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Biomedical subjects

H Abramson

Publications and source records attributed to H Abramson.

9 recordsLinked to original sources
PubMed2005

[A minimally invasive technique to repair pectus carinatum. Preliminary report].

The present report deals with a new technique for the correction of pectus carinatum. Although less frequent than pectus excavatum, this deformity leads to numerous consultations, as it is difficult to conceal and affects the personality and behavior of many young patients. We report the case of a 13-year-old boy with asymmetrical pectus carinatum. The chest wall was compressible, so the protrusion was corrected by means of intrathoracic compression. In this technique, the sternochondral region is compressed by implanting a metal bar in the presternal region and securing it bilaterally to the posterolateral portion of the costal arches. The strut remains implanted until remolding of the chest contour is achieved. In this case, the strut was removed after 1 year and the new chest contour has been maintained unchanged more than 8 months following surgery. In conclusion, this minimally invasive technique for the treatment of pectus carinatum by means of intrathoracic compression appears to be a valid alternative to more invasive techniques and should be considered in appropriate cases.

Adolescent↗
PubMed1995

Postictal psychosis: a case control series of 20 patients and 150 controls.

We compared clinical data, EEG, and video-EEG studies in a consecutive series of 20 patients with postictal psychosis (PP) to 150 consecutive epilepsy patients with complex partial (CPS) or generalized tonic-clonic (GTCS) seizures but without PP. There was a lucid interval between last seizure and onset of psychosis ranging from 2.3 to 72 h (mean, 25 h). Duration of PP ranged from 16 to 432 h (mean, 83 h). Age, sex, epilepsy type (partial vs. generalized), and history of febrile seizures were similar in the PP and control groups. Patients with PP had more frequent GTCS during monitoring than controls (2.8 vs. 1.3; P < 0.001). Patients with PP were more likely to have a history of encephalitis (P < 0.0001) and psychiatric hospitalization (P < 0.002). More patients with PP had bilateral interictal epileptiform discharges during monitoring than controls (P < 0.0002). Postictal psychosis most often develops in patients with bilateral dysfunction following a cluster of GTCS.

Adult↗
PubMed1994

Effectiveness of psychological and pharmacological treatments for nocturnal enuresis.

This review provides a quantitative integration of research on the effectiveness of psychological and pharmacological treatments for nocturnal enuresis. With the use of experiments that compared treatments with either no treatment or another form of treatment, this article assesses (a) the overall effectiveness of psychological and pharmacological treatments, (b) the relative effectiveness of specific types of treatments, and (c) moderators of treatment effectiveness including investigator allegiance. Findings from the review confirm that enuretic children benefit substantially from treatment. However, more children improve from psychological than from pharmacological interventions. Moreover, psychological treatments involving a urine alarm are most likely to yield benefits that are maintained once treatment has ended.

Antidepressive Agents, Tricyclic↗
PubMedDate not supplied

Irreversible inhibition of 3H-ouabain binding to Na+ +K+ -ATPase by digoxigenin-3,12-dibromoacetate, an alkylating derivative of digoxigenin.

Digoxigenin-3,12-dibromoacetate (DDB), an alkylating derivation of digoxigenin, was synthesized and tested as a cardiotonic steroid (CS) site directed affinity label for Na+ +K+ -ATPase (ATP phosphohydrolase EC 3.6.1.3). DDB inhibited rat brain Na+ +K+ -ATPase with an I50 of 5 times 10(-6)M and readily displaced specifically bound 3H-ouabain from its binding sites on Na+ +K+ -ATPase. If the enzyme was exposed to DDB prior to the addition of 3H-ouabain its ability to bind 3H-ouabain was decreased, consistent with the concept that DDB interacted irreversibly with the cardiotonic steroid binding sites of Na+ +K+ -ATPase. However, DDB proved to be an even more effective inhibitor of 3H-ouabain binding under conditions where it was unlikely that it could interact with the CS binding sites of this enzyme, suggesting that DDB inhibited 3H-ouabain binding by non-cardiotonic site directed actions. Similarly, the presence of excess strophanthidin did not protect this enzyme against irreversible inhibition by DDB. The data suggest that the presence of a bromoacetate group at the 12 position on cardiotonic steroids does not confer CS binding site directed alkylating properties on these drugs.

Adenosine Triphosphatases↗