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Biomedical subjects

H Abele

Publications and source records attributed to H Abele.

18 recordsLinked to original sources
PubMed2005

[Diagnosis and antenatal treatment of fetal arrhythmias].

Fetal cardiac arrhythmias are detected with increasing frequency. They may range from benign ectopy to life-threatening arrhythmias. Most centers prefer to administer an antiarrhythmic drug therapy via maternal ingestion and only in specific cases via direct fetal intravascular injection. The medical drug treatment of choice at various centers of fetal tachyarrhythmias include digoxin, flecainide, amiodarone, verapamil and a host of combinations, as well as sotalol. Atrioventricular block, especially in the presence of maternal SS-A and SS-B autoantibodies, can be treated with Dexamethason and partly with Salbutamol, within international study protocols.

Anti-Arrhythmia Agents↗
PubMed2005

Effect of magnesium on red blood cell deformability in pregnancy.

OBJECTIVE: Red blood cell (RBC) deformability is an important factor in determining movement of red blood cells through the microcirculation. In preeclampsia and some cases of intrauterine growth restriction (IUGR), RBC deformability and microcirculation are reduced. Magnesium is administered to reduce the risk of seizures. The aim of this study was first to detect the effect of intravenous magnesium application (2 g/h) on the deformability of RBCs in pregnancies with normal RBC deformability, receiving magnesium as tocolytic agent. The second aim was to examine the effect of calcium-antagonists (magnesium, nifedipin) on the deformability of RBC of preeclamptic patients in vitro. METHODS: Part 1: magnesium (2 g/h), fenoterol (270 microg/h)+verapamil (0.2 mg/h) or placebo (NaCl 0.9%) was administered intravenously to pregnant women with premature contractions to test the tocolytic effect. RBC-deformability was measured by laser diffractoscopy in all three groups. Blood samples were taken before, after 1 h and after 24 h of administration. Magnesium-plasma-levels were measured. Part 2: Blood samples from patients with preeclampsia were incubated in vitro with magnesium (2 mmol), nifedipine (0.25 mg/ml), or placebo (NaCl 0.9%). RBC deformability was measured before and 15 min, 1 h, 2 h, 6 h, and 10 h after start of the incubation. RESULTS: Part 1: The initial RBC-deformability was the same in all groups (E=0.232+/-0.017 in NaCl, 0.232+/-0.023 in fenoterol+verapamil, 0.232+/-0.019 in magnesium). After 1 h of administration, RBC-deformability was significantly greater with magnesium (0.254+/-0.020) and Fenoterol+Verapamil (0.238+/-0.02) compared to placebo (0.231+/-0.015). After 24 h the effect on RBC deformability in the fenoterol+verapamil-group was gone (0.234+/-0.021 compared to 0.234+/-0.016 in placebo), while in the IV-magnesium-group RBC-deformability remained increased (E=0.241+/-0.019). Statistical analysis of the influence of magnesium-plasma-levels showed the maximum effect at concentrations of 1.95-2.15 mmol/l. Part 2: RBC-deformability in preeclampsia was reduced as predicted by previous studies (0.120+0.0086 versus 0.232 in normal pregnancy). In vitro incubation with magnesium enhanced RBC-deformability in preeclampsia. Even after 15 min, a statistically significant effect was seen (0.127+/-0.0091 versus 0.121+/-0.0091 in placebo). Maximum effect was reached after 6 h of incubation (0.159+/-0.0093 versus 0.133+/-0.0091). Incubation with Nifedipine also enhanced RBC deformability [0.127+/-0.0091 after 15 min, 0.149+/-0.010 after 6 h (maximum effect)], but the effect was less pronounced than with magnesium. CONCLUSION: Intravenous magnesium therapy over a 24-hour period increases RBC-deformability even in pregnancies with normal RBC-deformability. In vitro measurements show an increase of RBC-deformability in preeclampsia in response to magnesium, which could offer additional therapeutic benefit for the treatment of reduced blood flow seen in most cases of preeclampsia.

Adult↗
PubMed2002

Is the unitarity of the quark-mixing CKM matrix violated in neutron beta-decay?

We report on a new measurement of neutron beta-decay asymmetry. From the result A(0) = -0.1189(7), we derive the ratio of the axial vector to the vector coupling constant lambda = g(A)/g(V) = -1.2739(19). When included in the world average for the neutron lifetime tau = 885.7(7) s, this gives the first element of the Cabibbo-Kobayashi-Maskawa (CKM) matrix V(ud). With this value and the Particle Data Group values for V(us) and V(ub), we find a deviation from the unitarity condition for the first row of the CKM matrix of Delta = 0.0083(28), which is 3.0 times the stated error.

Journal Article↗
PubMed2000

Neutron polarization induced by radio frequency radiation

We have measured that an unpolarized ultracold neutron beam gets polarized through its interaction with a resonant radio frequency field. Both spin components pass through the field and end up in one single spin state. We present a simple description for this surprising effect together with first experimental results.

Journal Article↗
PubMed1999

[New paths for Internet generated learning in anatomy].

For the purposes of a functioning information and knowledge based medicine the conditions for the medical education are crucial. Although multimedia based courses and tutorials via the Internet seem to serve best for a more effective teaching and new didactics, respective anatomical offers in Germany are scarce and thus practice and experience are limited. Only simple digital equivalents of conventional contents and methods can be found, whereas the potencies of the new media are not realized in didactic concepts. Substantial advantages of web based tutorial systems are an intensive use of the feedback possibilities, the opportunity for continuous updating of the contents, the favourable distribution, and faster utilization of improved techniques. This paper introduces the adaptation of different techniques and the development of concepts and notions of modern Internet based teaching by the way of three different events in anatomical education for medical students and doctors. HistoNet 2000 was developed as an interface of lectures, seminars and practical courses in microscopy. The online transmission of a microscopical course as an interactive practical teleteaching was performed by the way of asymmetric data transfer via the ADSL-technology. Multicasting was used as well and has also been applied for the third project. In this multimedial online teaching different specialties were joined together for interdisciplinary courses via the Internet. These new technologies lead to enhanced efficiency in teaching and enlarge the educational offer. Specific Internet adapted teaching and learning projects have to be developed.

Anatomy↗
PubMedDate not supplied

Morphological investigations of connective tissue structures in the region of the nervus occipitalis major.

The connective tissue lamellae surrounding the n. occipitalis major are arranged in such a way that they form at least two compartments. An outer epineurial, and an inner endoneurial one. The outer compartment is a shifting and sliding layer, the inner one is probably filled with fluid which means that it is relatively incompressible. This fluid could be drawn off and supplied through the widely branched arterial and venous reticulum, the vasa nervorum. Measurements of the connective tissue space area (perineurium, subperineurial space, endoneurium with axon and glia) on the n. occipitalis major showed a high correlation between measured values. In addition, lammellar corpuscles of the Paccini type are regularly found in both compartments. These receptors measure the local pressure and shearing forces. The design of the suspension network along with the course of the muscles in the area of the regio occipitalis, the interdependence of the connective tissue compartments, the diffusion barrier of the perineurium, the mighty vasa nervorum and the occurrence of lamellar corpuscles, all point to a probable connection with the symptom complex of occipital neuralgia.

Connective Tissue↗