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Biomedical subjects

H A Stone

Publications and source records attributed to H A Stone.

27 records · Page 2Linked to original sources
PubMed1967

Two loci controlling genetic cellular resistance to avian leukosis-sarcoma viruses.

Female chickens known to be heterozygous for resistance to subgroups A and B of the avian leukosis-sarcoma viruses were mated to males known to be homozygously resistant to both. The progeny were assayed both on the chorioallantoic membrane (CAM) and in tissue culture for resistance to representative viruses of the A, B, and tentatively defined C subgroups. Segregation ratios of resistance to A and B subgroup viruses agreed with the previously suggested hypothesis of single-autosomal-recessive genes controlling resistance to each subgroup. Mixed infection on the CAM and replicate plate infection in tissue culture with subgroup A and B viruses showed that resistance to the A and B subgroups was inherited independently. Assays with viruses tentatively classified as subgroup C indicated that they were largely composed of a mixture of subgroup A and B viruses or of particles possessing the host range specificity of both. However, virus stocks of the subgroup C category, as well as some stocks classified as subgroup B, produced small numbers of pocks or foci on individuals known to be resistant to subgroup A and B viruses. It is suggested that these Rous sarcoma virus stocks carry between 1 and 10% of a true subgroup C virus.

Alpharetrovirus↗
PubMedDate not supplied

Cortical screws versus absorbable pins for fixation of the short Z-bunionectomy.

Fifty-four Z-bunionectomies were performed on 43 patients. Twenty-nine osteotomies were fixated with Orthosorb pins, and 25 were fixated with a single 2.7-mm. cortical screw. Postoperative pain, edema, bone callus, and complications were evaluated for each fixation method. All patients were followed for more than 1 year. The incidence of metatarsal head dorsiflexion in screw fixated osteotomies was double that of Orthosorb. Radiographic evidence of pin tracts persisted beyond 1 year in about half the Orthosorb fixated osteotomies. The authors conclude that in properly selected patients, Orthosorb is as effective as a screw in fixating the osteotomy.

Adolescent↗
PubMedDate not supplied

L-osteotomy with absorbable fixation for correction of tailor's bunion.

A procedure is described for correction of tailor's bunions. The L-osteotomy is a transpositional neck osteotomy that is inherently stable. Fixation of choice is the Orthosorb absorbable pin (Johnson & Johnson Orthopedics, Raynham, MA). A retrospective study was undertaken of 12 patients who underwent 21 osteotomies. All patients believed that the pain and deformity associated with the tailor's bunion were resolved by the surgery. One asymptomatic nonunion, and one asymptomatic malunion occurred. At final follow-up, radiographic lucency at the Orthosorb pin sites persisted in 62% of the feet.

Adolescent↗
PubMedDate not supplied

Epigard: a synthetic skin substitute with application to podiatric wound management.

The authors present a synthetic skin substitute, Epigard, which was developed in 1973 and has been used worldwide for temporary coverage of open wounds. Epigard is a two-layer, non-medicated wound dressing which approximates the function of human skin. The article discusses the proper indications and usage of Epigard, as well as post operative wound management and definitive wound closure decisions. A case presentation involving a serious diabetic wound infection is discussed. At Doctors Hospital, Epigard has become an important adjunctive therapy in wound management by improving wound healing time and decreasing patient hospital stay.

Debridement↗