PubMed Health⌕ Search

Biomedical subjects

H Aasved

Publications and source records attributed to H Aasved.

At least 19 recordsLinked to original sources
PubMed1995

Retrobulbar anesthesia with and without adrenaline in extracapsular cataract surgery. A prospective, randomized, double-blind study.

Seventy-five patients with senile cataract underwent a planned extracapsular cataract extraction. They were randomly divided into two groups, receiving retrobulbar anesthesia (4 ml lidocaine 2% and 250 IU hyaluronidase) with or without adrenaline. Patients in the adrenaline group had the lowest mean intraocular pressure after the retrobulbar injection (p < 0.02) and they required a shorter time of digital bulbar massage to reduce tension before surgery (p < 0.01). They also appeared to have a deeper anterior chamber during the first part of surgery, although the difference was not statistically significant. The duration of postoperative analgesia was significantly prolonged in patients receiving adrenaline. Different mechanisms explaining the effects of adrenaline in retrobulbar anesthesia are discussed.

Adult↗
PubMed1995

Refractive state and correction of refractive errors among mentally retarded adults in a central institution.

In a population of 212 mentally retarded, retinoscopy could be performed in 342 eyes in 182 patients. Of these, 334 eyes were phakic. Hypermetropia of +5 or more was encountered in 20 eyes (6.0%), while 26 (7.8%) had a myopia of -5 or more. The most striking finding was a high number of severe astigmatism, cylindrical power of -3.25 or more being present in 29 eyes (8.7%). Glasses were initially prescribed to 88 patients. Six months after the prescription, 59.1% used their glasses regularly. Aspects of glass prescription to mentally retarded are discussed in the paper.

Adolescent↗
PubMed1993

Retrobulbar anesthesia with and without hyaluronidase in extracapsular cataract surgery. A prospective, randomized, double-blind study.

Eighty patients with senile cataract were subjected to a planned extracapsular cataract extraction (ECCE) with implantation of a posterior chamber intraocular lens. Retrobulbar anesthesia was administered by injection of 4 mg lidocaine 2% with adrenalin. In 40 patients 150 I.U. hyaluronidase (Kinetin) was added to the anesthesia. The hyaluronidase group had a significantly lower frequency of iris prolapse, and deeper anterior chamber, both before and after expression of the lens nucleus. Possible mechanisms explaining the beneficial effect of hyaluronidase in extracapsular cataract surgery are discussed.

Aged↗
PubMed1991

Multiple-dose, dose-response relationship for the topical carbonic anhydrase inhibitor MK-927.

The multiple-dose, dose-response curve of MK-927 was studied in a five-center, double-masked, randomized, placebo-controlled, parallel study of 2%, 1%, and 0.5% MK-927 in 76 patients with bilateral primary open angle glaucoma or ocular hypertension and intraocular pressure greater than 24 mm Hg following washout of ocular hypotensive medications. Patients received doses at 8 AM and 8 PM for 14 days, and parallel 12-hour intraocular pressure curves were performed prestudy and on day 14, with 4-hour curves on days 1 and 4. There was a significant dose-response relationship, with 0.5% MK-927 twice daily being a minimal-effect dose. Both 1% and 2% MK-927 were active through 12 hours postdose, and peak mean percent decrease in pressure at 2 hours postdose was 18.6% and 20.6%, respectively.

Administration, Topical↗
PubMed1990

Twelve-hour IOP control obtained by a single dose of timolol/pilocarpine combination eye drops.

The 12 h IOP control achieved by a single application of a newly developed ophthalmic solution containing 0.5% timolol and 2% resp. 4% pilocarpine was compared with that obtained by 1 dose of timolol 0.5% alone in 33 patients with manifest open angle glaucoma or ocular hypertension. The combined solutions gave a significantly better 12 h IOP control, evidenced by both a reduced mean diurnal IOP and a decreased frequency of larger pressure peaks.

Administration, Topical↗
PubMed1987

Timolol/pilocarpine combination eye drops in open angle glaucoma and in ocular hypertension. A controlled randomized study.

The effect of a newly developed ophthalmic solution containing both 0.5% timolol and 2% resp. 4% pilocarpine was compared with that of timolol 0.5% eye drops alone in 93 patients with manifest simple or capsular glaucoma or ocular hypertension. The medications were administered twice daily. The absolute additive effect of pilocarpine was small, although the combined solutions caused a statistically significantly greater reduction of the intraocular pressure than that achieved by timolol alone. This additional effect appeared to last at least 12 h. The effect of the test solutions containing 2% resp. 4% pilocarpine was very similar. Apart from the well-known effects of the pilocarpine-induced miosis, the combined test medications were generally well tolerated.

Aged↗
PubMed1986

Prognostic factors in the development of manifest open angle glaucoma. A long-term follow-up study of hypertensive and normotensive eyes.

Ninety-three patients, who during a mass screening for glaucoma in 1962-63 attended a thorough ophthalmological examination, were re-examined in 1980-82. At the mass screening 42 patients had IOP greater than or equal to 21 mmHg in at least 1 eye, but none of the 93 patients had glaucomatous optic disc excavations or visual field defects. At the re-examination, 28 patients (30.1%) had developed manifest open angle glaucoma in at least 1 eye. This development was significantly correlated to the height of the IOP, both at the mass screening, during the period of observation and at the follow-up study (P less than 0.05-P less than 0.002). A reduced outflow facility measured at the mass screening was also significantly associated with the later development of manifest glaucomatous damage (P less than 0.05-P less than 0.01). In addition, fibrillopathy (pseudoexfoliation), manifest glaucoma in the 'fellow eye' and a positive family history for glaucoma were found to be important risk factors.

Adult↗
PubMed1979

Timolol maleate in treatment of open angle glaucoma.

The effect of Timolol maleate on the intraocular pressure in open angle glaucoma has been examined in 37 patients, of these simple glaucoma in 26 (48 eyes), capsular glaucoma in 9 (14 eyes) and chronic secondary glaucoma in 2 patients (2 eyes). These cases constituded a group which was relatively difficult to manage. The average pressure reduction caused by Timolol maleate alone was about 23%. In 18 patients the intraocular pressure was adequately controlled on Timolol as the only drug and in 10 on additional drug therapy. Five patients failed on drug treatment, and the remaining four failed on one eye while the fellow eye was well regulated. Tonography indicates that the effect is caused by a reduction of the aqueous humour production. Side effects of locally applied Timolol maleate have not been observed. This drug may be the drug of choice in many instances.

Adult↗
PubMed1979

Prevalence of fibrillopathia epitheliocapsularis (pseudoexfoliation) and capsular glaucoma.

A mass screening of 8,537 persons above the age of 40 years in Bergen revealed fibrillopathia epitheliocapsularis (pseudoexfoliation) in 75 persons (i.e. 0.9%) and an increased prevalence with increasing age. Comparable geriatric groups in Birmingham, Bonn, and Bergen showed a prevalence of fibrillopathy of 4.0, 4.7, and 6.3% respectively. These differences are not statistically significant. The proportion of capsular glaucoma among patients with open angle glaucoma is higher in groups representing more severe cases of glaucoma than in groups of patients with more easily treatable glaucoma.

Adult↗
PubMed1979

Relationship of intraocular pressure and fibrillopathia epitheliocapsularis.

The average intraocular pressure is higher in eyes with than in eyes without fibrillopathia epitheliocapsularis (pseudo-exfoliation). Open angle glaucoma was diagnosed in 22.7% of persons with fibrillopathy, compared to 1.2% in persons without fibrillopathy. The increase in intraocular pressure and the development of glaucoma seem in most cases to accompany or closely follow the development of fibrillopathy.

Adult↗
PubMed1977

Work and disability at the age of 30 years. A sociomedical study of a birth-cohort from Bergen. VIII. Visual impairment; frequency and relation to school background, intellectual ability and encephalopathy.

The study is based on a cohort of 1570 persons consisting of all live births in 1940 of mothers then residing in Bergen. A sample was taken of the cohort after stratification according to type of school attended at the age of 14 years. The sample was supplemented with persons who had either attended Special Schools for the educable mentally retarded or received care from National Services for the mentally retarded. The final sample consisted of 262 persons. Persons in the sample were examined neurologically, and the results of these examinations formed the basis for further ophthalmological examinations. Frequency of visual impairment in the cohort at the age of 30 years, according to relatively strict criterion, is estimated at 4.6% +/- 2.0 %. Frequency was found to increase with a lower level of education (type of school) and decreasing IQ-points. Pathology of the eye was found most frequently among members of the services for the mentally retarded and was associated with encephalopathy.

Adolescent↗