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H A Tiddens

Publications and source records attributed to H A Tiddens.

34 records · Page 2Linked to original sources
PubMed1995

Cartilaginous airway dimensions and airflow obstruction in human lungs.

Airway wall remodeling in asthma and chronic obstructive pulmonary disease (COPD) can have a profound effect on the function of the airways. We tested the hypothesis that airflow obstruction and estimates of peripheral airway inflammation correlate with airway wall thickness and the amount of bronchial smooth muscle in cartilaginous airways. In addition, we estimated the theoretical relation between airway dimensions and airway resistance with a computational model. Lung tissue was obtained from 72 patients with different degrees of COPD who were operated on for a solitary peripheral lung lesion. In 341 transversely cut cartilaginous airway sections we measured airway size and airway wall dimensions. Inflammatory changes from the same lungs were scored in noncartilaginous airways. Preoperatively measured maximum expiratory flows and the response to a bronchodilator were correlated with airway wall dimensions. Maximum expiratory flow, the reversibility of airflow obstruction, and peripheral airway inflammation were significantly related to the airway wall area but not to the smooth muscle area. We conclude that airflow obstruction and its reversibility in COPD is in part caused by thickening of the cartilaginous airway wall and is related to inflammatory changes.

Airway Resistance↗
PubMed1993

Juvenile-onset mixed connective tissue disease: longitudinal follow-up.

To establish the symptoms and clinical course of juvenile-onset mixed connective tissue disease, we studied 14 patients, classified according the criteria of Kasukawa et al. The patient records were studied retrospectively and all patients were examined in a 1-day follow-up program. Systemic lupus erythematosus and polymyositis/dermatomyositis-like symptoms disappeared in time, whereas scleroderma-like symptoms (such as in the Raynaud phenomenon) and joint abnormalities persisted. Extensive limitation of joint function was found in four patients. At the time of follow-up, no active renal disease was found. Thrombocytopenia was still present in one of the three patients who had had this feature. All patients had abnormalities of esophageal motility. Long-term corticosteroid treatment was associated with aseptic bone necrosis in three patients and growth retardation in one. We conclude that the Kasukawa criteria are easy to apply to children, and that juvenile-onset mixed connective tissue disease has many similarities to the adult form of the disease.

Adolescent↗
PubMed1991

[Juvenile dermatomyositis, systemic lupus erythematosus and mixed connective tissue disease].

This paper covers the current insights into the classification, etiology, management and prognosis of juvenile dermatomyositis (JDMS) systemic lupus erythematosus (SLE) and mixed connective tissue disease (MCTD). Since specific diagnostic tests for these autoimmune diseases are not available, diagnosis depends on the presence of defined criteria. Drug therapy in JDMS consists of prednisone at a low dosage (1 mg/kg/day). In SLE different therapeutic approaches are known depending on the occurrence of life threatening symptoms. The prognosis of MCTD is good, it is of prime importance to avoid overdosage of corticosteroids, since drug treatment is often not needed.

Adrenal Cortex Hormones↗
PubMed1979

Haemolytic uraemic syndrome.

The haemolytic uraemic syndrome is an acute illness characterised by the occurrence of renal injury, haemolytic anaemia with red cell fragmentation and thrombocytopenia. Haemorrhagic diathesis, arterial hypertension and neurological manifestations often complicate the acute phase of the disease. In this article, we shall discuss in more detail the aspects of this phase. Data obtained in 72 patients treated at the Wilhelmina Children's Hospital in Utrecht, from 1964 to 1977, are used to illustrate the characteristics of the disease.

Acute Kidney Injury↗
PubMed1976

Measurement of intravesical and rectal pressures simultaneously with electromyography of anal sphincter in children with myelomeningocele.

This paper reports a technique for simultaneous measurement of intravesical pressure, intra-abdominal pressure, electromyographic activity of the external and sphincter and urinary flow. Using this technique during filling of the bladder and during micturition in 38 children with myelomeningocele and neurogenic bladder disturbance, it was possible to identify four main types of bladder dysfunction in these children. Once the type of bladder dysfunction is established for each child, adequate management can be planned far in advance of the detection of inherent upper urinary tract damage. This is particularly important in children with upper somatomotor lesions of bladder innervation in which detrusor-spincter dyssynergia may be present; this dyssynergia always causes some degree of obstruction at the level of the external urethral sphincter and is a constant threat to renal function.

Abdomen↗