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Biomedical subjects

H Abdine

Publications and source records attributed to H Abdine.

At least 37 records · Page 2Linked to original sources
PubMed1978

pH-induced difference spectrophotometric assay of acetazolamide, hydrochlorothiazide, and furosemide.

On the basis of pH-induced spectral changes for acetazolamide, hydrochlorothiazide, and furosemide, 3 different spectrophotometric methods are described. The methods were successfully applied to the assay of these drugs in different pharmaceutical formulations (tablets and ampoules). The accuracy of the analysis is increased by using the suggested methods as compared with conventional spectrophotometry.

Acetazolamide↗
PubMed1978

The use of Fourier functions to eliminate interferences in spectrophotometric analysis (theory and application).

The basic principle for the use of Fourier functions in spectrophotometric analysis is discussed. Fourier function coefficients are linearly related to concentration and are associated with relative standard deviations of less than 1%. The proper choice of function and range, number of points and the transformation of an absorption curve are discussed. New trigonometric functions are derived to correct for linear irrelevant absorption. The method is illustrated by the determination of progesterone and testosterone propionate in oily solutions without prior chromatography. The results obtained are compared with those obtained using orthogonal polynomials.

Fourier Analysis↗
PubMed1978

Spectrophotometric determination of chloramphenicol-sulphacetamide in eye drops.

A rapid method for the determination of chloramphenicol in chloramphenicol-sulphacetamide drops is discussed. The method depends upon precipitating sulphacetamide as its silver salt by a solution of silver nitrate. Chloramphenicol is determined in the filtrate using the modified Vierordt's method. Sulphacetamide was determined by suitably diluting the drops with 0.01 N H2SO4 and then applying the modified Vierordt's method. The presence of macrogols proved not to interfere with the determination. Mean percentage recoveries +/- s.d. for chloramphenicol and sulphacetamide were found to be 100.8 +/- 0.95 and 100.2 +/- 1.0, respectively.

Chloramphenicol↗
PubMed1977

The spectrophotometric determination of streptomycins.

The spectra produced by the acid treatment and alkaline treatment of streptomycin and dihydrostreptomycin have been investigated to obtain suitable methods for their determination. Mixtures of the two antibiotics have been successfully determined in the UV region. Thus, using the orthogonal function method, dihydrostreptomycin has been determined after acid treatment whereas streptomycin has been determined after alkaline treatment followed by immediate neutralization.

Dihydrostreptomycin Sulfate↗
PubMed1977

Spectrophotometric determination of some preservatives in milk.

Benzoic acid, propyl p-hydroxybenzoate, and sorbic acid in milk have been determined by using the corresponding first derivative curves of absorption spectra of clarified milk samples. The delta A/delta lambda curves were computed and the concentration of each preservative was calculated using 1 point, 2 points, and/or 3 points. In all cases, the percentage error was within 2.4%.

Animals↗
PubMed1977

Interference by acetylated aminoacetic acid in nonaqueous titration of nicotinic acid.

A nonaqueous titration procedure is described for determining aminoacetic acid and nicotinic acid in mixtures and elixirs. The effect of acetylated aminoacetic acid on the potentiometric titration of nicotinic acid is discussed. Above a 2:1 ration of aminoacetic acid to nicotinic acid, the former interferes with titration. The titration curve of nicotinic acid becomes progressively flatter with increasing amounts of the acetylated compound. Above this ratio, nicotinic acid had to be separated from the mixture by dissolving in ethanol for a successful titration.

Drug Combinations↗
PubMed1976

Nonaqueous titration of sulfates of quinine and quinidine using barium acetate.

A nonaqueous titrimetric method is proposed for determining the diastereomeric sulfates of quinine and quinidine. The sulfuric acid content of the alkaloid salts is precipitated, in the form of barium sulfate, with acetous barium acetate solution before the liberated alkaloid is titrated; the necessary calculations are provided. A favorable characteristic of the proposed procedure is the accuracy, speed, and ease of performance. The mean percent recoveries (p = 0.05) obtained with the proposed method for the sulfates of quinine and quinidine were 98.84 +/- 1.00 and 99.74 +/- 1.27, respectively, compared with 100.73 +/- 1.44 and 100.82 +/- 1.16, respectively, when the BP 1968 procedure was applied.

Acetates↗
PubMed1975

Chemistry of nonaqueous titration of chlopromazine.

The chemistry of the red color formed during perchloric acid titration of chlorpromazine hydrochloride in acetic acid in the presence of mercuric acetate is discussed. Addition of ascorbic acid prevents the color formation and allows titration using a crystal violet end-point. Ascorbic acid addition also sharpens the potentiometric end-point. Ascrobic acid and its oxidation product, dehydroascorbic acid, being neutral to perchloric acid, do not interfere with the titration.

Ascorbic Acid↗