Biomedical subjects

H A Moses

Publications and source records attributed to H A Moses.

13 recordsLinked to original sources

PubMed1979

Trace elements: an association with cardiovascular diseases and hypertension.

Abnormalities associated with trace elements have not received much attention from clinicians in the past; however, in the past few years there has been a veritable explosion of knowledge about trace elements which are associated with abnormalities in experimental animals as well as in humans. The information explosion is rapidly reaching the stage where clinicians will be called upon more frequently to diagnose and treat trace element-related maladies.This article introduces to the clinician some pertinent relationships between several of the more common trace elements and their suspected relationship with cardiovascular diseases and hypertension.

Animals↗

PubMed1979

Cadmium: hypertension induction and lead mobilization.

In recent years interest has increased in the study of the metabolism of cadmium because of its presence in the environment as a toxic agent. Having no known essential bodily functions and possibly altering the action of various other trace metals, eg, lead and zinc, cadmium has been suspect as a causative factor in certain pathological alterations, such as hypertension. A study of this association was undertaken by the authors.Female Sprague-Dawley rats were fed laboratory chow and given cadmium nitrate ad libitum. Systolic pressure was monitored and weights were recorded at weekly intervals. Cadmium and lead were determined in kidney and liver tissues of the sacrificed animals by using a trace metal analyzer and by atomic absorption spectrophotometer. After 36 weeks on the experimental regimen, the cadmium-treated animals had higher systolic pressures than the control group (155 ± 10 mmHg compared to 96 ± 5 mmHg). Increased levels of cadmium reflective of the cadmium consumed were found to occur in liver and kidney tissues. The urinary excretion of deltaaminolevulenic acid by the experimental animals was higher than that of the control animals. This suggests that the supplemented cadmium induced lead to leave the kidney and become metabolically active.

Animals↗

PubMed1976