[Absence of native anti-DNA antibodies in chronic active hepatitis].
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Autoantibodies↗
Biomedical subjects
H A Menard
Publications and source records attributed to H A Menard.
Trace elements and acute phase reactants in gold treated rheumatoid arthritis patients.
Abnormal concentrations of trace elements, sulfhydryl groups, amino-acids and serum proteins were found in patients with rheumatoid arthritis similar to other chronic inflammatory conditions. These changes have been called the phase reaction. In this study, a systematic profile of the phase reactants was established in rheumatoid arthritis at the onset and during its modulation by chrysotherapy (gold sodium thiomalate 25 mg i.m. weekly). It was shown that this treatment, if successful, is capable of reverting to normal measures of the phase reaction. It was also found that the pattern of the profile varied in individuhe eventual beneficial or toxic effects. In these preliminary studies, no parameters or group of parameters of the phase reaction were predictive of the therapeutic outcome. Extended observations (over 6 months) and more individual profiles are being analyzed to gain insight into these features of inflammation and their modulation by chrysotherapy.
Adult↗
Trace element determination in serum by proton-induced x-ray emission.
We report the use of proton-induced x-ray emission (PIXE) as an analytical method in clinical research. The experimental set-up and target preparation procedures are briefly discussed together with the methods of automatic data acquisition and analysis. Results from a clinical project involving rheumatoid patients receiving chrysotherapy are presented.
Arthritis, Rheumatoid↗
Antinuclear antibody: predictive of lymphocyte response in rheumatoid arthritis.
The phytohemagglutinin induced response of lymphocytes was studied in two groups of rheumatoid patients differing only in the presence or absence of antinuclear antibodies (ANA). The response was found to be depressed in 16 ANA positive and normal in 14 ANA negative patients. Antinuclear antibody screening may serve as a simple method to identify a subgroup of immunodepressed rheumatoid patients who may be potential candidates for immunostimulation therapy.
Antibodies, Antinuclear↗
[Scleroderma: what is it].
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Fibroblasts↗
Experimental immune arthritis: host factors.
An experimental chronic mono-arthritis was induced in rabbits using adjuvants and bovine serum albumin. The results suggest that unidentified host factors (possibly genetic) influence the induction of delayed hypersensitivity to the antigen. The data further show a clear correlation between systemic cell mediated immunity and chronic synovitis. When this condition is absent, there is a poor correlation between the humoral response and the arthritis. The results make difficult the interpretation of local immune complex deposition as the sole, chronic phlogistic stimulus. (J Rheumatol 2: 373-383, 1975).
Adjuvants, Immunologic↗
Slow onset anti-rheumatic drugs in rheumatoid arthritis: could the presence of antinuclear antibody influence the therapeutic results?
The therapeutic value of sodium aurothiomalate, D-penicillamine and levamisole was evaluated in three comparable groups of 20 rheumatoid arthritis (RA) patients. There was no intergroup difference after a 3-month follow-up and all were significantly improved (p less than 0.001). To verify if, in these patients, the presence of antinuclear antibodies (ANA) had influenced the therapeutic results, each group was retrospectively subdivided according to the ANA status. To start with, all the sub-groups were statistically comparable on the basis of measures of disease activity. The D-penicillamine group could not be analyzed. In the gold treated group, the ANA negative patients were more improved than the ANA positive (p = 0.03), and very significantly more than the levamisole-treated ANA-negative patients (p = 0.005). The ANA negative patients taking levamisole had less pain relief (p = 0.01) and showed a tendency for less overall improvement (p = 0.15) than the ANA positive patients. This preliminary study supports the idea that systematic ANA testing in RA may be of practical and theoretical value.
Anti-Inflammatory Agents↗