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Biomedical subjects

H A Larkin

Publications and source records attributed to H A Larkin.

8 recordsLinked to original sources
PubMed1996

Gentamicin-induced nephrotoxicosis in lambs.

Lambs injected with gentamicin sulphate remained bright and continued to eat, but their plasma creatinine and urinary microprotein concentrations and activities of alkaline phosphatase, gamma glutamyltransferase, leucine aminopeptidase, and N-acetyl-beta-glucosaminidase were significantly increased. Urinary creatinine and specific gravity were significantly decreased. The kidneys of lambs killed shortly after the last treatment with gentamicin were pale and oedematous and microscopic changes included marked tubular necrosis and dilation. Mild tubular dilation was the only lesion in lambs killed later. Reduced enzyme activity was observed histochemically in cells of the convoluted tubules. The lambs showed little clinical evidence of gentamicin toxicity, but the urinary enzyme activity and protein content were sensitive and reliable markers of renal injury, in agreement with the pathological findings. The lesions were different from those reported in naturally occurring tubular nephrosis of lambs.

Animals↗
PubMed1985

Gastrointestinal flora in iron-deficient piglets.

The pH and microflora of the contents of the stomach and small intestine were studied in iron-treated and iron-deficient piglets. Compared with their iron-treated littermates, the gut contents at several sites in iron-deficient animals had a higher pH and contained greater numbers of coliforms, lactobacilli, total aerobes and total anaerobes. The possible relationship of these findings to previous findings in such animals and to their high incidence of diarrhoea is discussed.

Anemia, Hypochromic↗
PubMed1984

Intestinal absorption and structure in iron deficient piglets.

Absorption of D xylose by iron deficient piglets from three litters was as rapid as in their iron treated littermates, except when they were affected by diarrhoea. The dry matter content of the faeces of iron deficient piglets was marginally decreased, but the fat content of the faeces was significantly increased in two tests out of four. Diarrhoea in iron deprived piglets was associated with a small decrease in dry matter content and a large increase in fat content of the dry matter of the faeces and in fat excreted per kg bodyweight. Frank villous atrophy was evident histologically in iron deficient piglets which had diarrhoea when they were killed. Morphometric analysis of small intestinal specimens showed a significant decrease in villous length, villus-to-crypt ratio and mucosal complexity among iron deficient piglets. Crypt depth was not reduced.

Animals↗
PubMed1983

Gastric structure and function in iron-deficient piglets.

Gastric motility, secretion and structure were studied in piglets which were weaned at two weeks of age and reared in iron-free cages on a low-iron diet. Piglets which were not given iron parenterally rapidly developed iron deficiency anaemia. Gastric motility was studied fluoroscopically after dosing the piglets with barium sulphate. Gastric secretion was studied in piglets with gastric cannulae after stimulation with betazole hydrochloride. There was no difference between iron-treated and iron-deprived pigs in the motility of the stomach but in iron-deprived animals there was marked impairment of acid and chloride secretion from an early age and histological evidence of atrophic gastritis.

Anemia, Hypochromic↗