorhinostomy (ENL-DCR) in comparison with external dacryocystorhinostomy (ENL-DCR) carried out as part of general ophthalmic service within the same center. METHODS: Patients who have undergone external or endonasal laser DCR in the authors institute with a minimum follow-up of 9 months and at least 3 months after removal of the tubes were invited to participate in this research. We used a questionnaire and a systematic clinical examination for detecting lacrimal passage patency and function. Patients were classified into categories: complete anatomical and physiological success; anatomical success with partial relief of symptoms; anatomical success with no relief of symptoms; anatomical failure. The endoscopic view of the ostium vertical location has been classified into four levels. RESULTS: One hundred and ten external-DCR and 53 Endonasal-DCR procedures were evaluated. Free communication (anatomical success) was achieved in 82% undergoing Ext-DCR and in 58% undergoing ENL-DCR. A significant number of patients continued to have symptoms in spite of a patent fistula (54% for Ext-DCR and 39% for ENL-DCR). The site of the opening of the internal ostium was significantly related to the persistence of symptoms in spite of free communication (P < 0.001, chi-square test). CONCLUSION: In this series of patients undergoing DCR in a general ophthalmic unit, the standard Ext-DCR technique has a higher anatomical success rate than the endoscopic laser DCR but not necessarily with equivalent rate of relief of symptoms. An inferiorly placed ostium is more likely to result in complete relief of symptoms.

Adult↗
PubMedDate not supplied

Suitability of soluble transferrin receptor for the clinical diagnosis of different types of anaemia in children.

We evaluated the ability of serum transferrin receptor (sTFR) to identify different types of anaemia in children. Thus 150 Egyptian children suffering from anaemia (iron deficiency anaemia, anaemia of chronic disease and beta-thalassaemia) were enrolled, together with 50 controls. There was a significant increase in the mean levels of sTFR in the groups with iron deficiency anaemia and thalassaemia, and a significant decrease in mean sTFR levels in the group with anaemia of chronic disease. Serum ferritin levels were significantly higher in all patient groups except the group with iron deficiency anaemia. There were also significant correlations between the sTFR and sTFR/log ferritin ratio (sTFR-F index) and different indices of iron status and of erythropoiesis. The sTFR-F index could be used as a diagnostic or screening tool for iron deficiency anaemia, anaemia of chronic disease and thalassaemia.

Adolescent↗