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H A SCHROEDER

Publications and source records attributed to H A SCHROEDER.

88 records · Page 5Linked to original sources
PubMed1950

Pressor substances in arterial hypertension. II. Demonstration of pherentasin, a vasoactive material procured from blood.

Pherentasin, a highly active pressor substance producing a prolonged effect in the rat, has been obtained in a fairly pure form from the arterial blood of patients with hypertension. Its presence has been demonstrated by two biological methods. It was rarely found in normotensive blood. The blood of patients with renal or nephrogenic hypertension, either primary or secondary, consistently yielded this material. The blood of patients exhibiting neurogenic hypertension and the endocrine hypertensive syndrome had smaller amounts of it. Little or none was found in malignant hypertension. Perhaps pherentasin has a causal relation to the existence of arterial hypertension.

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PubMed1950

Pressor substances in arterial hypertension. III. Chemical studies on pherentasin.

Pherentasin, a material producing a prolonged pressor response in rats, has been procured from the arterial blood of hypertensive patients and purified. Pherentasin is of small molecular size, non-protein in nature, dialyzable, soluble in water and 90 per cent ethanol, and extractable into organic solvents from alkaline solution. It contains an amino group essential to activity, which is probably primary, and also contains an active carbonyl group. It has been found in concentrations up to approximately 20 gamma per liter of blood.

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