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Biomedical subjects

H Aagaard

Publications and source records attributed to H Aagaard.

14 recordsLinked to original sources
PubMed1999

Reduced degenerative articular cartilage changes after meniscal allograft transplantation in sheep.

The objective of this study was to examine the gross changes after meniscal allograft transplantation with reference to the development of degenerative articular cartilage changes (DACC) and to examine the transplant behavior. The medial menisci of both knees in 32 Iceland sheep were operated on with either sham operation (C6), medial meniscectomy (M6), primary transplantation (P6), or secondary transplantation 3 months after meniscectomy (S6). These sheep were observed for 6 months. Another six sheep were observed for 3 months after meniscectomy (M3) and contralateral sham operation (C3). The DACC of the knee were visualized with an intra-articular toluidine blue injection. The dissemination area of DACC on the medial tibial plateau (MTP), the meniscal area, and the meniscus-free, exposed central area on the MTP were measured by computer image analysis based on digitized photos of the tibial plateau. These area measurements were calculated relative to the area of the MTP. The DACC in P6 knees had a mean of 4.3%, which was less than the 12.6% in M6 (P < 0.001) and the 16.1% in S6 (P < 0.001), but more pronounced than the 0.5% in C6 (P < 0.005). There were no detectable differences in DACC between M6, S6 and M3 (16.9%). The measurements of DACC were reproducible with correlation coefficient r = 0.97 on intra-tester test-retest measurements. The area of the free exposed MTP was larger in P6 and in S6 than in C6 (P < 0.001), demonstrating a displacement of the graft. S6 transplants showed shrinkage and were smaller than C6 menisci (P < 0.01). In conclusion, primary meniscal allograft transplantation reduced DACC within 6 months in sheep knees, but DACC were still present in transplanted knees. The meniscal transplants demonstrated peripheral displacement.

Animals↗
PubMed1999

EMG activity of the iliopsoas muscle and leg kinetics during the soccer place kick.

The purpose of the study was to develop a method to record intramuscular electromyogram (EMG) from the iliopsoas muscle and to relate this activity to the kinetics during the soccer place kick. Seven skilled soccer players performed 3 maximal velocity place kicks. The kicks were filmed with a high-speed camera (400 Hz) and EMG recordings were obtained from 5 muscles of the kicking leg, including wire electrodes inserted into the m. iliopsoas. The EMG signals were compared to the kinetics of the kicking leg, which were calculated from the digitised film. The results showed hardly any torque reversal about the hip joint before impact. Angular deceleration of the thigh segment did not increase the angular velocity of the shank (work -3.57 to 0.0%). M. iliopsoas was active during the entire kicking motion (average EMG 65.1-100.9%), even in the period when the thigh was decelerating. Wire electrodes can successfully be applied to EMG recordings of fast unloaded movements.

Adult↗
PubMed1999

Function of the normal meniscus and consequences of meniscal resection.

The principal functions of the meniscus are load transmission and shock absorption, based on the meniscal collagen architecture, the biochemical fluid composition, and the proteoglucan-collagen meshwork. The mobile menisci transmit 50-90% of load over the knee joint, depending on knee flexion angle, femoral translation and rotation. The meniscus contributes to knee joint proprioception and probably also to joint stability. Late consequences of total and partial meniscectomy are radiographic osteoarthritis, with a varying percentage of these patients having symptoms. Malalignment, concomitant articular cartilage lesions, and ligament instability are absolute risk factors, while age, lateral compartment, and continued sport activity are relative risk factors. Acute reinsertion of meniscal tears in the red-red or red-white zones can be performed successfully by arthroscopic technique. Also in chronic tears stable healing can be expected in most cases, if the scar tissue is resected.

Animals↗
PubMed1999

Meniscal substitutes--animal experience.

Animal studies have shown that meniscus allografts and tendon autografts generally heal to the capsule, are revascularized and repopulated with host cells. In animals, neither meniscal allografts nor tendon or fat autografts gain the properties of a normal meniscus. Meniscus allografts and tendon autografts are promising as both seem to offer some protection to the cartilage of the tibial plateau. There is no evidence that meniscal transplantation can prevent cartilage degenerative changes, and the long-term effect of meniscal transplantation on articular cartilage remains unknown. Whether cellular repopulation of the meniscal allograft is sufficient to restore its biomechanical properties is unknown. Collagen scaffolds and tissue engineered grafts are still under investigation, showing promising results especially for the former. Viable meniscal allografts should be implanted within 1 to 2 weeks after harvesting, as the production of proteoglycans decreases after 2 weeks.

Animals↗
PubMed1999

Postoperative follow-up and rehabilitation after meniscus replacement.

Even though basic scientific knowledge about the meniscal loading pattern may advocate restrictive rehabilitation after meniscus repair, experience and one controlled study favour accelerated rehabilitation. The current protocols for rehabilitation after meniscal substitution follow personal experience with parameters such as pain, effusion, locking, and gait pattern used as clinical guidance. Controlled clinical studies on rehabilitation should be encouraged. An example of a rehabilitation protocol is given. As meniscus replacement is a new treatment option, it is essential to document details about the graft, the knee status at operation and the surgical procedure. The goal of a postoperative follow-up is to control quality, to measure patient satisfaction and to show whether meniscus replacement is beneficial in relation to the natural history of meniscectomy cases. There is a need for a standard follow-up evaluation of patients after meniscus replacement, and the development of a meniscus transplantation score including subjective and objective data is suggested.

Humans↗
PubMed1997

An epidemiological analysis of the injury pattern in indoor and in beach volleyball.

This study was designed to evaluate the injuries in indoor and in beach volleyball, and to compare the injury pattern in the two different types of volleyball. Injuries in 295 volleyball players were recorded during the beach volleyball season 1993 and during the following indoor volleyball season 1993 to 1994. The method of enquiry was two identical questionnaires. Equal numbers of men and women, elite and recreational players were represented. In beach volleyball 24 injuries were reported and 286 in indoor volleyball, representing an incidence of 4.9 injuries per 1000 volleyball hours in beach volleyball and 4.2 in indoor volleyball. The most frequent injuries were acute injuries located in the ankle and finger and overuse injuries in the knee and shoulder. The injury pattern was different in indoor and in beach volleyball. In beach volleyball most injuries occurred in field defence and in spiking, with overuse injuries in the shoulder as the major site. In indoor volleyball most injuries occurred during blocking and spiking, resulting most frequently in acute finger and ankle injuries, respectively.

Adult↗
PubMed1996

Injuries in elite volleyball.

During the 1993-1994 volleyball season, injuries to players in the two Danish elite divisions were registered by means of a questionnaire survey. Eighty per cent of the players returned the questionnaire. A total of 70 female players reported 79 injuries and 67 male players reported 98 injuries, representing an overall incidence of 3.8 injuries per player per 1000 volleyball hours played. The injury incidence was the same for female and male players. Most injuries occurred in spiking (32%) and in blocking (28%). The injuries were predominantly either acute injuries to fingers (21%) and ankles (18%) or overuse injuries to shoulders (15%) and knees (16%). Shoulder injuries seemed to be a more serious problem in females. During the past 10 years the rate of overuse injuries has increased from 16% to 47% in male elite volleyball, corresponding to a significant increase in the incidence of these injuries from 0.5 to 1.8 injuries per player per 1000 played hours (P < 0.001). A possible explanation for this could be a 50% increase in training activity during this period.

Adolescent↗
PubMed1996

Platinum-based cytotoxic therapy in basal cell carcinoma--a review of the literature.

Systemic cytotoxic therapy with platinum containing regimens has been reviewed in 53 patients with progressive disease of basal cell carcinoma. The overall response rate in 46 evaluable patients was 83% with complete remission obtained in 17 patients (37%), and partial remission in 21 patients (46%). Eight patients (17%) did not respond to platinum containing therapy. The median observation time was 26 months and the median time to progression 24 months. The median number of courses was 3 (range 2 to 12), and objective response was seen after median 2 courses (range 1 to 6). Platinum-based systemic chemotherapy, either alone or in combination with other therapeutic modalities, may be indicated as treatment of basal cell carcinoma when local therapy is inadequate, or in the rare cases with advanced lesions or metastatic disease.

Antineoplastic Agents↗
PubMed1995

[Antibiotic prophylaxis in Danish orthopedic alloplastic surgery].

In order to assess the routine use of prophylactic antibiotics (AB) in arthroplastic surgery in Denmark, questionnaires were sent to all Danish orthopaedic departments and all general surgical departments that perform orthopaedic surgery. Fifty-six departments (93%) returned the questionnaires. All departments use prophylactic AB in primary knee and hip arthroplasty and in revision arthroplasty. In addition, all departments but one use prophylactic AB in arthroplasty secondary to osteosynthesis. The largest group of departments uses penicillinase-resistant penicillin (PRP) in their standard prophylaxis regimens. The second largest group uses second generation cephalosporins. With one exception, all use cefuroxime. A small group uses other types of AB. Fifteen percent of the departments combine systemic AB with gentamicin bone cement (GC) in primary hip arthroplasty, whereas 22% use this combination in primary knee arthroplasty. Significantly more departments use GC in revision arthroplasty (89%) and in arthroplasty secondary to osteosynthesis (63%). Prolonged antibiotic prophylaxis (beyond 24 hours) is practised to a significantly higher degree in revision arthroplastic surgery than in the primary arthroplasties. In conclusion, one of two homogeneous groups of prophylactic AB is used in arthroplastic surgery in Denmark as prescribed in the literature.

Anti-Bacterial Agents↗
PubMed1994

Computer registration of infections used to measure the effect of prophylactic antibiotics on postoperative infections following osteosynthesis in hip fractures.

Continuous registration of operations and wound infections was used to demonstrate the effect of prophylactic antibiotics in hip fracture osteosynthesis. In order to monitor wound infections and other postoperative complications in an orthopaedic department, 2 years' data on 688 patients with hip fractures, were entered into a personal computer program. During 1990, there was no formal policy for antibiotic prophylaxis; during 1991 prophylactic cefuroxime was recommended for osteosynthesis of hip fractures. In 1990 56% of patients were given prophylaxis and in 1991 this rose to 79%. Overall, 68% of patients had prophylaxis. The overall rate of deep wound infections (DWI) was significantly lower in patients treated with prophylactic antibiotics (0.6%), compared with those without prophylaxis (4.6%). Patients with DWI were admitted to the hospital for an average of 43.7 days, compared with 14.6 days for patients without complications. We recommend the use of prophylactic cefuroxime in hip fracture osteosynthesis. Computer registration of complications is a useful method for clinical quality control in an orthopaedic department.

Adolescent↗
PubMed1989

Sickness absenteeism in an engineering industry--an analysis with special reference to absence for neck and upper extremity symptoms.

Neck and upper extremity symptoms (NES) are reported to increase among industrial workers. In order to quantify sickness absenteeism and relate it to some factors a questionnaire study was performed among 2,814 workers occupied at a Swedish engineering industry. Questions pertaining to age, sex, worker category, work with vibrating handtools, type of job and smoking habits were analyzed and correlated to sickness absenteeism for the previous year (1983). We found that the average days lost for personal illness was 17.2 days; 16.2 for men and 23.5 days for women. Ninety-four persons, 77 men and 17 women comprising 3.0% of all employees were sicklisted for NES corresponding to 3.3% of total sickness time lost. Blue-collar workers were sicklisted for NES five times more often than white collar workers and women in type 3 jobs (high NE stress), twice that of men occupied in the same type of job. Smokers had significantly higher absenteeism than non-smokers for any reason studied including NES. The study indicated a high prevalence of present NES problems (23%) but also that NES as a cause of leave of absence was relatively rare (3%).

Absenteeism↗
PubMed1989

The correlation between work environment and the occurrence of cervicobrachial symptoms.

The correlation between symptoms from the neck and upper extremities and some individual and work-related factors was analyzed in 2814 industrial workers. Physical stress by type of job was the factor most strongly correlated with ongoing cervicobrachial symptoms. Symptoms from the neck and upper extremities were twice as common in workers who used vibrating hand tools. Mental stress at the onset of the symptoms was associated with an increased prevalence of trapezius myalgia and with lateral humeral epicondylitis and "radial tunnel syndrome" in the dominant arm. Women had about double the rate of cervicobrachial symptoms as did men. Short stature increased the rate of symptoms from the neck, shoulders, and hands as did overweight. Playing of racquet sports decreased the risk of symptoms from the neck and hands.

Analysis of Variance↗